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KIR3DS1 and HLA-B
Number of citations of the paper that reports this interaction (PMID
12134147
)
260
Data Source:
HPRD
(in vivo, in vitro)
KIR3DS1
HLA-B
Gene Name
killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1
major histocompatibility complex, class I, B
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Golgi Membrane
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
ER To Golgi Transport Vesicle Membrane
Membrane
Integral Component Of Membrane
Phagocytic Vesicle Membrane
Early Endosome Membrane
MHC Class I Protein Complex
Extracellular Vesicular Exosome
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Molecular Function
MHC Class I Receptor Activity
Receptor Binding
Peptide Antigen Binding
TAP Binding
Chaperone Binding
Biological Process
Immune Response
Signal Transduction
Natural Killer Cell Activation
Innate Immune Response
Positive Regulation Of T Cell Mediated Cytotoxicity
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent
Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent
Regulation Of T Cell Anergy
Defense Response
Immune Response
Viral Process
Detection Of Bacterium
Cytokine-mediated Signaling Pathway
Regulation Of Interleukin-12 Production
Regulation Of Interleukin-6 Production
Protection From Natural Killer Cell Mediated Cytotoxicity
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Innate Immune Response
Regulation Of Immune Response
Interferon-gamma-mediated Signaling Pathway
Type I Interferon Signaling Pathway
Regulation Of Dendritic Cell Differentiation
Pathways
DAP12 interactions
Innate Immune System
Interferon gamma signaling
Interferon Signaling
Endosomal/Vacuolar pathway
Cytokine Signaling in Immune system
Interferon alpha/beta signaling
Class I MHC mediated antigen processing & presentation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen processing-Cross presentation
ER-Phagosome pathway
Adaptive Immune System
Interferon gamma signaling
Interferon Signaling
Endosomal/Vacuolar pathway
Cytokine Signaling in Immune system
Interferon alpha/beta signaling
Class I MHC mediated antigen processing & presentation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen processing-Cross presentation
ER-Phagosome pathway
Adaptive Immune System
Drugs
Diseases
GWAS
Ankylosing spondylitis (
21743469
)
Beta-2 microglubulin plasma levels (
23417110
)
CD4:CD8 lymphocyte ratio (
20045101
)
Cervical cancer (
23482656
)
Drug-induced liver injury (flucloxacillin) (
19483685
)
Epstein-Barr virus immune response (EBNA-1) (
23326239
)
Graves' disease (
21841780
)
Height (
19343178
23563607
)
HIV-1 control (
20205591
21051598
20041166
)
Hypothyroidism (
22493691
)
Multiple sclerosis (
22190364
19525953
)
Nasopharyngeal carcinoma (
20512145
)
Platelet counts (
22139419
)
Visceral adipose tissue adjusted for BMI (
22589738
)
Vitiligo (
20526339
)
White blood cell count (
21738480
)
Protein-Protein Interactions
2 interactors:
HLA-B
TYROBP
16 interactors:
ARHGEF4
ATF7IP
B2M
CD8A
CSF1
KIR3DL1
KIR3DS1
KLRD1
LILRB1
LILRB2
MAGEA1
SRC
STAT1
TRA
TRB
TRIB3
Entrez ID
3813
3106
HPRD ID
10034
00828
Ensembl ID
ENSG00000234745
Uniprot IDs
O43469
Q14943
Q4KN23
Q99565
E5FQ95
P01889
P30466
S6AU73
PDB IDs
3VCL
4JQV
Enriched GO Terms of Interacting Partners
?
Protection From Natural Killer Cell Mediated Cytotoxicity
Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Regulation Of Osteoclast Development
Regulation Of Dendritic Cell Differentiation
Neutrophil Activation Involved In Immune Response
Regulation Of T Cell Anergy
Macrophage Activation Involved In Immune Response
Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I
Innate Immune Response
Antigen Processing And Presentation Of Endogenous Antigen
Regulation Of Immune Response
Detection Of Bacterium
Neutrophil Activation
Regulation Of Natural Killer Cell Mediated Cytotoxicity
Regulation Of Natural Killer Cell Mediated Immunity
Detection Of Biotic Stimulus
Macrophage Activation
Immune Response
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent
Regulation Of Immune System Process
Negative Regulation Of Innate Immune Response
Defense Response
Cellular Defense Response
Regulation Of Cell Differentiation
Positive Regulation Of T Cell Mediated Cytotoxicity
Regulation Of T Cell Mediated Cytotoxicity
Regulation Of Interleukin-12 Production
Regulation Of Osteoclast Differentiation
Response To External Stimulus
Positive Regulation Of Leukocyte Mediated Cytotoxicity
Positive Regulation Of T Cell Mediated Immunity
Positive Regulation Of Cell Killing
Regulation Of Leukocyte Mediated Cytotoxicity
Type I Interferon Signaling Pathway
Cellular Response To Type I Interferon
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Response To Type I Interferon
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Immune System Process
Interferon-gamma-mediated Signaling Pathway
Regulation Of Interleukin-6 Production
Regulation Of Myeloid Leukocyte Differentiation
Cellular Response To Interferon-gamma
Positive Regulation Of Adaptive Immune Response
Integrin-mediated Signaling Pathway
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Negative Regulation Of Immune Response
Response To Interferon-gamma
Leukocyte Activation Involved In Immune Response
Immune Response
Regulation Of Immune Response
Regulation Of Immune System Process
Defense Response
Immune System Process
Innate Immune Response
Leukocyte Differentiation
Response To Molecule Of Bacterial Origin
Cell Activation
Cellular Response To Lipopolysaccharide
Response To Other Organism
Fc Receptor Mediated Inhibitory Signaling Pathway
Cellular Response To Molecule Of Bacterial Origin
Response To Biotic Stimulus
Response To Stress
Immune Response-inhibiting Cell Surface Receptor Signaling Pathway
Response To Bacterium
Immune Response-inhibiting Signal Transduction
Leukocyte Activation
Single Organismal Cell-cell Adhesion
Regulation Of Dendritic Cell Differentiation
Signal Transduction
Cell Surface Receptor Signaling Pathway
Response To Virus
Hemopoiesis
Signaling
Response To Lipopolysaccharide
Cell Communication
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Immune System Development
Cellular Response To Organic Substance
Positive Regulation Of Cell Adhesion
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Negative Regulation Of Biosynthetic Process
Regulation Of Cellular Process
Lymphocyte Activation
Cellular Response To Lipid
Defense Response To Virus
Enzyme Linked Receptor Protein Signaling Pathway
Cellular Response To Stimulus
Positive Regulation Of Immune System Process
Response To Stimulus
Immune Response-regulating Signaling Pathway
Tissue Homeostasis
Negative Regulation Of Cell Adhesion
Viral Process
Positive Regulation Of T Cell Activation
Cellular Response To Insulin Stimulus
Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Homotypic Cell-cell Adhesion
Tagcloud
?
asian
caucasians
clustered
han
haplotype
implied
joining
killer
kir2dl2
kir2dl3
kir2dl5
kirs
multidimensional
neighbour
outnumbered
plot
province
southern
ssp
tree
yunnan
Tagcloud (Difference)
?
asian
caucasians
clustered
han
haplotype
implied
joining
killer
kir2dl2
kir2dl3
kir2dl5
kirs
multidimensional
neighbour
outnumbered
plot
province
southern
ssp
tree
yunnan
Tagcloud (Intersection)
?