ARF5 and ARFIP2

Number of citations of the paper that reports this interaction (PubMedID 9038142)
0

Data Source:
HPRD (two hybrid, in vitro)

		ARF5	ARFIP2
Description		ARF GTPase 5	ARF interacting protein 2
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome	Ruffle Nucleolus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Cortex Membrane Trans-Golgi Network Membrane
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding	Protein Binding GTP Binding Phospholipid Binding Protein Domain Specific Binding GTP-dependent Protein Binding Small GTPase Binding Identical Protein Binding Cadherin Binding Phosphatidylinositol-4-phosphate Binding Membrane Curvature Sensor Activity
	Biological Process	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Vesicle-mediated Transport	Mitophagy Intracellular Protein Transport Autophagy Small GTPase-mediated Signal Transduction Intracellular Protein Localization Lamellipodium Assembly Actin Cytoskeleton Organization Ruffle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Protein Localization To Phagophore Assembly Site
Pathways		COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Type 2 diabetes ( 23532257)	Malaria ( 31844061)
Interacting Genes		17 interacting genes: ACY3 AP1B1 AP3B1 ARFIP1 ARFIP2 ASAP2 DANCR DENND1A DENND1B DTX3 ERBB2 GGA1 GORAB IKBKG PIP5K1A RAB11FIP3 SNCA	61 interacting genes: AGTRAP AKT1 APP ARF1 ARF3 ARF5 ARF6 ARL1 BLOC1S2 C19orf25 CDKN2A CDR1 CEP63 CMTM5 CYTH3 DGAT2L6 DMAP1 DTNBP1 FADS6 FSD2 GOLGA2 GSG1 HAUS1 HGS ING5 ITGB3BP ITSN1 KRT15 KRT16 LNX1 LY6D MAL2 MIEF1 MIEF2 NDRG4 NFE2L2 NRDE2 NUP62 PBX3 PKNOX2 PLP2 PPIF RAC1 RAC2 RAC3 REEP5 REL RND1 SCAMP1 SCAMP5 SDCBP SH3GLB1 SMG9 SNX1 SOCS2 STAT3 SYP TMEM255B TRIM54 TTPA USHBP1
Entrez ID		381	23647
HPRD ID		00055	07209
Ensembl ID		ENSG00000004059	ENSG00000132254
Uniprot IDs		A4D0Z3 P84085	A0A087X1E4 B4DUZ3 B4DXH2 P53365
PDB IDs		2B6H	1I49 1I4D 1I4L 1I4T 4DCN
Enriched GO Terms of Interacting Partners?		Cellular Localization Establishment Of Localization In Cell Localization Within Membrane Trans-Golgi Network Membrane Intracellular Protein Localization Golgi Apparatus Clathrin-coated Vesicle Membrane Protein Transport Vesicle-mediated Transport To The Plasma Membrane Vesicle-mediated Transport Intracellular Transport Establishment Of Protein Localization Cytosol Clathrin Adaptor Complex Endocytic Recycling Protein Localization To Cell Periphery Protein Domain Specific Binding Melanosome Assembly Endosomal Transport Establishment Of Vesicle Localization GTP-dependent Protein Binding Small GTPase Binding Intracellular Protein Transport Platelet Dense Granule Organization Protein Localization To Membrane Vesicle Localization Phospholipid Binding Ruffle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Early Endosome Phosphatidylinositol Phosphate Binding Membrane Coat Phosphatidylinositol-4-phosphate Binding Protein Localization To Cell Surface Regulation Of Actin Nucleation Synaptic Vesicle Transport Golgi To Plasma Membrane Protein Transport Melanosome Organization Pigment Granule Organization Cytoplasmic Vesicle Membrane Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Saccharopine Dehydrogenase (NADP+, L-lysine-forming) Activity Saccharopine Dehydrogenase Activity Saccharopine Dehydrogenase (NAD+, L-lysine-forming) Activity Saccharopine Dehydrogenase (NAD+, L-glutamate-forming) Activity Negative Regulation Of Retrograde Transport, Endosome To Golgi	Regulation Of Vesicle-mediated Transport Regulation Of Cellular Component Organization Vesicle-mediated Transport Regulation Of Transport Regulation Of Endocytosis GTPase Activity Cellular Localization Protein Binding Protein Transport Regulation Of Receptor-mediated Endocytosis GTP Binding Positive Regulation Of Transport Positive Regulation Of Cellular Component Organization Establishment Of Protein Localization Organelle Organization Regulation Of Postsynapse Organization Cerebral Cortex GABAergic Interneuron Development Intracellular Transport Regulation Of Organelle Organization Regulation Of Cellular Localization Membrane Organization Positive Regulation Of Establishment Of Protein Localization Intracellular Protein Transport Cortical Cytoskeleton Organization Regulation Of Hydrogen Peroxide Metabolic Process NADPH Oxidase Complex Intracellular Protein Localization PTB Domain Binding Regulation Of Dendritic Spine Development Respiratory Burst Lamellipodium Golgi Vesicle Transport Establishment Of Localization In Cell Positive Regulation Of Secretion By Cell Regulation Of Synapse Organization Negative Regulation Of Endocytosis Regulation Of Establishment Of Protein Localization Regulation Of Cytoskeleton Organization Synaptic Vesicle Membrane Erythrocyte Enucleation Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Secretion Regulation Of Receptor Internalization Postsynapse Cytoskeleton Organization Negative Regulation Of Receptor-mediated Endocytosis Endocytosis Protein Kinase Binding Intracellular Signaling Cassette Positive Regulation Of Mitotic Cytokinetic Process
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