ARF5 and PIP5K1A

Number of citations of the paper that reports this interaction (PMID 10589680)
180

Data Source:
HPRD (in vitro)

		ARF5	PIP5K1A
Gene Name		ADP-ribosylation factor 5	phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Plasma Membrane Focal Adhesion Nuclear Speck Lamellipodium Ruffle Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding	Protein Binding ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity Kinase Binding
	Biological Process	Small GTPase Mediated Signal Transduction Metabolic Process Protein Transport Vesicle-mediated Transport	Phospholipid Metabolic Process Glycerophospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phagocytosis Signal Transduction Phospholipid Biosynthetic Process Fibroblast Migration Cell Migration Keratinocyte Differentiation Actin Cytoskeleton Reorganization Activation Of Rac GTPase Activity Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation Focal Adhesion Assembly Cell Chemotaxis Protein Targeting To Plasma Membrane Ruffle Assembly
Pathways			Synthesis of PIPs at the plasma membrane Metabolism of lipids and lipoproteins Phospholipid metabolism PI Metabolism
Drugs
Diseases
GWAS		Type 2 diabetes ( 23532257)
Protein-Protein Interactions		9 interactors: AP1B1 AP3B1 ARFIP1 ARFIP2 ASAP2 GGA1 IKBKG PIP5K1A RAB11FIP3	11 interactors: APP ARF1 ARF5 ARF6 BTK CADPS CASP3 PIP5KL1 PLD1 PLD2 TEC
Entrez ID		381	8394
HPRD ID		00055	04470
Ensembl ID		ENSG00000004059	ENSG00000143398
Uniprot IDs		A4D0Z3 P84085	A6PW57 Q99755
PDB IDs		2B6H
Enriched GO Terms of Interacting Partners?		Establishment Of Localization In Cell Cellular Localization Intracellular Transport Intracellular Protein Transport Cellular Protein Localization Protein Transport Vesicle-mediated Transport Ruffle Organization Establishment Of Protein Localization Protein Localization Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Positive Regulation Of NK T Cell Differentiation Establishment Of Vesicle Localization Vesicle Localization	Intracellular Signal Transduction Vesicle-mediated Transport Small GTPase Mediated Signal Transduction Signaling Cell Communication Glycerophospholipid Metabolic Process Phosphatidylglycerol Biosynthetic Process Glycerolipid Metabolic Process Phospholipid Metabolic Process Organelle Localization Response To Oxidative Stress Cellular Copper Ion Homeostasis Signal Transduction Copper Ion Homeostasis Phosphatidic Acid Biosynthetic Process Phosphatidic Acid Metabolic Process Phosphate-containing Compound Metabolic Process Glycerophospholipid Biosynthetic Process Establishment Of Vesicle Localization Vesicle Localization Peptidyl-tyrosine Autophosphorylation B Cell Receptor Signaling Pathway Phospholipid Biosynthetic Process Lipid Metabolic Process Regulation Of Immune System Process Immune System Process Defense Response Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Neuron Apoptotic Process Cellular Localization Innate Immune Response Establishment Of Organelle Localization Neuron Death Exocytosis Regulation Of B Cell Cytokine Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Neuromuscular Process Controlling Balance Cellular Lipid Metabolic Process Apoptotic Process Programmed Cell Death Organophosphate Metabolic Process Synaptic Growth At Neuromuscular Junction Cellular Response To Molecule Of Fungal Origin Cell Death Death Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Synaptic Vesicle Transport
Tagcloud ?		arabidopsis arfs aspect aux auxin back broadly coincide correct entire feed iaa indispensable influences modules monopteros mp nearly onto redundantly repressors retardation steroid subclades subsets thaliana transduction virtually	1q address akt3 amplified cascades copy cosmic encodes encoding enzymes evident extending iiibeta isozyme issue localize mutational neu numerically oncogenes phosphatidylinositol phosphoinositide pi3kc2b pi4kb quartet resource signalling structurally uncommon
Tagcloud (Difference) ?		arabidopsis arfs aspect aux auxin back broadly coincide correct entire feed iaa indispensable influences modules monopteros mp nearly onto redundantly repressors retardation steroid subclades subsets thaliana transduction virtually	1q address akt3 amplified cascades copy cosmic encodes encoding enzymes evident extending iiibeta isozyme issue localize mutational neu numerically oncogenes phosphatidylinositol phosphoinositide pi3kc2b pi4kb quartet resource signalling structurally uncommon
Tagcloud (Intersection) ?