ARF5 and DENND1A

Number of citations of the paper that reports this interaction (PubMedID 33443570)
75

Data Source:
BioGRID (pull down)

		ARF5	DENND1A
Description		ARF GTPase 5	DENN domain containing 1A
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytosol Plasma Membrane Membrane Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Synapse
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding	Guanyl-nucleotide Exchange Factor Activity Lipid Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Phosphate Binding
	Biological Process	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Vesicle-mediated Transport	Endocytosis Protein Transport Endocytic Recycling Regulation Of Rab Protein Signal Transduction
Pathways		COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Type 2 diabetes ( 23532257)	Adventurousness ( 30643258) Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Body mass index ( 26426971) Body mass index in non-asthmatics ( 23517042) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Depression ( 29700475) Feeling nervous ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Macular thickness ( 30535121) Major depressive disorder ( 27479909) Myopia (pathological) ( 23049088) Personality dimensions ( 20691247) Polycystic ovary syndrome ( 21151128 30566500 26416764 26284813) Polycystic ovary syndrome (adjusted for age and BMI) ( 34791234) Polycystic ovary syndrome (adjusted for age) ( 34791234) Rheumatoid arthritis ( 30891314) Self-reported risk-taking behaviour ( 30271922) Suffering from nerves ( 29500382) Tea consumption ( 31046077) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Waist circumference ( 23966867)
Interacting Genes		17 interacting genes: ACY3 AP1B1 AP3B1 ARFIP1 ARFIP2 ASAP2 DANCR DENND1A DENND1B DTX3 ERBB2 GGA1 GORAB IKBKG PIP5K1A RAB11FIP3 SNCA	4 interacting genes: ARF1 ARF4 ARF5 PCM1
Entrez ID		381	57706
HPRD ID		00055	17221
Ensembl ID		ENSG00000004059	ENSG00000119522
Uniprot IDs		A4D0Z3 P84085	A0A0A0MS48 Q8TEH3 Q9HCG4
PDB IDs		2B6H	6EKK
Enriched GO Terms of Interacting Partners?		Cellular Localization Establishment Of Localization In Cell Localization Within Membrane Trans-Golgi Network Membrane Intracellular Protein Localization Golgi Apparatus Clathrin-coated Vesicle Membrane Protein Transport Vesicle-mediated Transport To The Plasma Membrane Vesicle-mediated Transport Intracellular Transport Establishment Of Protein Localization Cytosol Clathrin Adaptor Complex Endocytic Recycling Protein Localization To Cell Periphery Protein Domain Specific Binding Melanosome Assembly Endosomal Transport Establishment Of Vesicle Localization GTP-dependent Protein Binding Small GTPase Binding Intracellular Protein Transport Platelet Dense Granule Organization Protein Localization To Membrane Vesicle Localization Phospholipid Binding Ruffle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Early Endosome Phosphatidylinositol Phosphate Binding Membrane Coat Phosphatidylinositol-4-phosphate Binding Protein Localization To Cell Surface Regulation Of Actin Nucleation Synaptic Vesicle Transport Golgi To Plasma Membrane Protein Transport Melanosome Organization Pigment Granule Organization Cytoplasmic Vesicle Membrane Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Saccharopine Dehydrogenase (NADP+, L-lysine-forming) Activity Saccharopine Dehydrogenase Activity Saccharopine Dehydrogenase (NAD+, L-lysine-forming) Activity Saccharopine Dehydrogenase (NAD+, L-glutamate-forming) Activity Negative Regulation Of Retrograde Transport, Endosome To Golgi	GTPase Activity Cellular Localization GTP Binding Establishment Of Localization In Cell Intracellular Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intracellular Protein Localization Intracellular Protein Transport Mitotic Cleavage Furrow Ingression Cleavage Furrow Ingression Phospholipase D Activator Activity Protein-containing Complex Localization To Centriolar Satellite Plasma Membrane Bounded Cell Projection Organization Protein Transport Cell Projection Organization Interkinetic Nuclear Migration Vesicle-mediated Transport Establishment Of Protein Localization NAD+-protein-arginine ADP-ribosyltransferase Activity Cilium Assembly Golgi Vesicle Transport Intraciliary Transport Involved In Cilium Assembly Golgi Apparatus Cilium Organization Plasma Membrane Bounded Cell Projection Assembly Microtubule Anchoring At Centrosome Cell Projection Assembly Microtubule Anchoring At Microtubule Organizing Center Nucleotide Binding Intracellular Copper Ion Homeostasis Long-term Synaptic Depression Apical Protein Localization Dendritic Spine Development Regulation Of Protein Complex Stability Copper Ion Homeostasis Pericentriolar Material Neuronal Stem Cell Population Maintenance Mitotic Cytokinetic Process Regulation Of Arp2/3 Complex-mediated Actin Nucleation Extracellular Exosome Microtubule Anchoring Protein Localization To Centrosome Nuclear Migration Nucleus Localization Non-motile Cilium Golgi Membrane Dendritic Spine Organization Epidermal Growth Factor Receptor Binding Protein Localization To Organelle Ciliary Transition Zone
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