SNTB1 and ADRA1D

Number of citations of the paper that reports this interaction (PubMedID 18468998)
51

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		SNTB1	ADRA1D
Description		syntrophin beta 1	adrenoceptor alpha 1D
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Dystrophin-associated Glycoprotein Complex Membrane Protein-containing Complex Sarcolemma Synapse Anchoring Junction	Plasma Membrane Membrane
	Molecular Function	Actin Binding Structural Molecule Activity Protein Binding Calmodulin Binding PDZ Domain Binding	G Protein-coupled Receptor Activity Adrenergic Receptor Activity Alpha1-adrenergic Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Muscle Contraction	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Vasoconstriction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Neuron-glial Cell Signaling
Pathways		Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Adrenoceptors G alpha (q) signalling events G alpha (12/13) signalling events
Drugs			Amphetamine Midodrine Ranolazine Cabergoline Ropinirole Dapiprazole Dihydroergotamine Amitriptyline Alfuzosin Alfuzosin Norepinephrine Mirtazapine Phenylephrine Prochlorperazine Prazosin Prazosin Imipramine Chlorpromazine Buspirone Nortriptyline Amoxapine Clonidine Doxazosin Labetalol Nicardipine Verapamil Epinephrine Phentolamine Ergotamine Tizanidine Tamsulosin Paroxetine Methoxamine Fenoldopam Dobutamine Quinidine Phenoxybenzamine Maprotiline Oxymetazoline Ergoloid mesylate Promethazine Carvedilol Carvedilol Doxepin Desipramine Terazosin Escitalopram Pergolide Bromocriptine Quetiapine Mephentermine Methotrimeprazine Dextroamphetamine Dronedarone R450 Epicept NP-1 Sertindole Mianserin Pizotifen Silodosin Ocaperidone Droxidopa Xylometazoline Tetryzoline Perospirone Dosulepin Etoperidone Lorpiprazole Cirazoline Synephrine Arotinolol Moxisylyte Aranidipine Pipamperone Racepinephrine Dihydroergocornine DL-Methylephedrine Indigotindisulfonic acid Tiapride Dihydroergocristine
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Cerebrospinal T-tau levels ( 28247064) Eye morphology ( 29921221) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 33339817 29083408) JT interval (sulfonylurea treatment interaction) ( 27958378) Myopia (pathological) ( 23406873) Myopia (severe) ( 23933737) Periodontitis (CDC/AAP) ( 24024966) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Thalamus volume ( 31530798)	Paneth cell defects in Crohn's disease ( 28352666) Preeclampsia ( 23551011) Sense of smell ( 26632684)
Interacting Genes		15 interacting genes: ABCA1 ACVR2B ADGRB1 ADRA1D DGKZ DMD DTNA ERBB4 KCNJ12 MAPK12 RPS6KA1 SCN4A SCN5A UTRN VANGL2	8 interacting genes: ADRA1A FLNC LNX1 NOS1 SNTA1 SNTB1 SNTB2 SNTG1
Entrez ID		6641	146
HPRD ID		02490	00079
Ensembl ID		ENSG00000172164	ENSG00000171873
Uniprot IDs		Q13884	B0ZBE0 P25100
PDB IDs		7P70 7PC4
Enriched GO Terms of Interacting Partners?		Muscle Contraction Muscle System Process Plasma Membrane Sarcolemma Muscle Organ Development Muscle Structure Development Regulation Of Sodium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Cell Communication Regulation Of Multicellular Organismal Process Lateral Plasma Membrane Regulation Of Sodium Ion Transport Vinculin Binding Striated Muscle Contraction Nitric-oxide Synthase Binding Voltage-gated Sodium Channel Complex Regulation Of Blood Circulation Regulation Of System Process Dystrophin-associated Glycoprotein Complex Regulation Of Striated Muscle Contraction Signal Transduction Cell-cell Signaling System Process Regulation Of Monoatomic Ion Transmembrane Transport Action Potential Regulation Of Skeletal Muscle Contraction Filopodium Membrane Voltage-gated Sodium Channel Activity Kinase Activity Signaling Establishment Of Planar Polarity Monoatomic Ion Channel Complex Synaptic Signaling Membrane Protein Serine/threonine/tyrosine Kinase Activity Phagocytosis, Engulfment Regulation Of Monoatomic Ion Transport Regulation Of Developmental Process Monoatomic Cation Channel Activity Regulation Of Muscle Contraction Sodium Channel Activity Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Developmental Process Regulation Of Biological Quality Regulation Of Heart Contraction Cardiac Muscle Contraction T-tubule ATP Binding Membrane Invagination Sphingolipid Floppase Activity	Dystrophin-associated Glycoprotein Complex Sarcolemma Actin Binding Muscle Contraction Calmodulin Binding Structural Molecule Activity Syntrophin Complex Muscle System Process PDZ Domain Binding Cytoskeleton Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of The Force Of Heart Contraction Regulation Of Heart Contraction Sodium Channel Regulator Activity Regulation Of Membrane Repolarization Regulation Of Sodium Ion Transmembrane Transport Regulation Of Blood Circulation Protein-containing Complex Regulation Of Action Potential Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Sodium Ion Transport Caveola Regulation Of Cardiac Muscle Contraction Anchoring Junction Cytoplasm Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Regulation Of Membrane Potential Phospholipase C-activating Adrenergic Receptor Signaling Pathway Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Striated Muscle Contraction Focal Adhesion Synaptic Signaling By Nitric Oxide Regulation Of Heart Rate Pilomotor Reflex Alpha1-adrenergic Receptor Activity Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Nitric-oxide Synthase Activity Negative Regulation Of Serotonin Uptake Tetrahydrobiopterin Binding Positive Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Peptidyl-cysteine S-nitrosylase Activity Z Disc Regulation Of System Process Transmembrane Transporter Binding Regulation Of Serotonin Uptake Blood Vessel Diameter Maintenance Neuron-glial Cell Signaling Regulation Of Tube Size
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?