SNTB1 and SCN4A

Number of citations: 64 (PubMedID 9412493)
Data Source: HPRD (in vitro)

		SNTB1	SCN4A
Name		syntrophin beta 1	sodium voltage-gated channel alpha subunit 4
Structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Dystrophin-associated Glycoprotein Complex Membrane Protein-containing Complex Sarcolemma Synapse Anchoring Junction	Voltage-gated Sodium Channel Complex Plasma Membrane Membrane Monoatomic Ion Channel Complex
	Molecular Function	Actin Binding Structural Molecule Activity Protein Binding Calmodulin Binding PDZ Domain Binding	Monoatomic Ion Channel Activity Voltage-gated Sodium Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity Protein Binding
	Biological Process	Muscle Contraction	Action Potential Monoatomic Ion Transport Sodium Ion Transport Muscle Contraction Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Skeletal Muscle Contraction By Action Potential
Pathways		Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs		None	Ranolazine Topiramate Lidocaine Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Propofol Cocaine Zonisamide Promethazine Chloroprocaine Flecainide Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Parachlorophenol Dichlorobenzyl alcohol Bioallethrin Fish oil
Diseases		None	Congenital myasthenic syndrome Hyperkalemic periodic paralysis (HyperPP) Hypokalemic periodic paralysis (HypoPP) Paramyotonia congenita (PMC) Potassium-aggravated myotonias (PAMs), including: Myotonia fluctuans; Myotonia permanens; Acetazolamide responsive myotonia
GWAS		Apolipoprotein A1 levels ( 32203549 ) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809 ) Cerebrospinal T-tau levels ( 28247064 ) Eye morphology ( 29921221 ) HDL cholesterol levels ( 32203549 28334899 30698716 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) High density lipoprotein cholesterol levels ( 33339817 29083408 ) JT interval (sulfonylurea treatment interaction) ( 27958378 ) Myopia (pathological) ( 23406873 ) Myopia (severe) ( 23933737 ) Periodontitis (CDC/AAP) ( 24024966 ) Refractive error ( 32231278 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Thalamus volume ( 31530798 )	Height ( 28552196 31562340 ) Hip circumference adjusted for BMI ( 34021172 )
Interacting Genes		15 interacting genes: ABCA1 ACVR2B ADGRB1 ADRA1D DGKZ DMD DTNA ERBB4 KCNJ12 MAPK12 RPS6KA1 SCN4A SCN5A UTRN VANGL2	10 interacting genes: CALM1 DLG1 DLG2 DLG3 ERBIN NHERF1 PATJ SNTA1 SNTB1 SNTB2
Entrez ID		6641	6329
HPRD ID		02490	04912
Ensembl ID		ENSG00000172164	ENSG00000007314
Uniprot IDs		Q13884	P35499
PDB IDs		7P70 7PC4	6AGF 6MBA 6MC9
GO Terms Enriched among Interactors		Muscle Contraction Muscle System Process Plasma Membrane Sarcolemma Muscle Organ Development Muscle Structure Development Regulation Of Sodium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Cell Communication Regulation Of Multicellular Organismal Process Lateral Plasma Membrane Regulation Of Sodium Ion Transport Vinculin Binding Striated Muscle Contraction Nitric-oxide Synthase Binding Voltage-gated Sodium Channel Complex Regulation Of Blood Circulation Regulation Of System Process Dystrophin-associated Glycoprotein Complex Regulation Of Striated Muscle Contraction Signal Transduction Cell-cell Signaling System Process Regulation Of Monoatomic Ion Transmembrane Transport Action Potential Regulation Of Skeletal Muscle Contraction Filopodium Membrane Voltage-gated Sodium Channel Activity Kinase Activity Signaling Establishment Of Planar Polarity Monoatomic Ion Channel Complex Synaptic Signaling Membrane Protein Serine/threonine/tyrosine Kinase Activity Phagocytosis, Engulfment Regulation Of Monoatomic Ion Transport Regulation Of Developmental Process Monoatomic Cation Channel Activity Regulation Of Muscle Contraction Sodium Channel Activity Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Developmental Process Regulation Of Biological Quality Regulation Of Heart Contraction Cardiac Muscle Contraction T-tubule ATP Binding Membrane Invagination Sphingolipid Floppase Activity	Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Neuromuscular Junction Anchoring Junction Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Dystrophin-associated Glycoprotein Complex Ionotropic Glutamate Receptor Binding Plasma Membrane Receptor Localization To Synapse Receptor Clustering Phosphatase Binding Protein Localization To Synapse Basolateral Plasma Membrane Regulation Of Sodium Ion Transport GMP Kinase Activity PDZ Domain Binding Protein Localization To Cell Junction GDP Metabolic Process Protein Localization To Membrane Kinase Binding Postsynaptic Density Membrane Regulation Of Metal Ion Transport Sarcolemma Bicellular Tight Junction Transmembrane Transporter Binding Regulation Of Monoatomic Ion Transport Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Protein Kinase Binding Regulation Of Cardiac Muscle Cell Action Potential GMP Metabolic Process Structural Molecule Activity Regulation Of Biological Quality Adherens Junction Localization Within Membrane Calmodulin Binding Regulation Of Heart Contraction Cell Junction Muscle Contraction Regulation Of System Process Regulation Of Sodium Ion Transmembrane Transport Regulation Of Blood Circulation Sperm Midpiece Muscle System Process Regulation Of Monoatomic Cation Transmembrane Transport Tight Junction Assembly Tight Junction Organization Regulation Of Action Potential