ABLIM1 and HUNK

Number of citations: 83 (PubMedID 35914814)
Data Source: BioGRID (two hybrid)

		ABLIM1	HUNK
Name		actin binding LIM protein 1	hormonally up-regulated Neu-associated kinase
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytoskeleton Postsynaptic Density Actin Cytoskeleton Lamellipodium	Cytoplasm
	Molecular Function	Actin Binding Protein Binding Metal Ion Binding Actin Filament Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Transcription By RNA Polymerase II Cytoskeleton Organization Axon Guidance Visual Perception Animal Organ Morphogenesis Lamellipodium Assembly Positive Regulation Of Transcription By RNA Polymerase II Cilium Assembly	Signal Transduction Intracellular Signal Transduction
Pathways		DCC mediated attractive signaling	None
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325 ) Metabolite levels ( 23823483 ) Obesity-related traits ( 23251661 ) Paclitaxel disposition in epithelial ovarian cancer ( 29367611 ) Taste perception (total score including 6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965 )	Crohn's disease ( 32581322 ) Joint damage progression in ACPA-negative rheumatoid arthritis ( 26077402 ) LDL cholesterol levels in HIV infection ( 33109212 ) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309 ) Type 2 diabetes ( 21490949 ) Vitiligo ( 19890347 )
Interacting Genes		27 interacting genes: ACTB ACTG1 APP BEGAIN CALCOCO2 CARD9 CCDC57 DAPK1 FHL2 GOLGA2 HOOK2 HSF2BP HUNK KCNJ12 KLHL20 KRT15 LDOC1 LRRK2 MFHAS1 PTPRD SREBF2 TRAF2 TSC22D4 TTN USHBP1 VIM YWHAG	92 interacting genes: AARS1 ABLIM1 ACTR8 AGAP3 AIP AKAP8L AKR1C3 ALAD ANXA7 APBA2 APPL2 ARMCX4 ASCL1 ASPA ATP5F1B BIN1 CAMK1 CCAR1 CLU COG2 COPA COPS4 COPS5 CTDSP1 CTR9 CXXC5 DIS3L DLAT DLST DNAJA1 DST EEF1A2 EFNA1 EIF4G1 EPRS1 GEN1 HEATR6 HEY1 IFT81 IFT88 KDM6A KIF3A LIMK1 LNX1 LRSAM1 LURAP1 MAGED1 MBD1 MCHR1 MGAT5B MOAP1 MORF4L2 MTMR10 MYCBP2 N4BP2L2 NAPA NEUROD2 OLR1 PICK1 PITHD1 PPP1R16B PTPRA PTPRD RAB5B RABEP1 SH2B1 SLC6A1 SMARCE1 SMYD2 SNRNP48 SNRNP70 SORBS1 SPARCL1 STMN1 STUB1 TAF1 TOMM6 TRIM68 TTC28 UBE2O USP8 VCPIP1 VPS35L VSNL1 ZBTB44 ZNF197 ZNF292 ZNF343 ZNF655 ZNF662 ZNF76 ZNF793
Entrez ID		3983	30811
HPRD ID		03819	09410
Ensembl ID		ENSG00000099204	ENSG00000142149
Uniprot IDs		A0A9L9PY99 B3KSG3 B4DQA3 B7Z4H1 O14639	P57058
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Identical Protein Binding Response To Muramyl Dipeptide Cytoskeleton Regulation Of Synaptic Vesicle Endocytosis Cytoskeleton Organization Regulation Of Synaptic Vesicle Recycling Regulation Of Transepithelial Transport Cytoplasm Structural Constituent Of Cytoskeleton Response To Type II Interferon Dense Body Axon Morphogenesis Of A Polarized Epithelium Cellular Response To Oxygen-containing Compound Structural Constituent Of Postsynaptic Actin Cytoskeleton Actin Cytoskeleton Regulation Of JNK Cascade Cellular Response To Manganese Ion Cellular Response To Muramyl Dipeptide Response To Cytokine Response To Peptide Cellular Response To Type II Interferon Response To Manganese Ion Protein Homooligomerization Intracellular Signal Transduction Regulation Of Autophagy Postsynaptic Actin Cytoskeleton Organization Golgi-associated Vesicle Phagocytic Vesicle Protein Localization To Cell-cell Junction Calyx Of Held Synapse Regulation Of Protein Localization Positive Regulation Of Gene Expression Protein Tetramerization Regulation Of Amyloid-beta Clearance Regulation Of Calcium-mediated Signaling Cellular Response To Catecholamine Stimulus Response To Catecholamine Syntaxin-1 Binding Focal Adhesion Postsynaptic Cytoskeleton Organization Schaffer Collateral - CA1 Synapse Positive Regulation Of JNK Cascade Cellular Component Assembly Protein Kinase Binding Protein Complex Oligomerization Positive Regulation Of MAPK Cascade Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production	Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Metal Ion Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Protein Catabolic Process Regulation Of Cellular Component Organization Negative Regulation Of Protein Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Fibril Formation Protein Modification By Small Protein Conjugation Regulation Of RNA Biosynthetic Process DeNEDDylase Activity