ABLIM1 and PTPRD

Number of citations of the paper that reports this interaction (PubMedID 22305495)
32

Data Source:
BioGRID (pull down)

		ABLIM1	PTPRD
Description		actin binding LIM protein 1	protein tyrosine phosphatase receptor type D
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytoskeleton Postsynaptic Density Actin Cytoskeleton Lamellipodium	Plasma Membrane Membrane Presynaptic Membrane Extracellular Exosome Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse
	Molecular Function	Actin Binding Protein Binding Metal Ion Binding Actin Filament Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Signaling Receptor Binding Protein Binding Hydrolase Activity Cell Adhesion Molecule Binding
	Biological Process	Transcription By RNA Polymerase II Cytoskeleton Organization Axon Guidance Visual Perception Animal Organ Morphogenesis Lamellipodium Assembly Positive Regulation Of Transcription By RNA Polymerase II Cilium Assembly	Phosphate-containing Compound Metabolic Process Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signal Transduction Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Nervous System Development Neuron Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Dendrite Morphogenesis Regulation Of Immune Response Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synapse Assembly Positive Regulation Of Dendritic Spine Morphogenesis Presynaptic Membrane Assembly Presynapse Assembly Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling Trans-synaptic Signaling By Trans-synaptic Complex Synaptic Membrane Adhesion
Pathways		DCC mediated attractive signaling	Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
Drugs
Diseases
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Taste perception (total score including 6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Airflow obstruction ( 22837378) Anxiety and major depressive disorder ( 24047446) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Bitter alcoholic beverage consumption ( 31046077) Body mass index (change over time) in gastrointestinal cancer or chronic obstructive pulmonary disease ( 28044437) Cardiac Troponin-T levels ( 31014085) Cardiorespiratory fitness (800m run time) ( 32572135) Cerebrospinal P-tau181p levels ( 28247064) Chronotype ( 30696823) DHEAS levels ( 34748635) Diastolic blood pressure ( 30224653) Early age at menarche ( 29773799) Endometrial cancer (endometrioid histology) ( 30093612) Endometriosis or endometrial cancer (pleiotropy) ( 29608257) Epilepsy (remission after treatment) ( 23962720) Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer ( 28429243) Femur bone mineral density x serum urate levels interaction ( 34046847) Gait rhythm ( 26219847) Glycine levels ( 31070104) Gout ( 22179738) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels in HIV infection ( 33109212) Heel bone mineral density ( 30598549) Immune response to measles-mumps-rubella vaccine ( 24811271) Intracranial aneurysm ( 29531279) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Lean body mass ( 28552196) Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Loneliness (multivariate analysis) ( 27629369) Low susceptibility to hepatitis C infection ( 31206233) Menarche (age at onset) ( 29773799 25231870) Metabolite levels ( 23823483) Midgestational circulating levels of PCBs (fetal genetic effect) ( 28235828) Moderate-to-late spontaneous preterm birth ( 31194736) Modic changes ( 30808802) Mood instability ( 29187730) Morning person ( 30696823) Myopia (pathological) ( 23049088) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Non-response to antidepressants and depression ( 27622933) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 24821223) Obsessive-compulsive traits ( 33531474) Opioid use cessation ( 31936517) Palmitic acid (16:0) levels ( 23362303) Parkinson's disease progression (motor) ( 33111402) Partial epilepsies ( 20522523) Pelvic organ prolapse (moderate/severe) ( 26545240) Personality dimensions ( 23903073) Pit-and-Fissure caries ( 24556642) Plasma clusterin levels ( 26545630) Platelet aggregation ( 20526338) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pulse pressure ( 27841878) Pursuit maintenance gain ( 29064472) Resistant hypertension ( 30237584) Resting-state electroencephalogram vigilance ( 29703947) Restless legs syndrome ( 18660810 33239738 29029846 21779176) Short-term memory (digit-span task) ( 30741946) Smoking initiation ( 33082346) spontaneous preterm birth x maternal stress interaction (1df) ( 32726798) Subcutaneous adipose tissue ( 26480920) Systolic blood pressure ( 30224653 27841878) Temperament ( 22832960) Third ventricle volume ( 31530798) Triglyceride levels ( 34074324) Triglyceride levels in HIV infection ( 33109212) Type 2 diabetes ( 21647700 20174558) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) White matter hyperintensities in ischemic stroke ( 26674333)
Interacting Genes		27 interacting genes: ACTB ACTG1 APP BEGAIN CALCOCO2 CARD9 CCDC57 DAPK1 FHL2 GOLGA2 HOOK2 HSF2BP HUNK KCNJ12 KLHL20 KRT15 LDOC1 LRRK2 MFHAS1 PTPRD SREBF2 TRAF2 TSC22D4 TTN USHBP1 VIM YWHAG	42 interacting genes: ABLIM1 AURKA BMX CSNK1D CSNK1E DDX17 DDX54 EPHA8 ERG GPC4 GRIK1 HUNK IL1RAP IRS1 KCNJ6 MARK2 MATK MTNR1A MTNR1B MTSS1 NEK1 NEK2 NEK6 OMG PAK6 PLK1 PPFIA1 PPFIA2 PPFIA3 PTPRA PTPRE PTPRF PTPRS RCAN1 RSPH1 SCEL SLAIN2 SLITRK1 SMTNL2 TBK1 TMEM132D TSSK2
Entrez ID		3983	5789
HPRD ID		03819	03358
Ensembl ID		ENSG00000099204	ENSG00000153707
Uniprot IDs		A0A9L9PY99 B3KSG3 B4DQA3 B7Z4H1 O14639	P23468 Q2HXI4 Q3KPI9 Q59H90
PDB IDs			1X5Z 2DLH 2YD6 2YD7 4RCA 5WY8 5XNP 6X3A
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Response To Muramyl Dipeptide Cytoskeleton Regulation Of Synaptic Vesicle Endocytosis Cytoskeleton Organization Regulation Of Synaptic Vesicle Recycling Regulation Of Transepithelial Transport Cytoplasm Structural Constituent Of Cytoskeleton Response To Type II Interferon Dense Body Axon Morphogenesis Of A Polarized Epithelium Cellular Response To Oxygen-containing Compound Structural Constituent Of Postsynaptic Actin Cytoskeleton Actin Cytoskeleton Regulation Of JNK Cascade Cellular Response To Manganese Ion Cellular Response To Muramyl Dipeptide Response To Cytokine Response To Peptide Cellular Response To Type II Interferon Response To Manganese Ion Protein Homooligomerization Intracellular Signal Transduction Regulation Of Autophagy Postsynaptic Actin Cytoskeleton Organization Golgi-associated Vesicle Phagocytic Vesicle Protein Localization To Cell-cell Junction Calyx Of Held Synapse Regulation Of Protein Localization Positive Regulation Of Gene Expression Protein Tetramerization Regulation Of Amyloid-beta Clearance Regulation Of Calcium-mediated Signaling Cellular Response To Catecholamine Stimulus Response To Catecholamine Syntaxin-1 Binding Focal Adhesion Postsynaptic Cytoskeleton Organization Schaffer Collateral - CA1 Synapse Positive Regulation Of JNK Cascade Cellular Component Assembly Protein Kinase Binding Protein Complex Oligomerization Positive Regulation Of MAPK Cascade Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production	Protein Kinase Activity Protein Phosphorylation Phosphorylation Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Synaptic Membrane Adhesion ATP Binding Phosphate-containing Compound Metabolic Process Nucleotide Binding Protein Autophosphorylation Protein Modification Process Microtubule Cytoskeleton Organization Signal Transduction Cytoskeleton Organization Centrosome Separation Peptidyl-serine Phosphorylation Cell Adhesion Transmembrane Receptor Protein Tyrosine Phosphatase Activity Transferase Activity Protein Localization To Centrosome Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Melatonin Receptor Activity Spindle Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Projection Organization Spindle Assembly Mitotic Spindle Organization Protein Tyrosine Phosphatase Activity Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Microtubule-based Process Presynaptic Active Zone Spindle Microtubule Cytoskeleton Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Proteasomal Protein Catabolic Process Cell Surface Receptor Signaling Pathway Protein Localization To Cytoskeleton Plasma Membrane Bounded Cell Projection Organization Protein Tyrosine Kinase Activity Microtubule Cytoskeleton Organization Involved In Mitosis Mitotic Nuclear Membrane Disassembly Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Phosphoprotein Phosphatase Activity Synapse Organization Postsynaptic Density Glutamatergic Synapse
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