CBR3 and IL10RB

Data Source: HiPPIP (Novel)

		CBR3	IL10RB
Name		carbonyl reductase 3	interleukin 10 receptor subunit beta
Structure
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Cytoplasm Cytosol	Plasma Membrane Membrane Interleukin-28 Receptor Complex
	Molecular Function	3-beta-hydroxysteroid 3-dehydrogenase (NADP+) Activity Carbonyl Reductase (NADPH) Activity Protein Binding NADPH Dehydrogenase (quinone) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor NADPH Binding	Interleukin-10 Receptor Activity Protein Binding Coreceptor Activity Signaling Receptor Activity
	Biological Process	Xenobiotic Metabolic Process Phylloquinone Catabolic Process Cognition	Inflammatory Response Immune Response Signal Transduction Cytokine-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Defense Response To Virus Cellular Response To Virus Interleukin-10-mediated Signaling Pathway Positive Regulation Of Cellular Respiration
Pathways		Phase I - Functionalization of compounds	Other interleukin signaling Interleukin-10 signaling Interleukin-20 family signaling
GWAS		Blood protein levels ( 30072576 ) Lumbar spine bone mineral density ( 22504420 )	Blood protein levels ( 30072576 ) COVID-19 ( 33949668 ) Crohn's disease ( 23128233 ) Multiple sclerosis ( 31604244 ) Narcolepsy ( 23459209 24204295 )
Novel Interactors		10 novel interactors: ANK1 ATP5PO CLU IL10RB ITSN1 KCNE1 KCNJ15 PCP4 RCAN1 SHOX2	2 novel interactors: CBR3 RCAN1
Interacting Genes		7 interacting genes: ARIH2 BICD2 RAB35 RANBP9 S100A10 SDCBP UBC	7 interacting genes: IFNL2 IFNL3 IL10 IL10RA IL22 UCN2 UCN3
Entrez ID		874	3588
HPRD ID		07222	00473
Ensembl ID		ENSG00000159231	ENSG00000243646
Uniprot IDs		O75828 V9HW40	A0A1B0GTI5 A0A1B0GU52 Q08334
PDB IDs		2HRB	3LQM 5T5W 6X93 9BPU 9BPV
GO Terms Enriched among Interactors		Cytoskeletal Anchor Activity Plasma Membrane Apical Dendrite	Corticotropin-releasing Hormone Receptor Binding Extracellular Space Corticotropin-releasing Hormone Receptor 2 Binding Cytokine Activity Interleukin-10-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Response To Glucocorticoid Signaling Receptor Binding Response To Corticosteroid Signal Transduction Negative Regulation Of Inflammatory Response Digestion Response To Steroid Hormone Response To Hormone Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Extracellular Region Positive Regulation Of Receptor Signaling Pathway Via STAT Negative Regulation Of Defense Response Interleukin-10 Receptor Binding Negative Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Response To Lipid Negative Regulation Of Cytokine Activity Interleukin-10 Binding Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Receptor Signaling Pathway Via JAK-STAT Interferon-mediated Signaling Pathway Cellular Response To Virus Cell Surface Receptor Signaling Pathway Via STAT Chronic Inflammatory Response To Antigenic Stimulus Negative Regulation Of Interleukin-18 Production Regulation Of Cytokine Activity Interleukin-10 Receptor Activity Interleukin-22 Receptor Binding Regulation Of Inflammatory Response Negative Regulation Of Autophagy Response To Carbon Monoxide Hormone Activity NADPH Dehydrogenase (quinone) Activity Response To Stress Negative Regulation Of Chronic Inflammatory Response Negative Regulation Of Receptor Binding Negative Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of B Cell Apoptotic Process Negative Regulation Of Interferon-alpha Production Positive Regulation Of Plasma Cell Differentiation 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) Activity Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Negative Regulation Of MHC Class II Biosynthetic Process Hormone-mediated Signaling Pathway