CBR3 and RAB35

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CBR3	RAB35
Gene Name		carbonyl reductase 3	RAB35, member RAS oncogene family
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleoplasm Cytoplasm Cytosol	Golgi Membrane Mitochondrion Endoplasmic Reticulum Membrane Plasma Membrane Coated Pit Endosome Membrane Cell Projection Membrane Melanosome Intercellular Bridge Clathrin-coated Endocytic Vesicle Extracellular Vesicular Exosome
	Molecular Function	3-keto Sterol Reductase Activity Carbonyl Reductase (NADPH) Activity NADPH Binding	GTPase Activity Protein Binding GTP Binding Phosphatidylinositol-4,5-bisphosphate Binding GDP Binding
	Biological Process	Phylloquinone Catabolic Process Cognition Oxidation-reduction Process	Cytokinesis Intracellular Protein Transport ER To Golgi Vesicle-mediated Transport Protein Localization Endosomal Transport Antigen Processing And Presentation Neuron Projection Development Endocytic Recycling Rab Protein Signal Transduction Protein Localization To Endosome Plasma Membrane To Endosome Transport Cellular Response To Nerve Growth Factor Stimulus
Pathways
Drugs
Diseases
GWAS		Bone mineral density ( 22504420)
Protein-Protein Interactions		4 interactors: ARIH2 RAB35 SDCBP UBC	7 interactors: APP C2orf44 CBR3 GNPAT IDH3B PTPRS TBPL1
Entrez ID		874	11021
HPRD ID		07222	05010
Ensembl ID		ENSG00000159231	ENSG00000111737
Uniprot IDs		O75828	G5E9K9 Q15286
PDB IDs		2HRB	3TW8
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Endosomal Transport Ras Protein Signal Transduction Positive Regulation Of Extracellular Vesicular Exosome Assembly Antigen Processing And Presentation Regulation Of Extracellular Vesicular Exosome Assembly Intracellular Transport Plasma Membrane To Endosome Transport Protein Localization To Endosome Cell Development Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Viral Protein Processing Intracellular Signal Transduction Substrate-dependent Cell Migration, Cell Extension Positive Regulation Of MAPK Cascade Establishment Of Localization In Cell Hematopoietic Stem Cell Proliferation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Immune System Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Cellular Response To Growth Factor Stimulus Response To Growth Factor Notch Receptor Processing Protein Modification By Small Protein Conjugation Protein Catabolic Process Endocytic Recycling Virion Assembly Cellular Localization Regulation Of MAPK Cascade Small GTPase Mediated Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Organelle Assembly Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Nerve Growth Factor Stimulus Glycogen Biosynthetic Process Intracellular Transport Of Virus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Protein K63-linked Ubiquitination Substrate-dependent Cell Migration Protein K48-linked Ubiquitination Cellular Polysaccharide Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Neuron Projection Development Polysaccharide Biosynthetic Process Cellular Macromolecule Catabolic Process	Small Molecule Metabolic Process Synapse Assembly Phosphate-containing Compound Metabolic Process Cerebellum Development Metencephalon Development Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Phylloquinone Catabolic Process Hindbrain Development Synapse Organization Brain Development DTTP Biosynthetic Process Cellular Component Assembly Head Development Collateral Sprouting Axon Midline Choice Point Recognition Ether Lipid Biosynthetic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Ketone Catabolic Process Central Nervous System Development Isocitrate Metabolic Process Organophosphate Metabolic Process Neuron Remodeling Ether Lipid Metabolic Process Cognition Deoxyribonucleotide Biosynthetic Process Acrosome Assembly Cofactor Metabolic Process 2-oxoglutarate Metabolic Process Corpus Callosum Development NADH Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Paranodal Junction Assembly Cellular Copper Ion Homeostasis Glycerol Ether Metabolic Process Copper Ion Homeostasis Suckling Behavior Forebrain Development Deoxyribonucleoside Triphosphate Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Phosphatidic Acid Biosynthetic Process Phosphatidic Acid Metabolic Process Spermatid Nucleus Differentiation Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Myelin Assembly Mating Behavior
Tagcloud ?		abcb1 abcb5 abcc5 abcg2 adriamycin anthracycline caesius cardiomyopathy cbr1 comprehensively disposition doxorubicin fuelled glycoside individualizing maximize metabolizing neo peucetius pharmacogenetics pharmacogenomics polygenic pregnane pxr rlip76 slc22a16 streptomyces tailoring var	bait consists dennd5a domains fluorescently gtp gtpases minimal named neurite never outgrowth pc12 plekhm2 rab1 rab1a rab33 rab41 rab6a rabs rbd35 rufy2 run rusc2 succeeded tagged trafficking trapper
Tagcloud (Difference) ?		abcb1 abcb5 abcc5 abcg2 adriamycin anthracycline caesius cardiomyopathy cbr1 comprehensively disposition doxorubicin fuelled glycoside individualizing maximize metabolizing neo peucetius pharmacogenetics pharmacogenomics polygenic pregnane pxr rlip76 slc22a16 streptomyces tailoring var	bait consists dennd5a domains fluorescently gtp gtpases minimal named neurite never outgrowth pc12 plekhm2 rab1 rab1a rab33 rab41 rab6a rabs rbd35 rufy2 run rusc2 succeeded tagged trafficking trapper
Tagcloud (Intersection) ?