CBR3 and KCNJ15

Data Source: HiPPIP (Novel)

		CBR3	KCNJ15
Name		carbonyl reductase 3	potassium inwardly rectifying channel subfamily J member 15
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Cytoplasm Cytosol	Plasma Membrane Membrane Monoatomic Ion Channel Complex
	Molecular Function	3-beta-hydroxysteroid 3-dehydrogenase (NADP+) Activity Carbonyl Reductase (NADPH) Activity Protein Binding NADPH Dehydrogenase (quinone) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor NADPH Binding	Inward Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding
	Biological Process	Xenobiotic Metabolic Process Phylloquinone Catabolic Process Cognition	Monoatomic Ion Transport Potassium Ion Transport Metal Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways		Phase I - Functionalization of compounds	Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs		None	Ritodrine Yohimbine Butamben
GWAS		Blood protein levels ( 30072576 ) Lumbar spine bone mineral density ( 22504420 )	A body shape index ( 34021172 ) Appendicular lean mass ( 33097823 ) Basophil count ( 32888494 ) Basophil percentage of white cells ( 32888494 ) Height ( 31562340 ) Hip circumference adjusted for BMI ( 34021172 ) Metabolite levels ( 23823483 ) Monocyte count ( 32888494 ) Non-response to antidepressants and depression ( 27622933 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Novel Interactors		10 novel interactors: ANK1 ATP5PO CLU IL10RB ITSN1 KCNE1 KCNJ15 PCP4 RCAN1 SHOX2	10 novel interactors: CBR3 CTSE DSCAM KCNE1 LRP8 MTCH1 SLC39A2 SON TOR1B TTC3
Interacting Genes		7 interacting genes: ARIH2 BICD2 RAB35 RANBP9 S100A10 SDCBP UBC	6 interacting genes: IL16 KCNJ16 KCNJ2 KCNJ5 PATJ SNTA1
Entrez ID		874	3772
HPRD ID		07222	03659
Ensembl ID		ENSG00000159231	ENSG00000157551
Uniprot IDs		O75828 V9HW40	Q99712
PDB IDs		2HRB	Not available
GO Terms Enriched among Interactors		Cytoskeletal Anchor Activity Plasma Membrane Apical Dendrite	Regulation Of Monoatomic Ion Transport Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Voltage-gated Potassium Channel Complex Inward Rectifier Potassium Channel Activity Membrane Repolarization Regulation Of Heart Rate Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Membrane Repolarization Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Cardiac Muscle Cell Action Potential Involved In Contraction Monoatomic Ion Channel Complex Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Potassium Ion Import Across Plasma Membrane Potassium Ion Transmembrane Transport Cardiac Conduction Potassium Ion Transport Regulation Of Heart Contraction Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Blood Circulation Inorganic Cation Import Across Plasma Membrane Ventricular Cardiac Muscle Cell Action Potential Action Potential Metal Ion Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Metal Ion Transport Positive Regulation Of Potassium Ion Transmembrane Transport Inorganic Ion Transmembrane Transport Import Across Plasma Membrane Positive Regulation Of Potassium Ion Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Kinesin Binding Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Ammon Gyrus Development Dendrite Morphogenesis Monoatomic Ion Transport Regulation Of System Process Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Regulation Of Potassium Ion Transmembrane Transport Vestibular Nucleus Development Regulation Of Monoatomic Cation Transmembrane Transport Relaxation Of Skeletal Muscle