CBR3 and CLU

		CBR3	CLU
Description		carbonyl reductase 3	clusterin
Image
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Cytoplasm Cytosol	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell Surface Membrane Platelet Alpha Granule Lumen Cytoplasmic Vesicle Mitochondrial Membrane Protein-containing Complex Spherical High-density Lipoprotein Particle Chromaffin Granule Intracellular Membrane-bounded Organelle Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Blood Microparticle Neurofibrillary Tangle Apical Dendrite Perinuclear Endoplasmic Reticulum Lumen
	Molecular Function	3-beta-hydroxysteroid 3-dehydrogenase (NADP+) Activity Carbonyl Reductase (NADPH) Activity Protein Binding NADPH Dehydrogenase (quinone) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor NADPH Binding	Amyloid-beta Binding Signaling Receptor Binding Protein Binding ATP Hydrolysis Activity Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Protein Heterodimerization Activity Receptor Ligand Activity Tau Protein Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding Protein-folding Chaperone Binding Misfolded Protein Binding Protein Sequestering Activity Protein Carrier Chaperone
	Biological Process	Xenobiotic Metabolic Process Phylloquinone Catabolic Process Cognition	Cell Morphogenesis Microglial Cell Activation Release Of Cytochrome C From Mitochondria Negative Regulation Of Activation Of Membrane Attack Complex Immune System Process Immune Complex Clearance Protein Folding Lipid Metabolic Process Apoptotic Process Complement Activation Complement Activation, Classical Pathway Response To Virus Positive Regulation Of Gene Expression Protein Import Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Central Nervous System Myelin Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Reverse Cholesterol Transport Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Complement Activation Positive Regulation Of Receptor-mediated Endocytosis Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Chaperone-mediated Protein Complex Assembly Response To Misfolded Protein Microglial Cell Proliferation Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Negative Regulation Of Release Of Cytochrome C From Mitochondria Intrinsic Apoptotic Signaling Pathway Amyloid-beta Clearance Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Formation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Amyloid-beta Formation Regulation Of Neuronal Signal Transduction Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Amyloid Fibril Formation Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Phase I - Functionalization of compounds	Platelet degranulation Terminal pathway of complement Antimicrobial peptides Regulation of Complement cascade
Drugs			Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 30072576) Lumbar spine bone mineral density ( 22504420)	Alzheimer's disease ( 19734902 19734903 21627779 31473137) Alzheimer's disease (late onset) ( 21460841 24162737 30617256 28714976) Alzheimer's disease in APOE e4+ carriers ( 25778476) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 33589840 30617256) Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Family history of Alzheimer's disease ( 30617256) Lung adenocarcinoma ( 28604730) Lung cancer in ever smokers ( 28604730) Panic disorder ( 19165232) Refractive error ( 32231278) Schizophrenia ( 29483656 25056061) Smoking behaviour (cigarettes smoked per day) ( 31089300) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		7 interacting genes: ARIH2 BICD2 RAB35 RANBP9 S100A10 SDCBP UBC	62 interacting genes: APP BAG6 BTG3 C7 C8B C9 CBY1 CD209 CLUAP1 CYP2E1 DISC1 DLG4 DSCAM DSCR9 DYRK1A ELN EPPIN ETS2 FOS GRB2 HSPA13 HSPD1 HUNK IL24 KATNA1 KEAP1 KLF11 KNSTRN LCOR LEP LEPR LIG4 LRP1 LRP2 LRP8 LYZ MAPK9 MDM2 MMP25 MSRB1 PAXIP1 PLXNA4 POLR1C PON1 PRNP RBBP8 RPL23 RSPH1 SHANK3 SRPK2 SYVN1 TGFBR1 TGFBR2 TNIK TREM2 TSC22D4 TTR UBC VHL VLDLR XRCC6 ZWINT
Entrez ID		874	1191
HPRD ID		07222	01706
Ensembl ID		ENSG00000159231	ENSG00000120885
Uniprot IDs		O75828 V9HW40	P10909
PDB IDs		2HRB	7ZET 7ZEU
Enriched GO Terms of Interacting Partners?		Cytoskeletal Anchor Activity Plasma Membrane Apical Dendrite	Apolipoprotein Binding Low-density Lipoprotein Particle Receptor Activity Cell Projection Morphogenesis Neuron Projection Organization Neuron Projection Morphogenesis Positive Regulation Of Developmental Process Positive Regulation Of Cell Differentiation Receptor Complex Cell Activation Positive Regulation Of Protein Catabolic Process Membrane Attack Complex Other Organism Cell Membrane Regulation Of Proteolysis Cargo Receptor Activity Response To Stress Regulation Of Immune Response Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Signal Transduction Dendritic Spine Organization System Development Endocytosis Clathrin-coated Pit Memory Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Development High-density Lipoprotein Particle Binding Anatomical Structure Morphogenesis Protein-containing Complex Binding Regulation Of Cell Projection Organization Intracellular Signal Transduction Complement Activation, GZMK Pathway Nervous System Development Cellular Response To Growth Factor Stimulus Reelin Receptor Activity Positive Regulation Of Proteolysis Transmembrane Transporter Complex Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cell Surface Receptor Signaling Pathway Cell Projection Organization Positive Regulation Of Cell Activation Immune Effector Process Immune System Process Postsynapse Organization Regulation Of Immune System Process Regulation Of Developmental Process Complement Activation, Alternative Pathway Terpenoid Metabolic Process Cellular Response To Oxygen-containing Compound Cognition
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