UBASH3A and SLC37A1

		UBASH3A	SLC37A1
Description		ubiquitin associated and SH3 domain containing A	solute carrier family 37 member 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Organelle Membrane
	Molecular Function	Protein Binding	Antiporter Activity Transmembrane Transporter Activity Glucose 6-phosphate:phosphate Antiporter Activity
	Biological Process	Regulation Of Cytokine Production Negative Regulation Of T Cell Receptor Signaling Pathway	Glucose-6-phosphate Transport Phosphate Ion Transmembrane Transport Transmembrane Transport
Pathways			Gluconeogenesis
Drugs
Diseases
GWAS		Addison's disease ( 33574239) Asthma ( 32296059) Autoimmune traits (pleiotropy) ( 30572963) Celiac disease ( 22057235 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Diverticular disease ( 30177863) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte count ( 32888494) Medication use (thyroid preparations) ( 31015401) Primary sclerosing cholangitis ( 27992413) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Type 1 diabetes ( 18840781 30572963 25751624 21829393 19430480) Vitiligo ( 27723757 20410501)
Interacting Genes		105 interacting genes: ARRDC1 ARRDC3 ATF6 BCAR3 CBLB CBS CCDC33 CD3E COPS9 CUEDC1 CXXC5 DAZAP2 DDIT4L DISC1 DLG1 DLGAP4 DNM2 DTX3 EHMT2 FADS6 FAM83A FGFR1OP2 GFAP GOLGA6L9 HSP90AA1 HSP90B1 HSPD1 IKBKG ISY1-RAB43 KCNE1 KCTD1 KIAA0408 KPRP KRT14 KRT31 KRT32 KRT35 KRT39 KRT40 LCN2 LNX1 LZTS1 LZTS2 MAP3K7 MKRN1 MTIF2 N4BP3 NEUROD2 NSMF PDE7A PFDN2 PLEKHB2 PMEPA1 PNMA5 PRDM6 PRKN PSMC1 PSMC4 REL RNF216 RNF41 SF3B4 SH3RF1 SHISA6 SLA2 SLC4A3 SNRNP48 SOS1 SOS2 SPMIP6 SPRY1 SPRY2 SPRYD7 STX11 TAOK1 TAX1BP1 TEKT1 TEKT4 TIMM44 TMCO2 TMEM239 TP53BP2 TP63 TRIM27 TRIM37 TRIM5 TRIM50 TRIM8 TUBB8 UBB UBC UBE2L3 VCP VPS37B VPS72 WAS WASL WBP11 YPEL3 ZBTB42 ZC2HC1C ZIC3 ZNF219 ZNF474 ZRANB1	5 interacting genes: ADRB2 GPR35 GPR37 HTR2B SHBG
Entrez ID		53347	54020
HPRD ID		06904	10479
Ensembl ID		ENSG00000160185	ENSG00000160190
Uniprot IDs		P57075	P57057
PDB IDs		2CRN 5WDI
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Inclusion Body Assembly Post-translational Protein Modification Ubiquitin Protein Ligase Activity Intermediate Filament Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Identical Protein Binding Aggresome Assembly Proteolysis Involved In Protein Catabolic Process Morphogenesis Of An Epithelium Positive Regulation Of Catabolic Process Sperm Plasma Membrane WW Domain Binding Protein Binding Regulation Of Post-translational Protein Modification Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Keratin Filament Canonical NF-kappaB Signal Transduction Negative Regulation Of Membrane Tubulation Cytosol Cytoskeleton Organization Tissue Morphogenesis Positive Regulation Of Protein Catabolic Process Organelle Organization Modification-dependent Protein Catabolic Process Intermediate Filament Protein Polyubiquitination Macromolecule Catabolic Process Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Regulation Of Intracellular Signal Transduction SH3 Domain Binding P53 Binding Protein Localization To Mitochondrion Linear Polyubiquitin Binding Regulation Of Protein Catabolic Process Protein Polymerization Regulation Of Autophagy Regulation Of Signal Transduction Suppression Of Viral Release By Host Positive Regulation Of Protein Metabolic Process Regulation Of Type I Interferon Production Positive Regulation Of Post-translational Protein Modification Ubiquitin-protein Transferase Activity	G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Smooth Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of MAPK Cascade Positive Regulation Of Mini Excitatory Postsynaptic Potential Response To Psychosocial Stress Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Blood Vessel Diameter Maintenance Beta-adrenergic Receptor Activity Norepinephrine Binding Regulation Of Tube Size Positive Regulation Of Lipophagy Regulation Of MAPK Cascade AMPA Selective Glutamate Receptor Signaling Pathway Beta2-adrenergic Receptor Activity Prosaposin Receptor Activity Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process G Protein-coupled Serotonin Receptor Complex Intestine Smooth Muscle Contraction Androgen Binding Muscle Contraction Receptor Complex Positive Regulation Of Dopamine Metabolic Process Positive Regulation Of Autophagosome Maturation Heat Generation Locomotion Involved In Locomotory Behavior Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway C-X-C Chemokine Receptor Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Phospholipase C-activating Serotonin Receptor Signaling Pathway Muscle System Process Adrenergic Receptor Activity Dopamine Biosynthetic Process Diet Induced Thermogenesis Vascular Process In Circulatory System Serotonin Binding Serotonin Receptor Signaling Pathway Positive Regulation Of Phospholipid Biosynthetic Process Adenylate Cyclase Binding Negative Regulation Of Smooth Muscle Contraction Serotonin Receptor Activity Neural Crest Cell Differentiation Negative Regulation Of Multicellular Organism Growth G Protein-coupled Serotonin Receptor Activity Positive Regulation Of Intracellular Signal Transduction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Autophagosome Maturation Circulatory System Process
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