AREG and UBQLN4

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		AREG	UBQLN4
Gene Name		amphiregulin	ubiquilin 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cell Surface Integral Component Of Membrane	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Nuclear Proteasome Complex Cytosolic Proteasome Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Cytokine Activity Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Protein Binding Polyubiquitin Binding Identical Protein Binding
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Cell Proliferation Positive Regulation Of Cell Proliferation Glial Cell Proliferation Neuron Projection Development Response To Estradiol Positive Regulation Of Phosphorylation Response To Hydrogen Peroxide Response To Peptide Hormone Negative Regulation Of Osteoblast Differentiation Positive Regulation Of DNA Replication Response To Glucocorticoid Response To CAMP Dichotomous Subdivision Of Terminal Units Involved In Mammary Gland Duct Morphogenesis Mammary Gland Branching Involved In Thelarche Mammary Gland Alveolus Development Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation	Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS		Breast size ( 22747683)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		8 interactors: APP CCND3 EGFR KRTAP10-3 MMP9 UBQLN4 WDR92 WT1	157 interactors: ADAM33 ADPGK AGR2 ANKRD13D AREG ARL4C ATPIF1 ATXN1 BAG6 BPIFA1 C11orf49 C1orf94 C1QTNF1 CACNA1G CCDC107 CCDC134 CCDC136 CCDC14 CCDC33 CCL21 CD99 CDSN CEND1 COL8A1 COPB1 CPSF6 CRIPT CSTF2 CSTF2T CTSB CYB5R1 DAZAP2 DKK3 DMPK DNAJB11 DTX2 EAPP EDN1 EEF1A1 EFEMP2 ELF5 EPDR1 ERP27 ERP29 FA2H FGFBP1 FKBP2 FKBP7 FZD7 GABRD GDI1 GKAP1 GPX7 HAVCR1 HGS HK2 HSPA13 HSPA5 IGFBP6 IGHM IGLC1 IMMT IMPDH2 ITPRIPL1 KLHL26 KLHL42 LAT2 MDK MDM2 MIEF2 MIF4GD MLLT6 MOAP1 MYDGF NAE1 NME3 NOMO1 NOMO3 NOTCH2NL NPHP1 NPPA NXF1 OAT ORC5 PBXIP1 PCDH17 PCDH8 PDIA5 PDLIM7 PELI2 PICK1 PIN1 PIP4K2B PLA2G16 PMEPA1 PNMA1 PPIB PPIC PRL PRPF40A PSMD4 PTN PTPRN PTPRN2 QSOX1 RAD23A RAI2 RBM10 RIC8A RNF11 RNPS1 ROBO2 RPN1 RSRC2 RUNX1T1 RXRA SCAF1 SCG2 SCG5 SCMH1 SEMG1 SERPINE1 SERPINH1 SERPINI2 SMAD3 SMAD9 SMARCB1 SPAG8 SPINT1 SPP1 SRGN SRSF2 STAM2 STMN1 SUPT20H TFF1 TGFB1I1 TNFRSF14 TNRC6B TRAF2 TRIB2 TRIM32 UBQLN1 UBQLN2 UBR7 UNC119 UROS USMG5 VIP WAC YWHAQ ZBTB22 ZDHHC3 ZFPM2 ZG16 ZG16B ZNF205
Entrez ID		374	56893
HPRD ID		00093	05670
Ensembl ID		ENSG00000109321	ENSG00000160803
Uniprot IDs		P15514	B4DZF6 Q9NRR5
PDB IDs		2RNL
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Morphogenesis Involved In Differentiation Positive Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Cell Morphogenesis Axon Guidance Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Locomotion Regulation Of ERBB Signaling Pathway Reproductive Process Alkanesulfonate Metabolic Process Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Axonogenesis Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Axon Development Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Visceral Serous Pericardium Development Synaptic Growth At Neuromuscular Junction Posterior Mesonephric Tubule Development Adrenal Cortex Formation Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Positive Regulation Of Metanephric Ureteric Bud Development Thorax And Anterior Abdomen Determination Astrocyte Activation Neuron Projection Morphogenesis Cell Activation Regulation Of Protein Binding Negative Regulation Of Glomerular Mesangial Cell Proliferation Negative Regulation Of Glomerulus Development Collateral Sprouting In Absence Of Injury Regulation Of Protein Kinase Activity Cell Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Positive Regulation Of Receptor Binding Activation Of Phospholipase A2 Activity Zygotic Determination Of Anterior/posterior Axis, Embryo Regulation Of Kinase Activity Neuron Projection Development Positive Regulation Of Phospholipase A2 Activity Positive Regulation Of Keratinocyte Migration Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Cell Proliferation Involved In Kidney Development Cell Projection Morphogenesis Cell Part Morphogenesis	Regulation Of Cellular Process Response To Stress Positive Regulation Of Cellular Metabolic Process Response To Stimulus Signaling Signal Transduction Cell Communication Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Multicellular Organismal Development Positive Regulation Of Metabolic Process Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Cell Proliferation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transport Organ Development Positive Regulation Of Mitochondrion Organization Regulation Of Cellular Localization Regulation Of Proteolysis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Developmental Process Response To Organic Substance Tissue Development Regulation Of Metabolic Process Positive Regulation Of Gene Expression Anatomical Structure Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Behavior Regulation Of Phosphorus Metabolic Process System Development Protein Peptidyl-prolyl Isomerization Regulation Of Signaling Negative Regulation Of Cell Proliferation Regulation Of Body Fluid Levels Regulation Of Chemotaxis Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Cellular Localization Defense Response Regulation Of Mitochondrion Organization Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cellular Component Organization
Tagcloud ?		18k amphiregulin atf3 biomarker biomarkers bleomycin candidate chemotherapy cisplatin clustered damage endothelial equalled etoposide gdf hmec hscrp mellitus micro microarrays preclinical qrt sets testicular unbiased untreated von vwf willebrand
Tagcloud (Difference) ?		18k amphiregulin atf3 biomarker biomarkers bleomycin candidate chemotherapy cisplatin clustered damage endothelial equalled etoposide gdf hmec hscrp mellitus micro microarrays preclinical qrt sets testicular unbiased untreated von vwf willebrand
Tagcloud (Intersection) ?