AREG and MMP9

Number of citations of the paper that reports this interaction (PMID 10389762)
10

Data Source:
HPRD (in vivo)

		AREG	MMP9
Gene Name		amphiregulin	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cell Surface Integral Component Of Membrane	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Cytokine Activity Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Collagen Binding Zinc Ion Binding Identical Protein Binding
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Cell Proliferation Positive Regulation Of Cell Proliferation Glial Cell Proliferation Neuron Projection Development Response To Estradiol Positive Regulation Of Phosphorylation Response To Hydrogen Peroxide Response To Peptide Hormone Negative Regulation Of Osteoblast Differentiation Positive Regulation Of DNA Replication Response To Glucocorticoid Response To CAMP Dichotomous Subdivision Of Terminal Units Involved In Mammary Gland Duct Morphogenesis Mammary Gland Branching Involved In Thelarche Mammary Gland Alveolus Development Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation	Skeletal System Development Ossification Proteolysis Axon Guidance Embryo Implantation Extracellular Matrix Disassembly Extracellular Matrix Organization Macrophage Differentiation Collagen Catabolic Process Endodermal Cell Differentiation Positive Regulation Of Apoptotic Process Ephrin Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Keratinocyte Migration Positive Regulation Of Receptor Binding Negative Regulation Of Cation Channel Activity
Pathways			Signaling by SCF-KIT EPH-ephrin mediated repulsion of cells Axon guidance Collagen formation Collagen degradation Activation of Matrix Metalloproteinases EPH-Ephrin signaling Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs			Marimastat Minocycline Captopril Glucosamine 2-Amino-N,3,3-Trimethylbutanamide 2-{[Formyl(Hydroxy)Amino]Methyl}-4-Methylpentanoic Acid 5-(4-PHENOXYPHENYL)-5-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PYRIMIDINE-2,4,6(2H,3H)-TRIONE (2R)-2-AMINO-3,3,3-TRIFLUORO-N-HYDROXY-2-{[(4-PHENOXYPHENYL)SULFONYL]METHYL}PROPANAMIDE (3R)-4,4-DIFLUORO-3-[(4-METHOXYPHENYL)SULFONYL]BUTANOIC ACID
Diseases
GWAS		Breast size ( 22747683)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		8 interactors: APP CCND3 EGFR KRTAP10-3 MMP9 UBQLN4 WDR92 WT1	32 interactors: AREG BTC CD44 COL1A1 COL1A2 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 CXCL1 CXCL5 CXCL6 CXCL8 EPHB2 FN1 HAPLN1 KISS1 LCN2 MMP10 MMP26 MMP7 PLG PRSS2 PZP RECK TFPI TGFB1 THBS1 THBS2 TIMP3
Entrez ID		374	4318
HPRD ID		00093	00387
Ensembl ID		ENSG00000109321	ENSG00000100985
Uniprot IDs		P15514	P14780
PDB IDs		2RNL	1GKC 1GKD 1ITV 1L6J 1LKG 2OVX 2OVZ 2OW0 2OW1 2OW2 4H1Q 4H2E 4H3X 4H82 4HMA
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Morphogenesis Involved In Differentiation Positive Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Cell Morphogenesis Axon Guidance Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Locomotion Regulation Of ERBB Signaling Pathway Reproductive Process Alkanesulfonate Metabolic Process Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Axonogenesis Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Axon Development Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Visceral Serous Pericardium Development Synaptic Growth At Neuromuscular Junction Posterior Mesonephric Tubule Development Adrenal Cortex Formation Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Positive Regulation Of Metanephric Ureteric Bud Development Thorax And Anterior Abdomen Determination Astrocyte Activation Neuron Projection Morphogenesis Cell Activation Regulation Of Protein Binding Negative Regulation Of Glomerular Mesangial Cell Proliferation Negative Regulation Of Glomerulus Development Collateral Sprouting In Absence Of Injury Regulation Of Protein Kinase Activity Cell Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Positive Regulation Of Receptor Binding Activation Of Phospholipase A2 Activity Zygotic Determination Of Anterior/posterior Axis, Embryo Regulation Of Kinase Activity Neuron Projection Development Positive Regulation Of Phospholipase A2 Activity Positive Regulation Of Keratinocyte Migration Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Cell Proliferation Involved In Kidney Development Cell Projection Morphogenesis Cell Part Morphogenesis	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Locomotion Movement Of Cell Or Subcellular Component Blood Vessel Development Vasculature Development Catabolic Process Regulation Of Body Fluid Levels Response To External Stimulus Chemotaxis Cell Migration Positive Regulation Of Chemotaxis Cell Motility Positive Regulation Of Behavior Immune System Process Regulation Of Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Cellular Response To Organic Substance Negative Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Blood Coagulation Negative Regulation Of Peptidase Activity Inflammatory Response Hemostasis Defense Response Cardiovascular System Development Positive Regulation Of Leukocyte Migration Regulation Of Behavior Platelet Activation Response To Organic Substance Positive Regulation Of Cell Migration Response To Cytokine Positive Regulation Of Cell Motility Response To Stress Positive Regulation Of Cellular Component Movement Negative Regulation Of Proteolysis Positive Regulation Of Locomotion Negative Regulation Of Protein Processing Regulation Of Leukocyte Migration Immune Response Leukocyte Migration Regulation Of Endopeptidase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Cytokine Stimulus Negative Regulation Of Hydrolase Activity
Tagcloud ?		18k amphiregulin atf3 biomarker biomarkers bleomycin candidate chemotherapy cisplatin clustered damage endothelial equalled etoposide gdf hmec hscrp mellitus micro microarrays preclinical qrt sets testicular unbiased untreated von vwf willebrand	alkaline alp ccd cleidocranial cocultured ctr ctsk dental dspp dysplasia heterozygous interfered mineralization mineralized mononuclear nodules ocn odontoblast opg osteoblast osteoclast partly pulp rankl remodeling retention runx2 teeth tooth
Tagcloud (Difference) ?		18k amphiregulin atf3 biomarker biomarkers bleomycin candidate chemotherapy cisplatin clustered damage endothelial equalled etoposide gdf hmec hscrp mellitus micro microarrays preclinical qrt sets testicular unbiased untreated von vwf willebrand	alkaline alp ccd cleidocranial cocultured ctr ctsk dental dspp dysplasia heterozygous interfered mineralization mineralized mononuclear nodules ocn odontoblast opg osteoblast osteoclast partly pulp rankl remodeling retention runx2 teeth tooth
Tagcloud (Intersection) ?