AREG

Name	amphiregulin
Structure
Interactors	10 interactors: APP CCND3 CYSRT1 DNAAF10 EGFR KRTAP10-3 KRTAP10-8 MMP9 UBQLN4 WT1
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Cytokine Activity Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Ligand Activity
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Positive Regulation Of Keratinocyte Proliferation Glial Cell Proliferation Neuron Projection Development Response To Estradiol ERBB2-EGFR Signaling Pathway Positive Regulation Of Phosphorylation Response To Hydrogen Peroxide Response To Peptide Hormone Negative Regulation Of Osteoblast Differentiation Response To Glucocorticoid Response To CAMP Dichotomous Subdivision Of Terminal Units Involved In Mammary Gland Duct Morphogenesis Mammary Gland Branching Involved In Thelarche Mammary Gland Alveolus Development Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation
Pathways	PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation COPII-mediated vesicle transport EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade Cargo concentration in the ER PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling NFE2L2 regulating tumorigenic genes Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells
GWAS	Blond vs. brown/black hair color ( 30531825 ) Breast size ( 22747683 27182965 ) Mammographic density (dense area) ( 25342443 ) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472 )
Entrez ID	374
HPRD ID	00093
Ensembl ID	ENSG00000109321
Uniprot IDs	P15514
PDB IDs	2RNL
GO Terms Enriched among Interactors ?	Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Response To UV-A Positive Regulation Of Mitotic Cell Cycle Acetylcholine Receptor Activator Activity Amyloid-beta Complex Positive Regulation Of Phosphate Metabolic Process Growth Cone Lamellipodium Cellular Response To Oxygen-containing Compound Response To Light Stimulus Regulation Of Response To Calcium Ion Amylin Binding Response To Amyloid-beta Regulation Of Protein Metabolic Process Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP Regulation Of Protein Catabolic Process Lipoprotein Particle Positive Regulation Of Cell Cycle Extracellular Matrix Organization Positive Regulation Of Protein Import Extracellular Structure Organization Response To CAMP Identical Protein Binding Positive Regulation Of Cell Cycle G1/S Phase Transition Cyclin D3-CDK6 Complex Cyclin D3-CDK4 Complex Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of MiRNA Metabolic Process Regulation Of ERBB Signaling Pathway Positive Regulation Of MiRNA Transcription Shc-EGFR Complex Multivesicular Body, Internal Vesicle Lumen Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Nuclear Proteasome Complex PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Cell Population Proliferation Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization