CTNNA1 and CDH2

Number of citations of the paper that reports this interaction (PubMedID 12604612)
0

Data Source:
HPRD (in vitro)

		CTNNA1	CDH2
Description		catenin alpha 1	cadherin 2
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Zonula Adherens Focal Adhesion Intercalated Disc Actin Cytoskeleton Membrane Catenin Complex Flotillin Complex Lamellipodium Cell Junction Anchoring Junction Plasma Membrane Protein Complex	Cytoplasm Endoplasmic Reticulum Lumen Plasma Membrane Cell-cell Junction Adherens Junction Fascia Adherens Focal Adhesion Cell Surface Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Catenin Complex Lamellipodium Cell Junction Desmosome Cortical Actin Cytoskeleton Extracellular Matrix Sarcolemma Neuron Projection Plasma Membrane Raft Apical Part Of Cell Synapse Anchoring Junction Presynapse
	Molecular Function	RNA Binding Structural Molecule Activity Protein Binding Beta-catenin Binding Cytoskeletal Protein Binding Vinculin Binding Identical Protein Binding Protein-containing Complex Binding Gamma-catenin Binding Cadherin Binding Actin Filament Binding	RNA Binding Calcium Ion Binding Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding Identical Protein Binding Alpha-catenin Binding Gamma-catenin Binding Cadherin Binding Metal Ion Binding
	Biological Process	Ovarian Follicle Development Apoptotic Process Cell Adhesion Establishment Or Maintenance Of Cell Polarity Smoothened Signaling Pathway Integrin-mediated Signaling Pathway Neuroblast Proliferation Negative Regulation Of Neuroblast Proliferation Intracellular Protein Localization Male Gonad Development Gap Junction Assembly Cell Migration Axon Regeneration Regulation Of Cell Population Proliferation Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Apical Junction Assembly Response To Estrogen Positive Regulation Of Smoothened Signaling Pathway Cell Motility Cellular Response To Indole-3-methanol Epithelial Cell-cell Adhesion Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell-cell Adhesion Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell Motility Negative Regulation Of Integrin-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Cell Morphogenesis Type B Pancreatic Cell Development Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Synapse Assembly Glial Cell Differentiation Neural Crest Cell Development Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Telencephalon Development Cerebral Cortex Development Adherens Junction Organization Detection Of Muscle Stretch Positive Regulation Of MAPK Cascade Cell-cell Adhesion Mediated By Cadherin Blood Vessel Morphogenesis Brain Morphogenesis Homeostasis Of Number Of Cells Striated Muscle Cell Differentiation Radial Glial Cell Differentiation Neuroepithelial Cell Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Mesenchymal Cell Migration Synaptic Vesicle Clustering Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Neuronal Stem Cell Population Maintenance Cell-cell Adhesion Regulation Of Postsynaptic Density Protein 95 Clustering Positive Regulation Of Synaptic Vesicle Clustering
Pathways		Adherens junctions interactions VEGFR2 mediated vascular permeability Myogenesis Myogenesis RHO GTPases activate IQGAPs Regulation of CDH11 function Regulation of CDH19 Expression and Function Regulation of CDH1 Function Degradation of CDH1 CDH11 homotypic and heterotypic interactions	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Adherens junctions interactions Myogenesis Myogenesis Post-translational protein phosphorylation Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) General risk tolerance (MTAG) ( 30643258) Malaria ( 31844061) Schizophrenia ( 25056061)	Breast cancer ( 29058716) Breast cancer (estrogen-receptor negative) ( 29058716) Daytime nap ( 33568662) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Lung function (FVC) ( 24023788) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Optic disc size ( 31809533) Periodontal disease-related phenotype (Socransky) ( 24347629) PR interval ( 32439900) Refractive error ( 32231278) Response to hepatitis B vaccine ( 29534301) Resting heart rate ( 27798624) Systemic lupus erythematosus ( 32771030) Temperament (bipolar disorder) ( 22365631) Type 2 diabetes ( 31049640) Urinary albumin-to-creatinine ratio in diabetes ( 31511532) vWF and FVIII levels ( 21810271)
Interacting Genes		55 interacting genes: ACTN1 AFDN AJUBA AKT1 ALDOB APP ARMC8 BAAT CA9 CCDC180 CDC42 CDH1 CDH15 CDH2 CDH3 CDH5 CSNK2A1 CTBP1 CTNNB1 CTSV DLG1 DYRK1A EIF4ENIF1 F2RL1 FBP1 FBP2 FRAT2 HRAS HSD17B3 HSPA13 JUP LRATD2 MAP2K1 MTNR1A MTNR1B NANS PKD1 PSEN1 RBM26 RNF10 SASH1 SFRP2 SFRP4 SMAD1 SPTAN1 SPTBN1 STX17 TDRD7 TJP1 TJP2 UBE2I VCL ZGPAT ZNF189 ZNF510	23 interacting genes: ARHGAP32 ARVCF BOC CDH11 CDH4 CDON CREBBP CTNNA1 CTNNB1 CTNND2 EXOC5 FGFR4 GNA12 GNA13 GRIK2 GRIN1 GRIN2D JUP LRRC7 PIK3R1 PKP4 PTPN1 UBC
Entrez ID		1495	1000
HPRD ID		00285	00226
Ensembl ID		ENSG00000044115	ENSG00000170558
Uniprot IDs		A0A384MDY0 B4DKT9 B4DU00 G3XAM7 P35221	C9J126 P19022
PDB IDs		1H6G 4EHP 4IGG 6UPV 6V2O 6V2P 7UTJ 9BL2 9BL3 9BL4
Enriched GO Terms of Interacting Partners?		Cell-cell Junction Organization Cell Junction Organization Adherens Junction Cadherin Binding Adherens Junction Organization Cell Junction Assembly Cell-cell Junction Assembly Cell Junction Cell-cell Adhesion Catenin Complex Cell-cell Junction Cell-cell Adhesion Mediated By Cadherin Alpha-catenin Binding Anchoring Junction Cell Adhesion Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Fascia Adherens Anatomical Structure Morphogenesis Regulation Of Cell Motility Regulation Of Protein Localization Glutamatergic Synapse Regulation Of Locomotion Beta-catenin Binding Regulation Of Cell Migration Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Component Organization Plasma Membrane Cellular Response To Indole-3-methanol Regulation Of Supramolecular Fiber Organization Cell Development Regulation Of Cell Population Proliferation Response To Indole-3-methanol Cytoplasm Cortical Actin Cytoskeleton Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Wnt Signaling Pathway Positive Regulation Of Gene Expression Regulation Of DNA-templated Transcription Developmental Process Regulation Of RNA Biosynthetic Process Regulation Of Cell Adhesion Negative Regulation Of Signal Transduction Regulation Of Canonical Wnt Signaling Pathway Regulation Of Multicellular Organismal Development Positive Regulation Of Angiogenesis Positive Regulation Of Macromolecule Biosynthetic Process Protein Kinase Binding Fructose 1,6-bisphosphate Metabolic Process Regulation Of RNA Metabolic Process	Adherens Junction Cell-cell Adhesion Cadherin Binding Cell Adhesion Catenin Complex Regulation Of Cell Communication Regulation Of Signaling Plasma Membrane Regulation Of Signal Transduction Cell-cell Junction Assembly Cellular Response To Indole-3-methanol Response To Indole-3-methanol Cell-cell Junction Organization Glutamate-gated Calcium Ion Channel Activity Cell-cell Junction Cell Surface Receptor Signaling Pathway Postsynaptic Membrane Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Signaling Cassette Postsynaptic Density Anatomical Structure Morphogenesis Cell Junction Assembly Excitatory Postsynaptic Potential D5 Dopamine Receptor Binding Cell Junction Organization Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Signal Transduction Catenin-TCF7L2 Complex Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Beta-catenin Binding Ligand-gated Monoatomic Ion Channel Activity Anchoring Junction Cellular Response To Oxygen-containing Compound Signal Transduction Cell-cell Adhesion Mediated By Cadherin Ligand-gated Ion Channel Signaling Pathway Rho-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Synaptic Transmission, Glutamatergic Regulation Of Neuroblast Proliferation Presynaptic Membrane Neuroblast Proliferation Intercalated Disc NMDA Glutamate Receptor Activity Glutamate Binding Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission
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