CTNNA1 and AFDN

Number of citations of the paper that reports this interaction (PubMedID 11907041)
40

Data Source:
HPRD (in vitro)

		CTNNA1	AFDN
Description		catenin alpha 1	afadin, adherens junction formation factor
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Zonula Adherens Focal Adhesion Intercalated Disc Actin Cytoskeleton Membrane Catenin Complex Flotillin Complex Lamellipodium Cell Junction Anchoring Junction Plasma Membrane Protein Complex	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Nuclear Speck Cell Junction Cell-cell Contact Zone Pore Complex Tight Junction Anchoring Junction
	Molecular Function	RNA Binding Structural Molecule Activity Protein Binding Beta-catenin Binding Cytoskeletal Protein Binding Vinculin Binding Identical Protein Binding Protein-containing Complex Binding Gamma-catenin Binding Cadherin Binding Actin Filament Binding	Protein Binding Small GTPase Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding
	Biological Process	Ovarian Follicle Development Apoptotic Process Cell Adhesion Establishment Or Maintenance Of Cell Polarity Smoothened Signaling Pathway Integrin-mediated Signaling Pathway Neuroblast Proliferation Negative Regulation Of Neuroblast Proliferation Intracellular Protein Localization Male Gonad Development Gap Junction Assembly Cell Migration Axon Regeneration Regulation Of Cell Population Proliferation Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Apical Junction Assembly Response To Estrogen Positive Regulation Of Smoothened Signaling Pathway Cell Motility Cellular Response To Indole-3-methanol Epithelial Cell-cell Adhesion Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell-cell Adhesion Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell Motility Negative Regulation Of Integrin-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Cell Differentiation Negative Regulation Of Cell Migration Regulation Of Protein Localization Cell Junction Organization Cell-cell Adhesion Mediated By Cadherin Pore Complex Assembly Establishment Of Protein Localization To Plasma Membrane Bicellular Tight Junction Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Adherens junctions interactions VEGFR2 mediated vascular permeability Myogenesis Myogenesis RHO GTPases activate IQGAPs Regulation of CDH11 function Regulation of CDH19 Expression and Function Regulation of CDH1 Function Degradation of CDH1 CDH11 homotypic and heterotypic interactions
Drugs			(5R)-2-sulfanyl-5-[4-(trifluoromethyl)benzyl]-1,3-thiazol-4(5H)-one
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) General risk tolerance (MTAG) ( 30643258) Malaria ( 31844061) Schizophrenia ( 25056061)	Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906)
Interacting Genes		55 interacting genes: ACTN1 AFDN AJUBA AKT1 ALDOB APP ARMC8 BAAT CA9 CCDC180 CDC42 CDH1 CDH15 CDH2 CDH3 CDH5 CSNK2A1 CTBP1 CTNNB1 CTSV DLG1 DYRK1A EIF4ENIF1 F2RL1 FBP1 FBP2 FRAT2 HRAS HSD17B3 HSPA13 JUP LRATD2 MAP2K1 MTNR1A MTNR1B NANS PKD1 PSEN1 RBM26 RNF10 SASH1 SFRP2 SFRP4 SMAD1 SPTAN1 SPTBN1 STX17 TDRD7 TJP1 TJP2 UBE2I VCL ZGPAT ZNF189 ZNF510	39 interacting genes: BCR CTNNA1 DSCAM EPHA7 EPHB2 EPHB3 EPHB6 F11R HRAS JAG1 LMO2 MRAS NECTIN1 NECTIN2 NECTIN3 NECTIN4 NRXN1 NRXN2 NRXN3 PFN1 PICK1 RALGDS RAP1A RAP1GAP RAP2A RIN1 RIT1 RIT2 RNF10 RRAS RRAS2 SMAD2 SORBS1 SORBS2 SSX2IP TJP1 USP9X YWHAB YWHAG
Entrez ID		1495	4301
HPRD ID		00285	01164
Ensembl ID		ENSG00000044115	ENSG00000130396
Uniprot IDs		A0A384MDY0 B4DKT9 B4DU00 G3XAM7 P35221	A0A1P7ZIN0 A0A804HJ20 A8MQ02 G1UI22 J3KN01 P55196
PDB IDs		1H6G 4EHP 4IGG 6UPV 6V2O 6V2P 7UTJ 9BL2 9BL3 9BL4	1T2M 1XZ9 2AIN 2EXG 5A6C 7QCR
Enriched GO Terms of Interacting Partners?		Cell-cell Junction Organization Cell Junction Organization Adherens Junction Cadherin Binding Adherens Junction Organization Cell Junction Assembly Cell-cell Junction Assembly Cell Junction Cell-cell Adhesion Catenin Complex Cell-cell Junction Cell-cell Adhesion Mediated By Cadherin Alpha-catenin Binding Anchoring Junction Cell Adhesion Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Fascia Adherens Anatomical Structure Morphogenesis Regulation Of Cell Motility Regulation Of Protein Localization Glutamatergic Synapse Regulation Of Locomotion Beta-catenin Binding Regulation Of Cell Migration Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Component Organization Plasma Membrane Cellular Response To Indole-3-methanol Regulation Of Supramolecular Fiber Organization Cell Development Regulation Of Cell Population Proliferation Response To Indole-3-methanol Cytoplasm Cortical Actin Cytoskeleton Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Wnt Signaling Pathway Positive Regulation Of Gene Expression Regulation Of DNA-templated Transcription Developmental Process Regulation Of RNA Biosynthetic Process Regulation Of Cell Adhesion Negative Regulation Of Signal Transduction Regulation Of Canonical Wnt Signaling Pathway Regulation Of Multicellular Organismal Development Positive Regulation Of Angiogenesis Positive Regulation Of Macromolecule Biosynthetic Process Protein Kinase Binding Fructose 1,6-bisphosphate Metabolic Process Regulation Of RNA Metabolic Process	Signal Transduction GDP Binding Regulation Of Cell Junction Assembly Plasma Membrane Small GTPase-mediated Signal Transduction Cell Adhesion Ras Protein Signal Transduction Cell-cell Adhesion Cell Adhesion Molecule Binding Membrane Regulation Of Synapse Assembly Adherens Junction G Protein Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Anchoring Junction Ephrin Receptor Activity Regulation Of Cell Projection Organization Transmembrane-ephrin Receptor Activity Neuron Projection Guidance Axon Guidance Protein Localization To Cell Junction GTPase Activity Plasma Membrane Bounded Cell Projection Organization Cell Junction Organization Neuroligin Family Protein Binding Synapse Regulation Of Cellular Component Organization Cell Junction Assembly Modulation Of Chemical Synaptic Transmission Regulation Of Cell Communication Regulation Of Signaling Postsynaptic Membrane Assembly Intracellular Signaling Cassette Regulation Of Synapse Organization Focal Adhesion Negative Regulation Of Cellular Component Organization Apical Junction Complex Regulation Of Locomotion Zonula Adherens Presynaptic Membrane Cell Projection Organization Postsynaptic Membrane Organization Dendrite Regulation Of Cell Projection Assembly Neuron Projection Development GTP Binding Axon Guidance Receptor Activity Cell Adhesion Mediator Activity Regulation Of Cell Motility Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
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