CTNNA1 and CDH3

Number of citations of the paper that reports this interaction (PubMedID 1924379)
30

Data Source:
HPRD (in vivo)

		CTNNA1	CDH3
Description		catenin alpha 1	cadherin 3
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Zonula Adherens Focal Adhesion Intercalated Disc Actin Cytoskeleton Membrane Catenin Complex Flotillin Complex Lamellipodium Cell Junction Anchoring Junction Plasma Membrane Protein Complex	Cytoplasm Plasma Membrane Adherens Junction Membrane Catenin Complex Cell Junction
	Molecular Function	RNA Binding Structural Molecule Activity Protein Binding Beta-catenin Binding Cytoskeletal Protein Binding Vinculin Binding Identical Protein Binding Protein-containing Complex Binding Gamma-catenin Binding Cadherin Binding Actin Filament Binding	Calcium Ion Binding Beta-catenin Binding Cadherin Binding Metal Ion Binding
	Biological Process	Ovarian Follicle Development Apoptotic Process Cell Adhesion Establishment Or Maintenance Of Cell Polarity Smoothened Signaling Pathway Integrin-mediated Signaling Pathway Neuroblast Proliferation Negative Regulation Of Neuroblast Proliferation Intracellular Protein Localization Male Gonad Development Gap Junction Assembly Cell Migration Axon Regeneration Regulation Of Cell Population Proliferation Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Apical Junction Assembly Response To Estrogen Positive Regulation Of Smoothened Signaling Pathway Cell Motility Cellular Response To Indole-3-methanol Epithelial Cell-cell Adhesion Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell-cell Adhesion Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell Motility Negative Regulation Of Integrin-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Cell Morphogenesis Retina Homeostasis Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Visual Perception Positive Regulation Of Gene Expression Positive Regulation Of Keratinocyte Proliferation Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Hair Cycle Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Keratinization Positive Regulation Of Tyrosinase Activity Adherens Junction Organization Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Melanin Biosynthetic Process Regulation Of Transport Negative Regulation Of Timing Of Catagen Positive Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Positive Regulation Of Melanosome Transport
Pathways		Adherens junctions interactions VEGFR2 mediated vascular permeability Myogenesis Myogenesis RHO GTPases activate IQGAPs Regulation of CDH11 function Regulation of CDH19 Expression and Function Regulation of CDH1 Function Degradation of CDH1 CDH11 homotypic and heterotypic interactions	Adherens junctions interactions
Drugs
Diseases			Hypotrichosis, congenital, with juvenile macular dystrophy Ectodermal dysplasia, ectrodactyly, and macular dystrophy (EEM syndrome)
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) General risk tolerance (MTAG) ( 30643258) Malaria ( 31844061) Schizophrenia ( 25056061)	Cutaneous melanoma or hair colour ( 32341527) Glycated hemoglobin levels ( 28898252) Mean reticulocyte volume ( 32888494) Multiple sclerosis ( 24076602 31604244) Platelet count ( 32888494) Red cell distribution width ( 27863252) Ulcerative colitis ( 28067908)
Interacting Genes		55 interacting genes: ACTN1 AFDN AJUBA AKT1 ALDOB APP ARMC8 BAAT CA9 CCDC180 CDC42 CDH1 CDH15 CDH2 CDH3 CDH5 CSNK2A1 CTBP1 CTNNB1 CTSV DLG1 DYRK1A EIF4ENIF1 F2RL1 FBP1 FBP2 FRAT2 HRAS HSD17B3 HSPA13 JUP LRATD2 MAP2K1 MTNR1A MTNR1B NANS PKD1 PSEN1 RBM26 RNF10 SASH1 SFRP2 SFRP4 SMAD1 SPTAN1 SPTBN1 STX17 TDRD7 TJP1 TJP2 UBE2I VCL ZGPAT ZNF189 ZNF510	3 interacting genes: CTNNA1 CTNNB1 CTNND1
Entrez ID		1495	1001
HPRD ID		00285	00227
Ensembl ID		ENSG00000044115	ENSG00000062038
Uniprot IDs		A0A384MDY0 B4DKT9 B4DU00 G3XAM7 P35221	B4DLF0 P22223
PDB IDs		1H6G 4EHP 4IGG 6UPV 6V2O 6V2P 7UTJ 9BL2 9BL3 9BL4	4OY9 4ZML 4ZMN 4ZMO 4ZMP 4ZMQ 4ZMT 4ZMV 4ZMW 4ZMX 4ZMY 4ZMZ 5JYL 5JYM 6ZTB 6ZTR 7CME 7CMF 8HYI
Enriched GO Terms of Interacting Partners?		Cell-cell Junction Organization Cell Junction Organization Adherens Junction Cadherin Binding Adherens Junction Organization Cell Junction Assembly Cell-cell Junction Assembly Cell Junction Cell-cell Adhesion Catenin Complex Cell-cell Junction Cell-cell Adhesion Mediated By Cadherin Alpha-catenin Binding Anchoring Junction Cell Adhesion Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Fascia Adherens Anatomical Structure Morphogenesis Regulation Of Cell Motility Regulation Of Protein Localization Glutamatergic Synapse Regulation Of Locomotion Beta-catenin Binding Regulation Of Cell Migration Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Component Organization Plasma Membrane Cellular Response To Indole-3-methanol Regulation Of Supramolecular Fiber Organization Cell Development Regulation Of Cell Population Proliferation Response To Indole-3-methanol Cytoplasm Cortical Actin Cytoskeleton Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Wnt Signaling Pathway Positive Regulation Of Gene Expression Regulation Of DNA-templated Transcription Developmental Process Regulation Of RNA Biosynthetic Process Regulation Of Cell Adhesion Negative Regulation Of Signal Transduction Regulation Of Canonical Wnt Signaling Pathway Regulation Of Multicellular Organismal Development Positive Regulation Of Angiogenesis Positive Regulation Of Macromolecule Biosynthetic Process Protein Kinase Binding Fructose 1,6-bisphosphate Metabolic Process Regulation Of RNA Metabolic Process	Catenin Complex Adherens Junction Cell-cell Junction Cell-cell Adhesion Mediated By Cadherin Cadherin Binding Anchoring Junction Cellular Response To Indole-3-methanol Response To Indole-3-methanol Cell-cell Adhesion Regulation Of Blood Vessel Branching Cell-cell Junction Assembly Flotillin Complex Cell-cell Junction Organization Cell Adhesion Cell Junction Cell Migration Cell Migration Involved In Sprouting Angiogenesis Cell Junction Assembly Cell Motility Regulation Of Angiogenesis Blood Vessel Endothelial Cell Migration Cell-cell Adhesion Mediator Activity Regulation Of Vasculature Development Regulation Of Endothelial Cell Differentiation Regulation Of Neuroblast Proliferation Neuroblast Proliferation Intercalated Disc Regulation Of Multicellular Organismal Development Signaling Receptor Binding Adherens Junction Organization Phosphatase Binding Regulation Of Morphogenesis Of A Branching Structure Cell Junction Organization Odontogenesis Of Dentin-containing Tooth Regulation Of Morphogenesis Of An Epithelium Endothelial Cell Migration Cell Periphery Protein Phosphatase Binding Cell Surface Receptor Signaling Pathway Regulation Of Neural Precursor Cell Proliferation Neural Precursor Cell Proliferation Odontogenesis Beta-catenin Binding Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Negative Regulation Of Blood Vessel Branching Negative Regulation Of Cell Population Proliferation Bicellular Tight Junction Transmembrane Transporter Binding Regulation Of Cell Development
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