ANGPTL3 and ITGA5

Number of citations of the paper that reports this interaction (PMID 11877390)
38

Data Source:
HPRD (in vitro)

		ANGPTL3	ITGA5
Gene Name		angiopoietin-like 3	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cell Surface	Ruffle Cytoplasm Plasma Membrane Cell-cell Junction Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Ruffle Membrane Synapse Alphav-beta3 Integrin-vitronectin Complex
	Molecular Function	Enzyme Inhibitor Activity Phospholipase Inhibitor Activity Integrin Binding Growth Factor Activity	Epidermal Growth Factor Receptor Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Protein Binding Vascular Endothelial Growth Factor Receptor 2 Binding Metal Ion Binding
	Biological Process	Glycerol Metabolic Process Fatty Acid Metabolic Process Phospholipid Metabolic Process Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Cholesterol Metabolic Process Phospholipid Catabolic Process Negative Regulation Of Phospholipase Activity Lipid Storage Positive Regulation Of Cell Migration Cholesterol Homeostasis Positive Regulation Of Angiogenesis Artery Morphogenesis Positive Regulation Of Lipid Catabolic Process Negative Regulation Of Lipoprotein Lipase Activity Lipid Homeostasis Acylglycerol Homeostasis Phospholipid Homeostasis Triglyceride Homeostasis	Angiogenesis Cell-substrate Junction Assembly Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Memory Positive Regulation Of Cell-substrate Adhesion Viral Process Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Wound Healing, Spreading Of Epidermal Cells Endodermal Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Negative Regulation Of Anoikis
Pathways			Signal transduction by L1 Axon guidance Elastic fibre formation Fibronectin matrix formation L1CAM interactions Integrin cell surface interactions Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Cholesterol, total ( 20686565) LDL cholesterol ( 20686565) Lipid metabolism phenotypes ( 22286219 19936222) Metabolite levels ( 22916037) Triglycerides ( 18193043 18193044 20864672 19060906 20139978 20686565)
Protein-Protein Interactions		4 interactors: ITGA5 ITGAV ITGB3 UBC	24 interactors: ANGPT1 ANGPTL3 ARHGAP5 AUP1 CD9 COL18A1 COL1A1 EGFR ERBB2 FGFR2 FLT4 FN1 GIPC1 GRK6 ITGB1 ITGB3 ITGB5 L1CAM NISCH PECAM1 RABIF SPP1 STAMBP TNC
Entrez ID		27329	3678
HPRD ID		10381	00627
Ensembl ID		ENSG00000132855	ENSG00000161638
Uniprot IDs		A0JLS0 B1ALJ0 Q9Y5C1	P08648
PDB IDs			3VI3 3VI4
Enriched GO Terms of Interacting Partners?		Heterotypic Cell-cell Adhesion Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Receptor Biosynthetic Process Apolipoprotein A-I-mediated Signaling Pathway Viral Process Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Integrin-mediated Signaling Pathway Formation Of Primary Germ Layer Negative Regulation Of Lipoprotein Metabolic Process Regulation Of Lipoprotein Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Gastrulation Viral Life Cycle Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Receptor Biosynthetic Process Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Leukocyte Migration Negative Regulation Of Lipid Storage Negative Chemotaxis Negative Regulation Of Lipid Transport Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Migration Angiogenesis Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Endodermal Cell Differentiation Extracellular Matrix Organization Extracellular Structure Organization Viral Entry Into Host Cell Axon Guidance Entry Into Host Cell Substrate Adhesion-dependent Cell Spreading Regulation Of Macrophage Derived Foam Cell Differentiation Blood Coagulation Blood Vessel Morphogenesis Hemostasis Cell-substrate Junction Assembly Endoderm Formation Regulation Of Lipid Storage Blood Vessel Development Single Organismal Cell-cell Adhesion Axonogenesis Vasculature Development Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Migration Wound Healing	Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cell Adhesion Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cell Migration Regulation Of Cell Motility Cardiovascular System Development Regulation Of Locomotion Regulation Of Cellular Component Movement Blood Vessel Development Vasculature Development Leukocyte Migration Response To Stimulus Positive Regulation Of Cell Proliferation Wound Healing Regulation Of Cell Proliferation Anatomical Structure Morphogenesis Response To Wounding Cell-substrate Adhesion Cell Migration Response To Growth Factor Movement Of Cell Or Subcellular Component Multicellular Organismal Development Blood Vessel Morphogenesis Blood Coagulation Cell Motility Hemostasis System Development Anatomical Structure Development Cellular Response To Stimulus Locomotion Cell Communication Positive Regulation Of Signal Transduction Regulation Of Signaling Cell-matrix Adhesion Angiogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of Signal Transduction Developmental Process Response To Vitamin Response To Nutrient Regulation Of Body Fluid Levels Signaling Cell Activation Regulation Of Cellular Process Formation Of Primary Germ Layer Signal Transduction
Tagcloud ?		adipokine adipokines adiponectin bmp7 caucasian chemerin clusters ctrp3 dlk1 dll1 glycemia glypican gpx3 hierarchical homa hyperglycemia nampt obesity omentin progranulin rbp4 recognize resistin sfrp5 strongest t2d unbiased vaspin
Tagcloud (Difference) ?		adipokine adipokines adiponectin bmp7 caucasian chemerin clusters ctrp3 dlk1 dll1 glycemia glypican gpx3 hierarchical homa hyperglycemia nampt obesity omentin progranulin rbp4 recognize resistin sfrp5 strongest t2d unbiased vaspin
Tagcloud (Intersection) ?