ANGPTL3

Description		angiopoietin like 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Early Endosome Golgi Apparatus Cell Surface Lamellipodium Extracellular Matrix Cell Projection
	Molecular Function	Enzyme Inhibitor Activity Phospholipase Inhibitor Activity Integrin Binding Growth Factor Activity Heparin Binding Lipase Binding Lipase Inhibitor Activity
	Biological Process	Angiogenesis Glycerol Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Phospholipid Metabolic Process Cell Adhesion Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Cholesterol Metabolic Process Phospholipid Catabolic Process Response To Hormone Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Lipid Storage Positive Regulation Of Cell Migration Cholesterol Homeostasis Positive Regulation Of Angiogenesis Artery Morphogenesis Positive Regulation Of Lipid Catabolic Process Lipid Homeostasis Acylglycerol Homeostasis Phospholipid Homeostasis Triglyceride Homeostasis Regulation Of Chylomicron Remodeling
Pathways		Assembly of active LPL and LIPC lipase complexes NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
Drugs		Evinacumab
Diseases
GWAS		Blood protein levels ( 30072576) Cholesterol, total ( 26582766 20686565 25961943 24097068) Crohn's disease ( 28067908) LDL cholesterol ( 25961943 20686565 24097068) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219 19936222) Metabolite levels ( 22916037) Regular attendance at a gym or sports club ( 29970889) Total cholesterol levels ( 28334899) Total triglycerides levels ( 26690388) Triglyceride levels ( 28334899 29615537) Triglycerides ( 24097068 26582766 25961943 18193043 20864672 20686565 20139978 19060906 18193044)
Interacting Genes		4 interacting genes: ITGA5 ITGAV ITGB3 UBC
Entrez ID		27329
HPRD ID		10381
Ensembl ID		ENSG00000132855
Uniprot IDs		Q9Y5C1
PDB IDs		6EUA
Enriched GO Terms of Interacting Partners?		Wound Healing, Spreading Of Epidermal Cells Wound Healing, Spreading Of Cells Integrin Complex Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Integrin Alphav-beta3 Complex Alphav-beta3 Integrin-vitronectin Complex Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-HMGB1 Complex Alphav-beta3 Integrin-IGF-1-IGF1R Complex Virus Receptor Activity Apolipoprotein A-I-mediated Signaling Pathway C-X3-C Chemokine Binding Negative Regulation Of Lipoprotein Metabolic Process Neuregulin Binding Ruffle Membrane Integrin-mediated Signaling Pathway Cell-matrix Adhesion Symbiont Entry Into Host Cell Vascular Endothelial Growth Factor Receptor 2 Binding Integrin Binding Biological Process Involved In Interaction With Host Cell-substrate Adhesion Negative Regulation Of Low-density Lipoprotein Particle Clearance Insulin-like Growth Factor I Binding Positive Regulation Of Osteoblast Proliferation Negative Regulation Of Macrophage Derived Foam Cell Differentiation Platelet-derived Growth Factor Receptor Binding Regulation Of Lipoprotein Metabolic Process Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Lipoprotein Particle Clearance Filopodium Membrane Regulation Of Low-density Lipoprotein Particle Clearance Negative Regulation Of Lipid Storage Fibroblast Growth Factor Binding Lamellipodium Membrane Apoptotic Cell Clearance Microvillus Membrane Fibronectin Binding Regulation Of Osteoblast Proliferation Extracellular Matrix Binding Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Angiogenesis Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Endodermal Cell Differentiation Negative Regulation Of Lipid Transport Cell-substrate Junction Assembly Cell-substrate Junction Organization
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