ANGPTL3

Gene Name		angiopoietin-like 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cell Surface
	Molecular Function	Enzyme Inhibitor Activity Phospholipase Inhibitor Activity Integrin Binding Growth Factor Activity
	Biological Process	Glycerol Metabolic Process Fatty Acid Metabolic Process Phospholipid Metabolic Process Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Cholesterol Metabolic Process Phospholipid Catabolic Process Negative Regulation Of Phospholipase Activity Lipid Storage Positive Regulation Of Cell Migration Cholesterol Homeostasis Positive Regulation Of Angiogenesis Artery Morphogenesis Positive Regulation Of Lipid Catabolic Process Negative Regulation Of Lipoprotein Lipase Activity Lipid Homeostasis Acylglycerol Homeostasis Phospholipid Homeostasis Triglyceride Homeostasis
Pathways
Drugs
Diseases
GWAS		Cholesterol, total ( 20686565) LDL cholesterol ( 20686565) Lipid metabolism phenotypes ( 22286219 19936222) Metabolite levels ( 22916037) Triglycerides ( 18193043 18193044 20864672 19060906 20139978 20686565)
Protein-protein Interactions		4 interactors: ITGA5 ITGAV ITGB3 UBC
Entrez ID		27329
HPRD ID		10381
Ensembl ID		ENSG00000132855
Uniprot IDs		A0JLS0 B1ALJ0 Q9Y5C1
PDB IDs
Enriched GO Terms of Interacting Partners?		Heterotypic Cell-cell Adhesion Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Receptor Biosynthetic Process Apolipoprotein A-I-mediated Signaling Pathway Viral Process Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Integrin-mediated Signaling Pathway Formation Of Primary Germ Layer Negative Regulation Of Lipoprotein Metabolic Process Regulation Of Lipoprotein Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Gastrulation Viral Life Cycle Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Receptor Biosynthetic Process Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Leukocyte Migration Negative Regulation Of Lipid Storage Negative Chemotaxis Negative Regulation Of Lipid Transport Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Migration Angiogenesis Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Endodermal Cell Differentiation Extracellular Matrix Organization Extracellular Structure Organization Viral Entry Into Host Cell Axon Guidance Entry Into Host Cell Substrate Adhesion-dependent Cell Spreading Regulation Of Macrophage Derived Foam Cell Differentiation Blood Coagulation Blood Vessel Morphogenesis Hemostasis Cell-substrate Junction Assembly Endoderm Formation Regulation Of Lipid Storage Blood Vessel Development Single Organismal Cell-cell Adhesion Axonogenesis Vasculature Development Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Migration Wound Healing
Tagcloud ?		adipokine adipokines adiponectin bmp7 caucasian chemerin clusters ctrp3 dlk1 dll1 glycemia glypican gpx3 hierarchical homa hyperglycemia nampt obesity omentin progranulin rbp4 recognize resistin sfrp5 strongest t2d unbiased vaspin