ANGPTL3 and ITGAV

Number of citations of the paper that reports this interaction (PMID 11877390)
38

Data Source:
HPRD (in vivo)

		ANGPTL3	ITGAV
Gene Name		angiopoietin-like 3	integrin, alpha V
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cell Surface	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Lamellipodium Membrane Filopodium Membrane Microvillus Membrane Ruffle Membrane Integrin Alphav-beta3 Complex Integrin Alphav-beta5 Complex Integrin Alphav-beta8 Complex Alphav-beta3 Integrin-IGF-1-IGF1R Complex Phagocytic Vesicle Extracellular Vesicular Exosome
	Molecular Function	Enzyme Inhibitor Activity Phospholipase Inhibitor Activity Integrin Binding Growth Factor Activity	Virus Receptor Activity Opsonin Binding Fibronectin Binding Protease Binding Protein Kinase C Binding Voltage-gated Calcium Channel Activity Protein Binding Insulin-like Growth Factor I Binding Metal Ion Binding Transforming Growth Factor Beta Binding Extracellular Matrix Binding Extracellular Matrix Protein Binding
	Biological Process	Glycerol Metabolic Process Fatty Acid Metabolic Process Phospholipid Metabolic Process Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Cholesterol Metabolic Process Phospholipid Catabolic Process Negative Regulation Of Phospholipase Activity Lipid Storage Positive Regulation Of Cell Migration Cholesterol Homeostasis Positive Regulation Of Angiogenesis Artery Morphogenesis Positive Regulation Of Lipid Catabolic Process Negative Regulation Of Lipoprotein Lipase Activity Lipid Homeostasis Acylglycerol Homeostasis Phospholipid Homeostasis Triglyceride Homeostasis	Angiogenesis Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Positive Regulation Of Cell Proliferation Response To Virus Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Cell Growth Cell Migration Extracellular Matrix Organization Positive Regulation Of Cell Migration Cell-substrate Adhesion Negative Regulation Of Lipid Transport Positive Regulation Of Osteoblast Proliferation Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Apolipoprotein A-I-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Apoptotic Cell Clearance Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Cell Adhesion Viral Entry Into Host Cell Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Lipoprotein Metabolic Process Regulation Of Phagocytosis Leukocyte Migration Negative Chemotaxis Entry Of Symbiont Into Host Cell By Promotion Of Host Phagocytosis ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Apoptotic Cell Clearance Negative Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Signal transduction by L1 Axon guidance Elastic fibre formation L1CAM interactions Non-integrin membrane-ECM interactions VEGFA-VEGFR2 Pathway Cell surface interactions at the vascular wall PECAM1 interactions Molecules associated with elastic fibres Syndecan interactions Laminin interactions Signaling by VEGF ECM proteoglycans Integrin cell surface interactions Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System
Drugs
Diseases
GWAS		Cholesterol, total ( 20686565) LDL cholesterol ( 20686565) Lipid metabolism phenotypes ( 22286219 19936222) Metabolite levels ( 22916037) Triglycerides ( 18193043 18193044 20864672 19060906 20139978 20686565)
Protein-Protein Interactions		4 interactors: ITGA5 ITGAV ITGB3 UBC	28 interactors: ADAM9 ANGPTL3 AUP1 AZGP1 CALR CD47 CYR61 EDIL3 F2R ICAM4 ITGB1 ITGB3 ITGB5 ITGB6 ITGB8 L1CAM MMP14 MMP2 NID1 NOV P2RY2 PAK4 PDGFRA PLP1 PTK2 SPP1 TGFB1 THY1
Entrez ID		27329	3685
HPRD ID		10381	01903
Ensembl ID		ENSG00000132855	ENSG00000138448
Uniprot IDs		A0JLS0 B1ALJ0 Q9Y5C1	B7ZLX0 P06756
PDB IDs			1JV2 1L5G 1M1X 1U8C 3IJE 4G1E 4G1M
Enriched GO Terms of Interacting Partners?		Heterotypic Cell-cell Adhesion Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Receptor Biosynthetic Process Apolipoprotein A-I-mediated Signaling Pathway Viral Process Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Integrin-mediated Signaling Pathway Formation Of Primary Germ Layer Negative Regulation Of Lipoprotein Metabolic Process Regulation Of Lipoprotein Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Gastrulation Viral Life Cycle Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Receptor Biosynthetic Process Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Leukocyte Migration Negative Regulation Of Lipid Storage Negative Chemotaxis Negative Regulation Of Lipid Transport Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Migration Angiogenesis Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Endodermal Cell Differentiation Extracellular Matrix Organization Extracellular Structure Organization Viral Entry Into Host Cell Axon Guidance Entry Into Host Cell Substrate Adhesion-dependent Cell Spreading Regulation Of Macrophage Derived Foam Cell Differentiation Blood Coagulation Blood Vessel Morphogenesis Hemostasis Cell-substrate Junction Assembly Endoderm Formation Regulation Of Lipid Storage Blood Vessel Development Single Organismal Cell-cell Adhesion Axonogenesis Vasculature Development Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Migration Wound Healing	Extracellular Matrix Organization Extracellular Structure Organization Cell Adhesion Integrin-mediated Signaling Pathway Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Cell Adhesion Positive Regulation Of Cell Motility Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Cell-matrix Adhesion Regulation Of Locomotion Regulation Of Cellular Component Movement Cell-substrate Adhesion Positive Regulation Of Cell Adhesion Locomotion Regulation Of Cell-substrate Adhesion Cardiovascular System Development Blood Vessel Development Response To External Stimulus Vasculature Development Single Organismal Cell-cell Adhesion Multicellular Organismal Development Cell Surface Receptor Signaling Pathway Developmental Process Blood Vessel Morphogenesis Cell Migration Tissue Development Cell Motility Angiogenesis Movement Of Cell Or Subcellular Component Positive Regulation Of Cell-substrate Adhesion Anatomical Structure Development Signaling Cell Communication Response To Stimulus Positive Regulation Of Cell Proliferation Signal Transduction Chemotaxis Wound Healing Organ Development Blood Coagulation Hemostasis System Development Cell-cell Adhesion Mediated By Integrin Single Organism Reproductive Process Response To Wounding Positive Regulation Of Kinase Activity Anatomical Structure Morphogenesis
Tagcloud ?		adipokine adipokines adiponectin bmp7 caucasian chemerin clusters ctrp3 dlk1 dll1 glycemia glypican gpx3 hierarchical homa hyperglycemia nampt obesity omentin progranulin rbp4 recognize resistin sfrp5 strongest t2d unbiased vaspin	bcl colorectal corresponding crc dissemination event extracellular ihc immunohistochemistry invasion ki matrix metastasis neoplastic overexpression perineural polymerase progression quantitative real regard resection sparc spread thbs1 underwent validation vcam vegf
Tagcloud (Difference) ?		adipokine adipokines adiponectin bmp7 caucasian chemerin clusters ctrp3 dlk1 dll1 glycemia glypican gpx3 hierarchical homa hyperglycemia nampt obesity omentin progranulin rbp4 recognize resistin sfrp5 strongest t2d unbiased vaspin	bcl colorectal corresponding crc dissemination event extracellular ihc immunohistochemistry invasion ki matrix metastasis neoplastic overexpression perineural polymerase progression quantitative real regard resection sparc spread thbs1 underwent validation vcam vegf
Tagcloud (Intersection) ?