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FGFR2 and ITGA5
Number of citations of the paper that reports this interaction (PMID
15728256
)
18
Data Source:
HPRD
(in vitro)
FGFR2
ITGA5
Gene Name
fibroblast growth factor receptor 2
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Image
Gene Ontology Annotations
Cellular Component
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Cortex
Cell Surface
Membrane
Integral Component Of Membrane
Cytoplasmic Membrane-bounded Vesicle
Extracellular Matrix
Intracellular Membrane-bounded Organelle
Excitatory Synapse
Ruffle
Cytoplasm
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Integrin Complex
External Side Of Plasma Membrane
Cell Surface
Ruffle Membrane
Synapse
Alphav-beta3 Integrin-vitronectin Complex
Molecular Function
Protein Tyrosine Kinase Activity
Fibroblast Growth Factor-activated Receptor Activity
Protein Binding
ATP Binding
Heparin Binding
Fibroblast Growth Factor Binding
Protein Homodimerization Activity
Epidermal Growth Factor Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Integrin Binding
Protein Binding
Vascular Endothelial Growth Factor Receptor 2 Binding
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Angiogenesis
Ureteric Bud Development
In Utero Embryonic Development
Epithelial To Mesenchymal Transition
Positive Regulation Of Mesenchymal Cell Proliferation
Outflow Tract Septum Morphogenesis
Membranous Septum Morphogenesis
Apoptotic Process
Epidermal Growth Factor Receptor Signaling Pathway
Cell-cell Signaling
Axonogenesis
Neuromuscular Junction Development
Positive Regulation Of Cell Proliferation
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Smoothened Signaling Pathway
Post-embryonic Development
Embryonic Pattern Specification
Organ Morphogenesis
Regulation Of Cell Fate Commitment
Positive Regulation Of Phospholipase Activity
Morphogenesis Of Embryonic Epithelium
Peptidyl-tyrosine Phosphorylation
Orbitofrontal Cortex Development
Ventricular Zone Neuroblast Division
Pyramidal Neuron Development
Gland Morphogenesis
Positive Regulation Of Wnt Signaling Pathway
Bone Mineralization
Lung Development
Epithelial Cell Differentiation
Midbrain Development
Otic Vesicle Formation
Hair Follicle Morphogenesis
Lacrimal Gland Development
Regulation Of Osteoblast Proliferation
Multicellular Organism Growth
Organ Growth
Fibroblast Growth Factor Receptor Signaling Pathway Involved In Negative Regulation Of Apoptotic Process In Bone Marrow
Fibroblast Growth Factor Receptor Signaling Pathway Involved In Hemopoiesis
Fibroblast Growth Factor Receptor Signaling Pathway Involved In Positive Regulation Of Cell Proliferation In Bone Marrow
Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development
Fc-epsilon Receptor Signaling Pathway
Regulation Of Multicellular Organism Growth
Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Inner Ear Morphogenesis
Odontogenesis
Positive Regulation Of MAPK Cascade
Innate Immune Response
Cell Fate Commitment
Regulation Of Osteoblast Differentiation
Positive Regulation Of Cell Cycle
Negative Regulation Of Mitotic Nuclear Division
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Protein Autophosphorylation
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Lung Alveolus Development
Mesodermal Cell Differentiation
Synaptic Vesicle Transport
Embryonic Digestive Tract Morphogenesis
Embryonic Organ Morphogenesis
Digestive Tract Development
Embryonic Organ Development
Reproductive Structure Development
Positive Regulation Of Smooth Muscle Cell Proliferation
Embryonic Cranial Skeleton Morphogenesis
Skeletal System Morphogenesis
Epidermis Morphogenesis
Branching Morphogenesis Of A Nerve
Mesenchymal Cell Differentiation
Positive Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Epithelial Cell Proliferation
Regulation Of Smooth Muscle Cell Differentiation
Positive Regulation Of Cell Division
Ventricular Cardiac Muscle Tissue Morphogenesis
Positive Regulation Of Cardiac Muscle Cell Proliferation
Limb Bud Formation
Bone Development
Bone Morphogenesis
Coronal Suture Morphogenesis
Branching Involved In Prostate Gland Morphogenesis
Branching Involved In Salivary Gland Morphogenesis
Bud Elongation Involved In Lung Branching
Lung Lobe Morphogenesis
Lung-associated Mesenchyme Development
Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
Prostate Gland Morphogenesis
Prostate Epithelial Cord Elongation
Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis
Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development
Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification
Lateral Sprouting From An Epithelium
Mammary Gland Bud Formation
Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis
Branch Elongation Involved In Salivary Gland Morphogenesis
Branching Involved In Labyrinthine Layer Morphogenesis
Regulation Of Branching Involved In Prostate Gland Morphogenesis
Regulation Of Morphogenesis Of A Branching Structure
Mesenchymal Cell Differentiation Involved In Lung Development
Mesenchymal Cell Proliferation Involved In Lung Development
Endodermal Digestive Tract Morphogenesis
Lens Fiber Cell Development
Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Canonical Wnt Signaling Pathway
Angiogenesis
Cell-substrate Junction Assembly
Cell Adhesion
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Leukocyte Cell-cell Adhesion
Integrin-mediated Signaling Pathway
Axon Guidance
Blood Coagulation
Memory
Positive Regulation Of Cell-substrate Adhesion
Viral Process
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cell-substrate Adhesion
Cell-cell Adhesion Mediated By Integrin
Heterotypic Cell-cell Adhesion
Wound Healing, Spreading Of Epidermal Cells
Endodermal Cell Differentiation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Leukocyte Migration
Negative Regulation Of Anoikis
Pathways
Signaling by FGFR2 amplification mutants
Signaling by FGFR2 mutants
Signaling by FGFR in disease
Signaling by FGFR mutants
Activated point mutants of FGFR2
Signal transduction by L1
Axon guidance
Elastic fibre formation
Fibronectin matrix formation
L1CAM interactions
Integrin cell surface interactions
Cell surface interactions at the vascular wall
Drugs
Palifermin
Thalidomide
SU4984
4-[4-(1-Amino-1-Methylethyl)Phenyl]-5-Chloro-N-[4-(2-Morpholin-4-Ylethyl)Phenyl]Pyrimidin-2-Amine
Regorafenib
Ponatinib
Diseases
GWAS
Breast cancer (
21263130
20872241
23354978
17529967
23535729
17529973
22951594
20453838
19330030
21060860
)
Prostate-specific antigen levels (
21160077
)
Protein-Protein Interactions
21 interactors:
APP
CACNA1D
EPHA4
FGF1
FGF10
FGF17
FGF18
FGF23
FGF3
FGF4
FGF5
FGF6
FGF7
FGF8
FGF9
ITGA5
NEDD4
PAK4
PLCG1
PPM1A
PTK2B
24 interactors:
ANGPT1
ANGPTL3
ARHGAP5
AUP1
CD9
COL18A1
COL1A1
EGFR
ERBB2
FGFR2
FLT4
FN1
GIPC1
GRK6
ITGB1
ITGB3
ITGB5
L1CAM
NISCH
PECAM1
RABIF
SPP1
STAMBP
TNC
Entrez ID
2263
3678
HPRD ID
01492
00627
Ensembl ID
ENSG00000066468
ENSG00000161638
Uniprot IDs
D2CGD1
P21802
P08648
PDB IDs
1DJS
1E0O
1EV2
1GJO
1II4
1IIL
1NUN
1OEC
1WVZ
2FDB
2PSQ
2PVF
2PVY
2PWL
2PY3
2PZ5
2PZP
2PZR
2Q0B
3B2T
3CAF
3CLY
3CU1
3DAR
3EUU
3OJ2
3OJM
3RI1
4J95
4J96
4J97
4J98
4J99
3VI3
3VI4
Enriched GO Terms of Interacting Partners
?
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Phosphatidylinositol-mediated Signaling
Neurotrophin TRK Receptor Signaling Pathway
Cellular Response To Insulin Stimulus
Neurotrophin Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Fc Receptor Signaling Pathway
Response To Insulin
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Peptide
Enzyme Linked Receptor Protein Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Innate Immune Response
Response To Peptide Hormone
Immune Response-regulating Signaling Pathway
Cellular Response To Organonitrogen Compound
Response To Peptide
Cell Surface Receptor Signaling Pathway
Immune Response
Cellular Response To Hormone Stimulus
Response To Organonitrogen Compound
Response To Hormone
Defense Response
Immune System Process
Signal Transduction
Cellular Response To Organic Substance
Regulation Of Immune Response
Cell-cell Signaling
Signaling
Positive Regulation Of Cell Division
Cell Communication
Regulation Of Immune System Process
Positive Regulation Of Cell Proliferation
Intracellular Signal Transduction
Anatomical Structure Morphogenesis
Regulation Of Cellular Response To Growth Factor Stimulus
Cellular Response To Stimulus
Response To Organic Substance
Positive Regulation Of Intracellular Signal Transduction
Cell Differentiation
Response To Stress
System Development
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Cell Adhesion
Positive Regulation Of Cellular Component Movement
Positive Regulation Of Locomotion
Extracellular Matrix Organization
Extracellular Structure Organization
Regulation Of Cell Migration
Regulation Of Cell Motility
Cardiovascular System Development
Regulation Of Locomotion
Regulation Of Cellular Component Movement
Blood Vessel Development
Vasculature Development
Leukocyte Migration
Response To Stimulus
Positive Regulation Of Cell Proliferation
Wound Healing
Regulation Of Cell Proliferation
Anatomical Structure Morphogenesis
Response To Wounding
Cell-substrate Adhesion
Cell Migration
Response To Growth Factor
Movement Of Cell Or Subcellular Component
Multicellular Organismal Development
Blood Vessel Morphogenesis
Blood Coagulation
Cell Motility
Hemostasis
System Development
Anatomical Structure Development
Cellular Response To Stimulus
Locomotion
Cell Communication
Positive Regulation Of Signal Transduction
Regulation Of Signaling
Cell-matrix Adhesion
Angiogenesis
Anatomical Structure Formation Involved In Morphogenesis
Regulation Of Signal Transduction
Developmental Process
Response To Vitamin
Response To Nutrient
Regulation Of Body Fluid Levels
Signaling
Cell Activation
Regulation Of Cellular Process
Formation Of Primary Germ Layer
Signal Transduction
Tagcloud
?
altogether
basic
bfgf
bfgf1
bfgf55
bfgf75
bk1
bk2
chimera
chimeras
confer
fgfr1
fgfr4
fibroblast
gfg
interacted
kb1
kb2
keratinocyte
kgf
kgf111
kgf31
kgf91
kgfr
neutralized
neutralizing
reciprocal
structurally
Tagcloud (Difference)
?
altogether
basic
bfgf
bfgf1
bfgf55
bfgf75
bk1
bk2
chimera
chimeras
confer
fgfr1
fgfr4
fibroblast
gfg
interacted
kb1
kb2
keratinocyte
kgf
kgf111
kgf31
kgf91
kgfr
neutralized
neutralizing
reciprocal
structurally
Tagcloud (Intersection)
?