FGFR2 and EPHA4

Number of citations of the paper that reports this interaction (PMID 16365308)
21

Data Source:
HPRD (two hybrid, in vivo)

		FGFR2	EPHA4
Gene Name		fibroblast growth factor receptor 2	EPH receptor A4
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Cell Surface Membrane Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Extracellular Matrix Intracellular Membrane-bounded Organelle Excitatory Synapse	Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Postsynaptic Density Cell Junction Filopodium Axon Dendrite Neuromuscular Junction Early Endosome Membrane Dendritic Spine Perikaryon Axon Terminus Axonal Growth Cone Postsynaptic Membrane
	Molecular Function	Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Heparin Binding Fibroblast Growth Factor Binding Protein Homodimerization Activity	Protein Kinase Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding PH Domain Binding Identical Protein Binding Ephrin Receptor Binding DH Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Ureteric Bud Development In Utero Embryonic Development Epithelial To Mesenchymal Transition Positive Regulation Of Mesenchymal Cell Proliferation Outflow Tract Septum Morphogenesis Membranous Septum Morphogenesis Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Axonogenesis Neuromuscular Junction Development Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Smoothened Signaling Pathway Post-embryonic Development Embryonic Pattern Specification Organ Morphogenesis Regulation Of Cell Fate Commitment Positive Regulation Of Phospholipase Activity Morphogenesis Of Embryonic Epithelium Peptidyl-tyrosine Phosphorylation Orbitofrontal Cortex Development Ventricular Zone Neuroblast Division Pyramidal Neuron Development Gland Morphogenesis Positive Regulation Of Wnt Signaling Pathway Bone Mineralization Lung Development Epithelial Cell Differentiation Midbrain Development Otic Vesicle Formation Hair Follicle Morphogenesis Lacrimal Gland Development Regulation Of Osteoblast Proliferation Multicellular Organism Growth Organ Growth Fibroblast Growth Factor Receptor Signaling Pathway Involved In Negative Regulation Of Apoptotic Process In Bone Marrow Fibroblast Growth Factor Receptor Signaling Pathway Involved In Hemopoiesis Fibroblast Growth Factor Receptor Signaling Pathway Involved In Positive Regulation Of Cell Proliferation In Bone Marrow Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Fc-epsilon Receptor Signaling Pathway Regulation Of Multicellular Organism Growth Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Inner Ear Morphogenesis Odontogenesis Positive Regulation Of MAPK Cascade Innate Immune Response Cell Fate Commitment Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Lung Alveolus Development Mesodermal Cell Differentiation Synaptic Vesicle Transport Embryonic Digestive Tract Morphogenesis Embryonic Organ Morphogenesis Digestive Tract Development Embryonic Organ Development Reproductive Structure Development Positive Regulation Of Smooth Muscle Cell Proliferation Embryonic Cranial Skeleton Morphogenesis Skeletal System Morphogenesis Epidermis Morphogenesis Branching Morphogenesis Of A Nerve Mesenchymal Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Cell Division Ventricular Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Cardiac Muscle Cell Proliferation Limb Bud Formation Bone Development Bone Morphogenesis Coronal Suture Morphogenesis Branching Involved In Prostate Gland Morphogenesis Branching Involved In Salivary Gland Morphogenesis Bud Elongation Involved In Lung Branching Lung Lobe Morphogenesis Lung-associated Mesenchyme Development Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Prostate Gland Morphogenesis Prostate Epithelial Cord Elongation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification Lateral Sprouting From An Epithelium Mammary Gland Bud Formation Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Branch Elongation Involved In Salivary Gland Morphogenesis Branching Involved In Labyrinthine Layer Morphogenesis Regulation Of Branching Involved In Prostate Gland Morphogenesis Regulation Of Morphogenesis Of A Branching Structure Mesenchymal Cell Differentiation Involved In Lung Development Mesenchymal Cell Proliferation Involved In Lung Development Endodermal Digestive Tract Morphogenesis Lens Fiber Cell Development Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Canonical Wnt Signaling Pathway	Cell Adhesion Axon Guidance Adult Walking Behavior Motor Neuron Axon Guidance Glial Cell Migration Peptidyl-tyrosine Phosphorylation Corticospinal Tract Morphogenesis Regulation Of Rac GTPase Activity Regulation Of Rap GTPase Activity Positive Regulation Of JUN Kinase Activity Protein Autophosphorylation Ephrin Receptor Signaling Pathway Negative Regulation Of Axon Regeneration Regulation Of Astrocyte Differentiation Regulation Of Axonogenesis Positive Regulation Of Dendrite Morphogenesis Regulation Of Dendritic Spine Morphogenesis Fasciculation Of Sensory Neuron Axon Fasciculation Of Motor Neuron Axon Positive Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity
Pathways		Signaling by FGFR2 amplification mutants Signaling by FGFR2 mutants Signaling by FGFR in disease Signaling by FGFR mutants Activated point mutants of FGFR2	EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs		Palifermin Thalidomide SU4984 4-[4-(1-Amino-1-Methylethyl)Phenyl]-5-Chloro-N-[4-(2-Morpholin-4-Ylethyl)Phenyl]Pyrimidin-2-Amine Regorafenib Ponatinib
Diseases
GWAS		Breast cancer ( 21263130 20872241 23354978 17529967 23535729 17529973 22951594 20453838 19330030 21060860) Prostate-specific antigen levels ( 21160077)	Brain imaging ( 20100581) Paclitaxel-induced neuropathy ( 23776197)
Protein-Protein Interactions		21 interactors: APP CACNA1D EPHA4 FGF1 FGF10 FGF17 FGF18 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 ITGA5 NEDD4 PAK4 PLCG1 PPM1A PTK2B	15 interactors: ARHGEF15 EFNA1 EFNA3 EFNA4 EFNA5 EFNB2 EFNB3 FGFR1 FGFR2 FGFR3 FGFR4 FYN IKBKG NGEF SRC
Entrez ID		2263	2043
HPRD ID		01492	03719
Ensembl ID		ENSG00000066468	ENSG00000116106
Uniprot IDs		D2CGD1 P21802	E9PG71 P54764 Q58F15
PDB IDs		1DJS 1E0O 1EV2 1GJO 1II4 1IIL 1NUN 1OEC 1WVZ 2FDB 2PSQ 2PVF 2PVY 2PWL 2PY3 2PZ5 2PZP 2PZR 2Q0B 3B2T 3CAF 3CLY 3CU1 3DAR 3EUU 3OJ2 3OJM 3RI1 4J95 4J96 4J97 4J98 4J99	2LW8 2WO1 2WO2 2WO3 3CKH 3GXU 4BK4 4BK5 4BKA 4BKF
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Phosphatidylinositol-mediated Signaling Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Response To Insulin Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Innate Immune Response Response To Peptide Hormone Immune Response-regulating Signaling Pathway Cellular Response To Organonitrogen Compound Response To Peptide Cell Surface Receptor Signaling Pathway Immune Response Cellular Response To Hormone Stimulus Response To Organonitrogen Compound Response To Hormone Defense Response Immune System Process Signal Transduction Cellular Response To Organic Substance Regulation Of Immune Response Cell-cell Signaling Signaling Positive Regulation Of Cell Division Cell Communication Regulation Of Immune System Process Positive Regulation Of Cell Proliferation Intracellular Signal Transduction Anatomical Structure Morphogenesis Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Stimulus Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Cell Differentiation Response To Stress System Development	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Signaling Pathway Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Enzyme Linked Receptor Protein Signaling Pathway Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Axon Guidance Neuron Development Peptidyl-tyrosine Phosphorylation Cell Morphogenesis Neuron Differentiation Cell Projection Organization Chemotaxis Generation Of Neurons Neurogenesis Cell Surface Receptor Signaling Pathway Locomotion Anatomical Structure Morphogenesis Cell Development Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Movement Of Cell Or Subcellular Component Fc Receptor Signaling Pathway Nervous System Development Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction System Development Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To External Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Cell-cell Signaling Response To Fibroblast Growth Factor Peptidyl-amino Acid Modification Cell Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Autophosphorylation Multicellular Organismal Development Anatomical Structure Development Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Immune Response-regulating Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Signal Transduction Positive Regulation Of Phosphorylation
Tagcloud ?		altogether basic bfgf bfgf1 bfgf55 bfgf75 bk1 bk2 chimera chimeras confer fgfr1 fgfr4 fibroblast gfg interacted kb1 kb2 keratinocyte kgf kgf111 kgf31 kgf91 kgfr neutralized neutralizing reciprocal structurally	abl adaptor aml1 amongst arising betapdgf chimeric coding dimerization elicits ets folding gtpases hetero homo homodimer homophilic module oligomerize oncogenic property reveals sam scaffolding shared sterile tel threonine
Tagcloud (Difference) ?		altogether basic bfgf bfgf1 bfgf55 bfgf75 bk1 bk2 chimera chimeras confer fgfr1 fgfr4 fibroblast gfg interacted kb1 kb2 keratinocyte kgf kgf111 kgf31 kgf91 kgfr neutralized neutralizing reciprocal structurally	abl adaptor aml1 amongst arising betapdgf chimeric coding dimerization elicits ets folding gtpases hetero homo homodimer homophilic module oligomerize oncogenic property reveals sam scaffolding shared sterile tel threonine
Tagcloud (Intersection) ?