FGFR2 and FGF23

Number of citations of the paper that reports this interaction (PMID 12032146)
32

Data Source:
HPRD (in vitro)

		FGFR2	FGF23
Gene Name		fibroblast growth factor receptor 2	fibroblast growth factor 23
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Cell Surface Membrane Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Extracellular Matrix Intracellular Membrane-bounded Organelle Excitatory Synapse	Extracellular Region Extracellular Space
	Molecular Function	Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Heparin Binding Fibroblast Growth Factor Binding Protein Homodimerization Activity	Type 1 Fibroblast Growth Factor Receptor Binding Growth Factor Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Ureteric Bud Development In Utero Embryonic Development Epithelial To Mesenchymal Transition Positive Regulation Of Mesenchymal Cell Proliferation Outflow Tract Septum Morphogenesis Membranous Septum Morphogenesis Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Axonogenesis Neuromuscular Junction Development Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Smoothened Signaling Pathway Post-embryonic Development Embryonic Pattern Specification Organ Morphogenesis Regulation Of Cell Fate Commitment Positive Regulation Of Phospholipase Activity Morphogenesis Of Embryonic Epithelium Peptidyl-tyrosine Phosphorylation Orbitofrontal Cortex Development Ventricular Zone Neuroblast Division Pyramidal Neuron Development Gland Morphogenesis Positive Regulation Of Wnt Signaling Pathway Bone Mineralization Lung Development Epithelial Cell Differentiation Midbrain Development Otic Vesicle Formation Hair Follicle Morphogenesis Lacrimal Gland Development Regulation Of Osteoblast Proliferation Multicellular Organism Growth Organ Growth Fibroblast Growth Factor Receptor Signaling Pathway Involved In Negative Regulation Of Apoptotic Process In Bone Marrow Fibroblast Growth Factor Receptor Signaling Pathway Involved In Hemopoiesis Fibroblast Growth Factor Receptor Signaling Pathway Involved In Positive Regulation Of Cell Proliferation In Bone Marrow Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Fc-epsilon Receptor Signaling Pathway Regulation Of Multicellular Organism Growth Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Inner Ear Morphogenesis Odontogenesis Positive Regulation Of MAPK Cascade Innate Immune Response Cell Fate Commitment Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Lung Alveolus Development Mesodermal Cell Differentiation Synaptic Vesicle Transport Embryonic Digestive Tract Morphogenesis Embryonic Organ Morphogenesis Digestive Tract Development Embryonic Organ Development Reproductive Structure Development Positive Regulation Of Smooth Muscle Cell Proliferation Embryonic Cranial Skeleton Morphogenesis Skeletal System Morphogenesis Epidermis Morphogenesis Branching Morphogenesis Of A Nerve Mesenchymal Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Cell Division Ventricular Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Cardiac Muscle Cell Proliferation Limb Bud Formation Bone Development Bone Morphogenesis Coronal Suture Morphogenesis Branching Involved In Prostate Gland Morphogenesis Branching Involved In Salivary Gland Morphogenesis Bud Elongation Involved In Lung Branching Lung Lobe Morphogenesis Lung-associated Mesenchyme Development Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Prostate Gland Morphogenesis Prostate Epithelial Cord Elongation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification Lateral Sprouting From An Epithelium Mammary Gland Bud Formation Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Branch Elongation Involved In Salivary Gland Morphogenesis Branching Involved In Labyrinthine Layer Morphogenesis Regulation Of Branching Involved In Prostate Gland Morphogenesis Regulation Of Morphogenesis Of A Branching Structure Mesenchymal Cell Differentiation Involved In Lung Development Mesenchymal Cell Proliferation Involved In Lung Development Endodermal Digestive Tract Morphogenesis Lens Fiber Cell Development Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Canonical Wnt Signaling Pathway	Phosphate-containing Compound Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Phosphate Transport Positive Regulation Of Vitamin D 24-hydroxylase Activity Cell Differentiation Negative Regulation Of Bone Mineralization Cellular Phosphate Ion Homeostasis Fc-epsilon Receptor Signaling Pathway Vitamin D Catabolic Process Innate Immune Response Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Hormone Secretion Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Phosphate Ion Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway
Pathways		Signaling by FGFR2 amplification mutants Signaling by FGFR2 mutants Signaling by FGFR in disease Signaling by FGFR mutants Activated point mutants of FGFR2	Signaling by the B Cell Receptor (BCR) Phospholipase C-mediated cascade Signaling by FGFR in disease SHC-mediated cascade Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Signaling by FGFR2 mutants DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade Signaling by activated point mutants of FGFR1 Signaling by FGFR1 mutants PI3K Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer Activated point mutants of FGFR2 PI3K events in ERBB4 signaling Signaling by ERBB2 FGFR4 ligand binding and activation Signaling by EGFR Signaling by FGFR3 mutants Downstream signal transduction Signaling by activated point mutants of FGFR3 Fc epsilon receptor (FCERI) signaling Signaling by FGFR mutants Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling Downstream signaling of activated FGFR FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR1c and Klotho ligand binding and activation FGFR2c ligand binding and activation FGFR ligand binding and activation Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane FGFR3 ligand binding and activation Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR Klotho-mediated ligand binding FGFR2 ligand binding and activation FRS2-mediated cascade IRS-mediated signalling FGFR1 ligand binding and activation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade
Drugs		Palifermin Thalidomide SU4984 4-[4-(1-Amino-1-Methylethyl)Phenyl]-5-Chloro-N-[4-(2-Morpholin-4-Ylethyl)Phenyl]Pyrimidin-2-Amine Regorafenib Ponatinib
Diseases
GWAS		Breast cancer ( 21263130 20872241 23354978 17529967 23535729 17529973 22951594 20453838 19330030 21060860) Prostate-specific antigen levels ( 21160077)	Colorectal cancer ( 23263487) Phosphorus levels ( 20558539)
Protein-Protein Interactions		21 interactors: APP CACNA1D EPHA4 FGF1 FGF10 FGF17 FGF18 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 ITGA5 NEDD4 PAK4 PLCG1 PPM1A PTK2B	3 interactors: FGFR2 FGFR3 PHEX
Entrez ID		2263	8074
HPRD ID		01492	05648
Ensembl ID		ENSG00000066468	ENSG00000118972
Uniprot IDs		D2CGD1 P21802	Q9GZV9
PDB IDs		1DJS 1E0O 1EV2 1GJO 1II4 1IIL 1NUN 1OEC 1WVZ 2FDB 2PSQ 2PVF 2PVY 2PWL 2PY3 2PZ5 2PZP 2PZR 2Q0B 3B2T 3CAF 3CLY 3CU1 3DAR 3EUU 3OJ2 3OJM 3RI1 4J95 4J96 4J97 4J98 4J99	2P39
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Phosphatidylinositol-mediated Signaling Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Response To Insulin Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Innate Immune Response Response To Peptide Hormone Immune Response-regulating Signaling Pathway Cellular Response To Organonitrogen Compound Response To Peptide Cell Surface Receptor Signaling Pathway Immune Response Cellular Response To Hormone Stimulus Response To Organonitrogen Compound Response To Hormone Defense Response Immune System Process Signal Transduction Cellular Response To Organic Substance Regulation Of Immune Response Cell-cell Signaling Signaling Positive Regulation Of Cell Division Cell Communication Regulation Of Immune System Process Positive Regulation Of Cell Proliferation Intracellular Signal Transduction Anatomical Structure Morphogenesis Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Stimulus Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Cell Differentiation Response To Stress System Development	Bone Mineralization Biomineral Tissue Development Ossification Lens Fiber Cell Development Lens Fiber Cell Differentiation Negative Regulation Of Mitotic Nuclear Division Skeletal System Development Lung Alveolus Development Digestive Tract Morphogenesis Positive Regulation Of Phospholipase Activity Negative Regulation Of Cell Division Midbrain Development Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Smoothened Signaling Pathway Lens Development In Camera-type Eye Organ Growth Cell-cell Signaling Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Mitotic Nuclear Division Bone Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Epithelial Cell Proliferation Phosphatidylinositol-mediated Signaling Digestive Tract Development Developmental Growth Involved In Morphogenesis Insulin Receptor Signaling Pathway Digestive System Development Coronal Suture Morphogenesis Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Involved In Positive Regulation Of Cell Proliferation In Bone Marrow Fibroblast Growth Factor Receptor Signaling Pathway Involved In Hemopoiesis Fibroblast Growth Factor Receptor Signaling Pathway Involved In Negative Regulation Of Apoptotic Process In Bone Marrow Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Wnt Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Inner Ear Development Regulation Of ERK1 And ERK2 Cascade Epithelial Cell Development Negative Regulation Of Apoptotic Process In Bone Marrow Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Negative Regulation Of Mitotic Cell Cycle Neurotrophin Signaling Pathway
Tagcloud ?		altogether basic bfgf bfgf1 bfgf55 bfgf75 bk1 bk2 chimera chimeras confer fgfr1 fgfr4 fibroblast gfg interacted kb1 kb2 keratinocyte kgf kgf111 kgf31 kgf91 kgfr neutralized neutralizing reciprocal structurally	aging camp clearly cleavage closely deficiency encodes extends importantly intracellular klotho lifespan longevity overexpression p21 participate participates pkc premature reasons secreted shows summarize suppresses suppressor tgf transforming transmembrane wnt
Tagcloud (Difference) ?		altogether basic bfgf bfgf1 bfgf55 bfgf75 bk1 bk2 chimera chimeras confer fgfr1 fgfr4 fibroblast gfg interacted kb1 kb2 keratinocyte kgf kgf111 kgf31 kgf91 kgfr neutralized neutralizing reciprocal structurally	aging camp clearly cleavage closely deficiency encodes extends importantly intracellular klotho lifespan longevity overexpression p21 participate participates pkc premature reasons secreted shows summarize suppresses suppressor tgf transforming transmembrane wnt
Tagcloud (Intersection) ?