ITGB7 and EED

Number of citations of the paper that reports this interaction (PubMedID 9765275)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		ITGB7	EED
Description		integrin subunit beta 7	embryonic ectoderm development
Image
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Membrane Integrin Alpha4-beta7 Complex Receptor Complex Extracellular Exosome	Sex Chromatin Nucleus Nucleoplasm Chromatin Silencing Complex Chromosome Cytosol ESC/E(Z) Complex Pronucleus
	Molecular Function	Virus Receptor Activity Integrin Binding Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding	Transcription Corepressor Binding Chromatin Binding Protein Binding Enzyme Activator Activity Nucleosome Binding Identical Protein Binding
	Biological Process	Immune Response In Gut-associated Lymphoid Tissue Cell-matrix Adhesion Involved In Ameboidal Cell Migration Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Receptor Clustering Symbiont Entry Into Host Cell Leukocyte Migration Leukocyte Tethering Or Rolling T Cell Migration Cell-cell Adhesion	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Spinal Cord Development Heterochromatin Formation Negative Regulation Of DNA-templated Transcription Oligodendrocyte Differentiation Genomic Imprinting Facultative Heterochromatin Formation Cellular Response To Leukemia Inhibitory Factor Regulation Of Adaxial/abaxial Pattern Formation
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions	PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Regulation of PD-L1(CD274) transcription
Drugs		R1295 Vedolizumab Etrolizumab
Diseases
GWAS		Obesity-related traits ( 23251661) Type 1 diabetes ( 34127860)	Refractive error ( 32231278) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		15 interacting genes: CDH1 DAB1 DOK1 EED FLNA FN1 ITGA4 ITGAE MADCAM1 PRKCB PRKCD RACK1 TLN1 TNS2 VCAM1	42 interacting genes: AEBP2 ANXA5 AR BRCA1 CDK2AP2 CTSL DNMT1 DNMT3A DNMT3B DUSP23 EHMT1 EPC2 EZH1 EZH2 FAM200C FHL1 H1-1 H3C1 HDAC1 HDAC2 HDAC3 ITGA4 ITGAE ITGB7 MAP1LC3B NUDT21 PJA1 PPP1CA PPP1R8 PRDM14 RACK1 RPS10 SELENBP1 SMYD3 SRPK2 TGS1 TRIM55 TRIM63 TSC22D1 UBE2W YY1 ZFP42
Entrez ID		3695	8726
HPRD ID		00948	09343
Ensembl ID		ENSG00000139626	ENSG00000074266
Uniprot IDs		P26010	E9PJK2 O75530
PDB IDs		2BRQ 3V4P 3V4V 8ZJF	3IIW 3IIY 3IJ0 3IJ1 3IJC 3JPX 3JZG 3JZH 3JZN 3K26 3K27 4W2R 4X3E 5GSA 5H13 5H14 5H15 5H17 5H19 5H24 5H25 5HYN 5IJ7 5IJ8 5K0M 5LS6 5TTW 5U5H 5U5K 5U5T 5U62 5U69 5U6D 5U8A 5U8F 5WG6 5WP3 5WUK 6B3W 6C23 6C24 6LO2 6SFB 6SFC 6U4Y 6V3X 6V3Y 6W7F 6W7G 6WKR 6YVI 6YVJ 7KSO 7KSR 7KTP 7KXT 7MSB 7MSD 7P3C 7P3G 7P3J 7QJG 7QJU 7QK4 7SI4 7SI5 7TD5 8EQV 8FYH 8T9G 8TAS 8TB9 8VMI 8VML 8VNV 8VNZ 9C8U 9DCH
Enriched GO Terms of Interacting Partners?		Cell-cell Adhesion Cell Adhesion Integrin-mediated Signaling Pathway Cell-matrix Adhesion Regulation Of Cell Adhesion Cell-substrate Adhesion Leukocyte Tethering Or Rolling Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Transport Cell Surface Receptor Signaling Pathway Heterotypic Cell-cell Adhesion Protein Kinase C Signaling Positive Regulation Of Protein Import Into Nucleus Cellular Response To Oxygen-containing Compound Positive Regulation Of Establishment Of Protein Localization Integrin Binding Cell Migration Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Receptor Clustering Cell-cell Adhesion Mediated By Integrin Leukocyte Cell-cell Adhesion Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport B Cell Activation Cell Motility Perinuclear Region Of Cytoplasm Extracellular Exosome Regulation Of Protein Transport Integrin Activation Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Protein Localization Regulation Of Cellular Response To Insulin Stimulus Enzyme Activator Activity Positive Regulation Of Intracellular Protein Transport Cell Adhesion Molecule Binding Positive Regulation Of Protein Localization To Nucleus Regulation Of Establishment Of Protein Localization Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Cell Migration Plasma Membrane Protein Activation Cascade Positive Regulation Of Cell Motility Protein Localization To Membrane Cadherin Binding Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Locomotion Regulation Of Cell Migration Regulation Of Cell Motility	Chromatin Organization Negative Regulation Of Gene Expression, Epigenetic Chromatin Remodeling Heterochromatin Formation Epigenetic Regulation Of Gene Expression Methyltransferase Activity Nucleus Methylation Constitutive Heterochromatin Formation Nucleoplasm DNA (cytosine-5-)-methyltransferase Activity Protein Lysine Delactylase Activity DNA Methylation-dependent Constitutive Heterochromatin Formation Negative Regulation Of Nucleobase-containing Compound Metabolic Process ESC/E(Z) Complex Protein Decrotonylase Activity Histone Decrotonylase Activity Chromatin Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone H3K27 Methyltransferase Activity Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of Muscle Cell Differentiation Regulation Of Transcription By RNA Polymerase II Histone Methyltransferase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Striated Muscle Cell Differentiation Protein Lysine Deacetylase Activity Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Protein De-2-hydroxyisobutyrylase Activity Cell-matrix Adhesion Involved In Ameboidal Cell Migration Integrin Alpha4-beta7 Complex Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Transcription Corepressor Binding Transferase Activity Heterochromatin NuRD Complex Transcription Corepressor Activity Negative Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Activity RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA Binding DNA-methyltransferase Activity Histone H3K27 Trimethyltransferase Activity Fungiform Papilla Formation Circadian Regulation Of Gene Expression Regulation Of Apoptotic Process
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