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ITGB7 and CDH1
Number of citations of the paper that reports this interaction (PubMedID
35559673
)
71
Data Source:
BioGRID
(genetic interference)
HPRD
(in vivo)
ITGB7
CDH1
Description
integrin subunit beta 7
cadherin 1
Image
GO Annotations
Cellular Component
Plasma Membrane
Focal Adhesion
Integrin Complex
Cell Surface
Membrane
Integrin Alpha4-beta7 Complex
Receptor Complex
Extracellular Exosome
Extracellular Region
Cytoplasm
Endosome
Golgi Apparatus
Trans-Golgi Network
Plasma Membrane
Adherens Junction
Cytoplasmic Side Of Plasma Membrane
Actin Cytoskeleton
Membrane
Lateral Plasma Membrane
Catenin Complex
Flotillin Complex
Lamellipodium
Cell Junction
Desmosome
Cortical Actin Cytoskeleton
Apical Junction Complex
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Anchoring Junction
Postsynapse
Glutamatergic Synapse
Molecular Function
Virus Receptor Activity
Integrin Binding
Protein Binding
Metal Ion Binding
Cell Adhesion Molecule Binding
Calcium Ion Binding
Protein Binding
Beta-catenin Binding
Ankyrin Binding
GTPase Activating Protein Binding
Identical Protein Binding
Gamma-catenin Binding
Cadherin Binding
Metal Ion Binding
Cell Adhesion Molecule Binding
Cell-cell Adhesion Mediator Activity
Protein Tyrosine Kinase Binding
Biological Process
Immune Response In Gut-associated Lymphoid Tissue
Cell-matrix Adhesion Involved In Ameboidal Cell Migration
Cell Adhesion
Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Cell Adhesion Mediated By Integrin
Heterotypic Cell-cell Adhesion
Substrate Adhesion-dependent Cell Spreading
Receptor Clustering
Symbiont Entry Into Host Cell
Leukocyte Migration
Leukocyte Tethering Or Rolling
T Cell Migration
Cell-cell Adhesion
Cell Morphogenesis
Desmosome Assembly
Cell-cell Junction Assembly
Cell Adhesion
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Synapse Assembly
Response To Xenobiotic Stimulus
Response To Toxic Substance
Regulation Of Gene Expression
Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Cell Migration
Pituitary Gland Development
Negative Regulation Of Cell-cell Adhesion
Negative Regulation Of Cell Migration
Negative Regulation Of Axon Extension
Neuron Projection Development
Cell Junction Assembly
Adherens Junction Organization
Positive Regulation Of Protein Import Into Nucleus
Cell-cell Adhesion Mediated By Cadherin
Positive Regulation Of DNA-templated Transcription
Regulation Of Transport
Cellular Response To Lithium Ion
Response To Heparin
Cellular Response To Indole-3-methanol
Protein Localization To Plasma Membrane
Cell-cell Adhesion
Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission
Response To Gram-positive Bacterium
Positive Regulation Of Protein Localization
Pathways
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Integrin cell surface interactions
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Integrin cell surface interactions
Apoptotic cleavage of cell adhesion proteins
Adherens junctions interactions
RHO GTPases activate IQGAPs
InlA-mediated entry of Listeria monocytogenes into host cells
Regulation of CDH1 Function
Regulation of CDH1 mRNA translation by microRNAs
Degradation of CDH1
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Formation of definitive endoderm
Transcriptional and post-translational regulation of MITF-M expression and activity
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
Developmental Lineage of Mammary Gland Luminal Epithelial Cells
Developmental Lineage of Mammary Gland Myoepithelial Cells
Developmental Lineage of Mammary Stem Cells
Drugs
R1295
Vedolizumab
Etrolizumab
Diseases
Penile cancer
Breast cancer
Gastric cancer
Nasopharyngeal cancer
Hepatocellular carcinoma
Thyroid cancer
GWAS
Obesity-related traits (
23251661
)
Type 1 diabetes (
34127860
)
Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease (
34020725
)
Colorectal cancer (
19011631
)
Colorectal cancer or advanced adenoma (
30510241
)
Cutaneous malignant melanoma (
26237428
32341527
)
Glycated hemoglobin levels (
34059833
)
High light scatter reticulocyte count (
27863252
32888494
)
High light scatter reticulocyte percentage of red cells (
27863252
32888494
)
Immature fraction of reticulocytes (
32888494
)
Late-onset Alzheimer's disease (
27770636
)
Mean corpuscular hemoglobin (
27863252
32888494
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean corpuscular volume (
32888494
27863252
)
Nevus count or cutaneous melanoma (
32341527
)
Red cell distribution width (
32888494
)
Reticulocyte count (
32888494
27863252
)
Reticulocyte fraction of red cells (
27863252
32888494
)
Ulcerative colitis (
19915572
)
Interacting Genes
15 interacting genes:
CDH1
DAB1
DOK1
EED
FLNA
FN1
ITGA4
ITGAE
MADCAM1
PRKCB
PRKCD
RACK1
TLN1
TNS2
VCAM1
74 interacting genes:
ACTR3
AKT1
ANAPC7
AOPEP
ARHGAP32
ARVCF
AURKB
CA9
CASP3
CASP8
CBLL1
CCNB1
CDC42
CDK8
CHEK1
CSE1L
CSNK2A1
CTNNA1
CTNNB1
CTNND1
CTNND2
DNMT3A
EGFR
ERBIN
EZR
FADD
FARP2
FER
FGFR1
FYN
GALNT12
GNA12
GNA13
GSK3B
HDAC1
HDAC2
HEMGN
HRAS
HSD17B3
IQGAP1
IRS1
ITGAE
ITGB7
JUP
KEAP1
MAD2L2
MAP2K1
MAPK3
MKI67
MSANTD3
MYO6
NANS
NDRG1
NEDD9
NFE2L2
PIP5K1C
PKD1
PKP4
PPP1CA
PSEN1
PTPN14
PTPRF
PTPRM
PTTG1
RAB8B
RRM2
SFRP2
STX17
TMOD1
UCA1
UCHL3
VCL
YES1
ZNF510
Entrez ID
3695
999
HPRD ID
00948
01885
Ensembl ID
ENSG00000139626
ENSG00000039068
Uniprot IDs
P26010
A0A0U2ZQU7
B3GN61
P12830
Q9UII7
PDB IDs
2BRQ
3V4P
3V4V
8ZJF
1O6S
2O72
2OMT
2OMU
2OMV
2OMX
2OMY
2OMZ
3FF7
3FF8
3L6X
3L6Y
4ZT1
4ZTE
6CXY
6OLE
6OLF
6OLG
6VEL
7STZ
8H62
Enriched GO Terms of Interacting Partners
?
Cell-cell Adhesion
Cell Adhesion
Integrin-mediated Signaling Pathway
Cell-matrix Adhesion
Regulation Of Cell Adhesion
Cell-substrate Adhesion
Leukocyte Tethering Or Rolling
Leukocyte Adhesion To Vascular Endothelial Cell
Regulation Of Multicellular Organismal Process
Positive Regulation Of Protein Transport
Cell Surface Receptor Signaling Pathway
Heterotypic Cell-cell Adhesion
Protein Kinase C Signaling
Positive Regulation Of Protein Import Into Nucleus
Cellular Response To Oxygen-containing Compound
Positive Regulation Of Establishment Of Protein Localization
Integrin Binding
Cell Migration
Negative Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Cellular Response To Insulin Stimulus
Receptor Clustering
Cell-cell Adhesion Mediated By Integrin
Leukocyte Cell-cell Adhesion
Regulation Of Protein Import Into Nucleus
Positive Regulation Of Nucleocytoplasmic Transport
B Cell Activation
Cell Motility
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Regulation Of Protein Transport
Integrin Activation
Regulation Of Insulin Receptor Signaling Pathway
Positive Regulation Of Protein Localization
Regulation Of Cellular Response To Insulin Stimulus
Enzyme Activator Activity
Positive Regulation Of Intracellular Protein Transport
Cell Adhesion Molecule Binding
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Establishment Of Protein Localization
Diacylglycerol-dependent Serine/threonine Kinase Activity
Positive Regulation Of Cell Migration
Plasma Membrane
Protein Activation Cascade
Positive Regulation Of Cell Motility
Protein Localization To Membrane
Cadherin Binding
Regulation Of Nucleocytoplasmic Transport
Positive Regulation Of Locomotion
Regulation Of Cell Migration
Regulation Of Cell Motility
Cell-cell Adhesion
Adherens Junction
Cell Adhesion
Regulation Of Cell Motility
Regulation Of Cell Migration
Regulation Of Locomotion
Cell Surface Receptor Signaling Pathway
Cytoplasm
Focal Adhesion
Cadherin Binding
Regulation Of Intracellular Signal Transduction
Regulation Of Cellular Component Organization
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell-cell Junction
Regulation Of Signal Transduction
Intracellular Signal Transduction
Signal Transduction
Anchoring Junction
Regulation Of Signaling
Regulation Of Cell Communication
Plasma Membrane
Regulation Of Apoptotic Signaling Pathway
Regulation Of Cell Projection Organization
Regulation Of Mitotic Cell Cycle
Response To Xenobiotic Stimulus
Cell Cortex
Negative Regulation Of Apoptotic Signaling Pathway
Anatomical Structure Morphogenesis
Regulation Of Protein Catabolic Process
Regulation Of Cell Adhesion
Regulation Of Protein Metabolic Process
Positive Regulation Of Cell Migration
Cell Motility
Regulation Of Cell Population Proliferation
Positive Regulation Of Signaling
Regulation Of Multicellular Organismal Process
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Regulation Of Cell Cycle
Nucleus
Positive Regulation Of Cell Motility
Negative Regulation Of Cell Motility
Cytosol
Cytoskeleton
Positive Regulation Of Locomotion
ERBB Signaling Pathway
Cell Migration
Positive Regulation Of Signal Transduction
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Cellular Component Organization
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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