ITGB7 and ITGAE

Number of citations of the paper that reports this interaction (PubMedID 8119947)
0

Data Source:
HPRD (in vivo)

		ITGB7	ITGAE
Description		integrin subunit beta 7	integrin subunit alpha E
Image
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Membrane Integrin Alpha4-beta7 Complex Receptor Complex Extracellular Exosome	Plasma Membrane Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Virus Receptor Activity Integrin Binding Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding	Signaling Receptor Activity Metal Ion Binding
	Biological Process	Immune Response In Gut-associated Lymphoid Tissue Cell-matrix Adhesion Involved In Ameboidal Cell Migration Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Receptor Clustering Symbiont Entry Into Host Cell Leukocyte Migration Leukocyte Tethering Or Rolling T Cell Migration Cell-cell Adhesion	Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell-cell Adhesion
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions	Integrin cell surface interactions
Drugs		R1295 Vedolizumab Etrolizumab
Diseases
GWAS		Obesity-related traits ( 23251661) Type 1 diabetes ( 34127860)	Attention deficit hyperactivity disorder ( 18839057)
Interacting Genes		15 interacting genes: CDH1 DAB1 DOK1 EED FLNA FN1 ITGA4 ITGAE MADCAM1 PRKCB PRKCD RACK1 TLN1 TNS2 VCAM1	5 interacting genes: CDH1 CHFR EED ITGB7 TRIM54
Entrez ID		3695	3682
HPRD ID		00948	05249
Ensembl ID		ENSG00000139626	ENSG00000083457
Uniprot IDs		P26010	P38570
PDB IDs		2BRQ 3V4P 3V4V 8ZJF	8ZJF
Enriched GO Terms of Interacting Partners?		Cell-cell Adhesion Cell Adhesion Integrin-mediated Signaling Pathway Cell-matrix Adhesion Regulation Of Cell Adhesion Cell-substrate Adhesion Leukocyte Tethering Or Rolling Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Transport Cell Surface Receptor Signaling Pathway Heterotypic Cell-cell Adhesion Protein Kinase C Signaling Positive Regulation Of Protein Import Into Nucleus Cellular Response To Oxygen-containing Compound Positive Regulation Of Establishment Of Protein Localization Integrin Binding Cell Migration Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Receptor Clustering Cell-cell Adhesion Mediated By Integrin Leukocyte Cell-cell Adhesion Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport B Cell Activation Cell Motility Perinuclear Region Of Cytoplasm Extracellular Exosome Regulation Of Protein Transport Integrin Activation Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Protein Localization Regulation Of Cellular Response To Insulin Stimulus Enzyme Activator Activity Positive Regulation Of Intracellular Protein Transport Cell Adhesion Molecule Binding Positive Regulation Of Protein Localization To Nucleus Regulation Of Establishment Of Protein Localization Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Cell Migration Plasma Membrane Protein Activation Cascade Positive Regulation Of Cell Motility Protein Localization To Membrane Cadherin Binding Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Locomotion Regulation Of Cell Migration Regulation Of Cell Motility	Cytoplasmic Side Of Plasma Membrane Cell Adhesion Molecule Binding Symbiont Entry Into Host Cell Cell-matrix Adhesion Involved In Ameboidal Cell Migration Virus Receptor Activity Integrin Alpha4-beta7 Complex Fourth Ventricle Development Regulation Of Adaxial/abaxial Pattern Formation Meiotic Spindle Checkpoint Signaling Myosin II Filament Negative Regulation Of Metaphase/anaphase Transition Of Meiotic Cell Cycle Response To Heparin Cellular Response To Indole-3-methanol Cell Adhesion Cell Migration Response To Indole-3-methanol Response To Gram-positive Bacterium Lamellipodium Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Desmosome Assembly Immune Response In Gut-associated Lymphoid Tissue Biological Process Involved In Interaction With Host Third Ventricle Development Pronucleus Sex Chromatin Negative Regulation Of Meiotic Cell Cycle Phase Transition Meiotic Cell Cycle Checkpoint Signaling Flotillin Complex Positive Regulation Of Protein Transport Actomyosin Substrate-dependent Cell Migration, Cell Extension Postsynaptic Actin Cytoskeleton Ventricular Cardiac Muscle Cell Development Supramolecular Fiber GTPase Activating Protein Binding Cerebellar Purkinje Cell Layer Development Chromatin Silencing Complex Cell Motility Gamma-catenin Binding Desmosome Organization Cellular Response To Lithium Ion Positive Regulation Of Establishment Of Protein Localization Protein Localization To Membrane Adult Heart Development Cardiac Myofibril Assembly Lateral Ventricle Development ESC/E(Z) Complex Facultative Heterochromatin Formation
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