YTHDC2

Description		YTH N6-methyladenosine RNA binding protein C2
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On RNA Hydrolase Activity ATP Hydrolysis Activity 3'-5' RNA Helicase Activity RNA Polymerase Binding N6-methyladenosine-containing RNA Reader Activity
	Biological Process	Spermatogenesis Spermatid Development Cell Differentiation Response To Tumor Necrosis Factor Host-mediated Activation Of Viral Genome Replication Oogenesis Oocyte Development Meiotic Cell Cycle Germline Cell Cycle Switching, Mitotic To Meiotic Cell Cycle Response To Interleukin-1
Pathways		Nuclear RNA decay
Drugs
Diseases
GWAS		Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) F-cell distribution in sickle cell anaemia ( 21326311) Metabolite levels ( 23823483) Type 2 diabetes ( 30054458)
Interacting Genes		4 interacting genes: IRAK1 IRF4 PTEN SRPK2
Entrez ID		64848
HPRD ID		11690
Ensembl ID		ENSG00000047188
Uniprot IDs		Q9H6S0
PDB IDs		2YU6 6K6U 6LR2 9H35 9H36
Enriched GO Terms of Interacting Partners?		Regulation Of Smooth Muscle Cell Proliferation Toll Signaling Pathway Positive Regulation Of Biosynthetic Process Negative Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cell Population Proliferation Protein Serine Kinase Activity Defense Response Response To Other Organism Intracellular Signaling Cassette Defense Response To Other Organism Regulation Of RNA Metabolic Process Protein Phosphorylation Response To External Biotic Stimulus Positive Regulation Of Gene Expression Response To Stress Negative Regulation Of Cell Communication Interleukin-33-mediated Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Postsynaptic Specialization Assembly Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Neuron-neuron Synaptic Transmission Phosphatidylinositol Phosphate Phosphatase Activity Central Nervous System Myelin Maintenance Negative Regulation Of Cell Size Presynaptic Membrane Organization Schmidt-Lanterman Incisure Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Rhythmic Synaptic Transmission Anaphase-promoting Complex Binding Postsynaptic Density Assembly Forebrain Morphogenesis Negative Regulation Of Excitatory Postsynaptic Potential Presynaptic Membrane Assembly Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity R-loop Processing
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