PECAM1 and DSP

Number of citations of the paper that reports this interaction (PubMedID 10801826)
0

Data Source:
HPRD (in vivo, in vitro)

		PECAM1	DSP
Description		platelet and endothelial cell adhesion molecule 1	desmoplakin
Image
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Membrane Smooth Muscle Contractile Fiber Secretory Granule Membrane Platelet Alpha Granule Membrane Protein-containing Complex Cell-cell Contact Zone Membrane Raft Extracellular Exosome Anchoring Junction Cell Periphery	Cornified Envelope Nucleus Cytoplasm Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Fascia Adherens Intercalated Disc Membrane Basolateral Plasma Membrane Desmosome Extracellular Exosome Anchoring Junction Ficolin-1-rich Granule Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Protein Homodimerization Activity	RNA Binding Protein Kinase C Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Scaffold Protein Binding
	Biological Process	Angiogenesis Blood Vessel Development Endothelial Cell Development Endothelial Cell Morphogenesis Phagocytosis Immune Response Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Leukocyte Cell-cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway Rho Protein Signal Transduction Cell Recognition Cell Migration Regulation Of Cell Migration Positive Regulation Of Cell Migration Maintenance Of Blood-brain Barrier Monocyte Extravasation Wound Healing Vasodilation Positive Regulation Of MAPK Cascade Endothelial Cell Migration Diapedesis Detection Of Mechanical Stimulus Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Establishment Of Endothelial Barrier Bicellular Tight Junction Assembly Cellular Response To Mechanical Stimulus Glomerular Endothelium Development Neutrophil Extravasation Endothelial Cell-matrix Adhesion Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Protein Localization To Cell-cell Junction Positive Regulation Of Intracellular Signal Transduction	Desmosome Organization Ventricular Compact Myocardium Morphogenesis Epidermis Development Peptide Cross-linking Keratinocyte Differentiation Adherens Junction Organization Wound Healing Skin Development Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Epithelial Cell-cell Adhesion Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Protein Localization To Cell-cell Junction
Pathways		Platelet degranulation Cell surface interactions at the vascular wall PECAM1 interactions Integrin cell surface interactions Platelet sensitization by LDL Neutrophil degranulation High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope RND3 GTPase cycle RND1 GTPase cycle
Drugs			Zinc Artenimol Zinc acetate
Diseases			Striate palmoplantar keratoderma Skin fragility-woolly hair syndrome Arrhythmogenic right ventricular cardiomyopathy (ARVC) Naxos disease and Carvajal syndrome Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
GWAS		Appendicular lean mass ( 33097823) Coronary artery disease ( 29212778 32469254 33020668) Myocardial infarction ( 33532862) Pulse pressure ( 27841878 30578418) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189) Systolic blood pressure ( 27841878)	Chronic obstructive pulmonary disease ( 28166215 30804561) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Idiopathic pulmonary fibrosis ( 29066090 31710517) Interstitial lung disease ( 23583980) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Numerical cognitive ability ( 31620175) PR interval ( 32439900) Response to fenofibrate (triglyceride levels) ( 27002377) Resting heart rate ( 27798624)
Interacting Genes		22 interacting genes: CD38 CSK CTNNB1 DSP EFNB2 FYN HCK INPP5D ITGA5 ITGB3 JUP LCK LYN PIK3R1 PLCG1 PRKCE PRPF40A PTPN11 PTPN6 SRC XRCC6 YES1	36 interacting genes: ARID3A CASP10 CASP2 CASP4 CASP6 CASP7 CASP9 CDC42 CDH5 COL17A1 COPS6 DES DSC1 ENO3 EVPL H19 IVL JUP KRT1 KRT5 KRT6A MTDH PECAM1 PKP1 PKP2 PKP3 PKP4 PRKACA PRKCE PTEN RNF10 TTC3 UCHL5 USP7 VIM WEE2-AS1
Entrez ID		5175	1832
HPRD ID		01425	00513
Ensembl ID		ENSG00000261371	ENSG00000096696
Uniprot IDs		P16284	A0AAQ5BH43 B4DKX6 P15924
PDB IDs		2KY5 5C14 5GNI	1LM5 1LM7 3R6N 5DZZ
Enriched GO Terms of Interacting Partners?		T Cell Costimulation Positive Regulation Of Immune System Process Positive Regulation Of Multicellular Organismal Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Activation Cell Migration Activation Of Immune Response Regulation Of Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Lymphocyte Activation Immune Response-activating Signaling Pathway Regulation Of Cell Activation Cell Motility Fc-gamma Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Activation Negative Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Cell-cell Junction Regulation Of Multicellular Organismal Process Non-membrane Spanning Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Immune System Process Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Immune Response Regulation Of T Cell Activation Negative Regulation Of Inflammatory Response To Antigenic Stimulus Negative Regulation Of Immune Response Regulation Of Transport Positive Regulation Of Cell-cell Adhesion Enzyme-linked Receptor Protein Signaling Pathway Antigen Receptor-mediated Signaling Pathway Regulation Of Cell-cell Adhesion Regulation Of Developmental Process Phosphotyrosine Residue Binding Positive Regulation Of T Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Immune Effector Process Peptidyl-tyrosine Phosphorylation Ephrin Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Innate Immune Response Regulation Of Defense Response Regulation Of Cell Population Proliferation Cell Activation	Cornified Envelope Desmosome Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Cysteine-type Endopeptidase Activity Cell-cell Junction Organization Desmosome Organization Cell Junction Assembly Intermediate Filament Organization Cysteine-type Peptidase Activity Cell-cell Junction Anchoring Junction Desmosome Assembly Cell Junction Organization Positive Regulation Of Neuron Apoptotic Process Cell-cell Junction Assembly Cytoplasm Peptidase Activity Keratinization Alpha-catenin Binding Adherens Junction Intermediate Filament Cytoskeleton Cadherin Binding Desmosome Maintenance Cytoskeleton Organization Cytosol Peptide Cross-linking Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Cell-cell Adhesion Cell Adhesion Epidermis Development Cellular Component Assembly Positive Regulation Of Signal Transduction Regulation Of Neuron Apoptotic Process Execution Phase Of Apoptosis Proteolysis Cellular Response To Staurosporine Protein Metabolic Process Protein Processing Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Protein Maturation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Periphery Response To Indole-3-methanol Cell Junction Structural Constituent Of Cytoskeleton Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication
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