PECAM1 and CD38

Number of citations of the paper that reports this interaction (PubMedID 9551996)
0

Data Source:
HPRD (in vitro)

		PECAM1	CD38
Description		platelet and endothelial cell adhesion molecule 1	CD38 molecule
Image
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Membrane Smooth Muscle Contractile Fiber Secretory Granule Membrane Platelet Alpha Granule Membrane Protein-containing Complex Cell-cell Contact Zone Membrane Raft Extracellular Exosome Anchoring Junction Cell Periphery	Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Nuclear Membrane Extracellular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Protein Homodimerization Activity	Transferase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Phosphorus-oxygen Lyase Activity Identical Protein Binding NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
	Biological Process	Angiogenesis Blood Vessel Development Endothelial Cell Development Endothelial Cell Morphogenesis Phagocytosis Immune Response Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Leukocyte Cell-cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway Rho Protein Signal Transduction Cell Recognition Cell Migration Regulation Of Cell Migration Positive Regulation Of Cell Migration Maintenance Of Blood-brain Barrier Monocyte Extravasation Wound Healing Vasodilation Positive Regulation Of MAPK Cascade Endothelial Cell Migration Diapedesis Detection Of Mechanical Stimulus Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Establishment Of Endothelial Barrier Bicellular Tight Junction Assembly Cellular Response To Mechanical Stimulus Glomerular Endothelium Development Neutrophil Extravasation Endothelial Cell-matrix Adhesion Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Protein Localization To Cell-cell Junction Positive Regulation Of Intracellular Signal Transduction	Response To Hypoxia Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Female Pregnancy Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Hormone Negative Regulation Of Neuron Projection Development Artery Smooth Muscle Contraction NAD+ Metabolic Process Positive Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Positive Regulation Of Insulin Secretion Response To Estradiol Response To Retinoic Acid Response To Progesterone Response To Hydroperoxide Response To Cytokine B Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Bone Resorption Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Vasoconstriction B Cell Receptor Signaling Pathway Long-term Synaptic Depression Response To Interleukin-1 Apoptotic Signaling Pathway
Pathways		Platelet degranulation Cell surface interactions at the vascular wall PECAM1 interactions Integrin cell surface interactions Platelet sensitization by LDL Neutrophil degranulation High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Nicotinate metabolism
Drugs			Daratumumab Isatuximab Mezagitamab
Diseases
GWAS		Appendicular lean mass ( 33097823) Coronary artery disease ( 29212778 32469254 33020668) Myocardial infarction ( 33532862) Pulse pressure ( 27841878 30578418) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189) Systolic blood pressure ( 27841878)	Neurological blood protein biomarker levels ( 31320639) Parkinson's disease ( 27182965 28892059)
Interacting Genes		22 interacting genes: CD38 CSK CTNNB1 DSP EFNB2 FYN HCK INPP5D ITGA5 ITGB3 JUP LCK LYN PIK3R1 PLCG1 PRKCE PRPF40A PTPN11 PTPN6 SRC XRCC6 YES1	6 interacting genes: CBL CD4 CD9 FCGR3A LCK PECAM1
Entrez ID		5175	952
HPRD ID		01425	00116
Ensembl ID		ENSG00000261371	ENSG00000004468
Uniprot IDs		P16284	B4E006 P28907
PDB IDs		2KY5 5C14 5GNI	1YH3 1ZVM 2EF1 2HCT 2I65 2I66 2I67 2O3Q 2O3R 2O3S 2O3T 2O3U 2PGJ 2PGL 3DZF 3DZG 3DZH 3DZI 3DZJ 3DZK 3F6Y 3I9M 3I9N 3OFS 3RAJ 3ROK 3ROM 3ROP 3ROQ 3U4H 3U4I 4CMH 4F45 4F46 4OGW 4TMF 4XJS 4XJT 5F1K 5F1O 5F21 6EDR 6VUA 7DHA 7DUO 7VKE 8BYU 8D0M 8IL3 8P8C 8VAU 9GOX 9GOY
Enriched GO Terms of Interacting Partners?		T Cell Costimulation Positive Regulation Of Immune System Process Positive Regulation Of Multicellular Organismal Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Activation Cell Migration Activation Of Immune Response Regulation Of Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Lymphocyte Activation Immune Response-activating Signaling Pathway Regulation Of Cell Activation Cell Motility Fc-gamma Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Activation Negative Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Cell-cell Junction Regulation Of Multicellular Organismal Process Non-membrane Spanning Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Immune System Process Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Immune Response Regulation Of T Cell Activation Negative Regulation Of Inflammatory Response To Antigenic Stimulus Negative Regulation Of Immune Response Regulation Of Transport Positive Regulation Of Cell-cell Adhesion Enzyme-linked Receptor Protein Signaling Pathway Antigen Receptor-mediated Signaling Pathway Regulation Of Cell-cell Adhesion Regulation Of Developmental Process Phosphotyrosine Residue Binding Positive Regulation Of T Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Immune Effector Process Peptidyl-tyrosine Phosphorylation Ephrin Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Innate Immune Response Regulation Of Defense Response Regulation Of Cell Population Proliferation Cell Activation	Platelet Alpha Granule Membrane Membrane Raft External Side Of Plasma Membrane Plasma Membrane Cell Activation Regulation Of Cell Activation Fc-gamma Receptor Signaling Pathway Leukocyte Degranulation Protein Tyrosine Kinase Binding Phosphotyrosine Residue Binding Cell Adhesion Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Immune System Process Positive Regulation Of Lymphocyte Activation Clathrin-coated Endocytic Vesicle Membrane Interleukin-16 Binding Interleukin-16 Receptor Activity Positive Regulation Of Cell Activation Helper T Cell Enhancement Of Adaptive Immune Response Platelet Activation Protein Kinase Binding Positive Regulation Of Intracellular Signal Transduction Vesicle-mediated Transport Endocytosis Positive Regulation Of MAPK Cascade Lymphocyte Activation Regulated Exocytosis Response To Methamphetamine Hydrochloride Regulation Of Cell-cell Adhesion Low-affinity IgG Receptor Activity Immune Receptor Activity Endothelial Cell-matrix Adhesion Regulation Of Lymphocyte Activation Response To Ethanol Symbiont Entry Into Host Cell Cell Recognition Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Leukocyte Activation Myoblast Fusion Involved In Skeletal Muscle Regeneration Fc-gamma Receptor III Complex Import Into Cell Regulation Of Rap Protein Signal Transduction Membrane Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation T Cell Differentiation CD8 Receptor Binding Positive Regulation Of Protein Localization To Cell-cell Junction
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