FLT3 and UBE2L6

Number of citations of the paper that reports this interaction (PMID 20508617)
12

Data Source:
BioGRID (pull down)

		FLT3	UBE2L6
Gene Name		fms-related tyrosine kinase 3	ubiquitin-conjugating enzyme E2L 6
Image
Gene Ontology Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Lumen Cytosol Integral Component Of Plasma Membrane External Side Of Plasma Membrane Protein Complex	Cytosol
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Cytokine Receptor Activity Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding ATP Binding Protein Complex Binding Glucocorticoid Receptor Binding Protein Homodimerization Activity Phosphatidylinositol 3-kinase Binding	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity ISG15 Transferase Activity
	Biological Process	Leukocyte Homeostasis Myeloid Progenitor Cell Differentiation Pro-B Cell Differentiation Pro-T Cell Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Organonitrogen Compound Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Hemopoiesis B Cell Differentiation Organ Regeneration Common Myeloid Progenitor Cell Proliferation Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of B Cell Differentiation Lymphocyte Proliferation Protein Autophosphorylation Cellular Response To Cytokine Stimulus Cellular Response To Glucocorticoid Stimulus Dendritic Cell Differentiation	Cellular Protein Modification Process Protein Ubiquitination Cytokine-mediated Signaling Pathway Modification-dependent Protein Catabolic Process ISG15-protein Conjugation Negative Regulation Of Type I Interferon Production Innate Immune Response
Pathways			RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Antigen processing: Ubiquitination & Proteasome degradation Negative regulators of RIG-I/MDA5 signaling ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Class I MHC mediated antigen processing & presentation Antiviral mechanism by IFN-stimulated genes Adaptive Immune System Innate Immune System
Drugs		Sorafenib Sunitinib Ponatinib
Diseases
GWAS
Protein-Protein Interactions		14 interactors: CBL CBLB FIZ1 FLT3LG GRB2 IKBKG INPP5D NCK1 PTPN12 PTPN6 SH3BP2 SLA SOCS1 UBE2L6	37 interactors: ARHGDIA ARIH1 ARIH2 CBLC DTX3 FLT3 LONRF1 MAP3K1 MUL1 PARK2 PJA2 RAD23A RBCK1 RBX1 RNF122 RNF125 RNF144A RNF144B RNF150 RNF19A RNF216 RNF25 RNF4 RNF40 RUNX1 SIAH1 SIAH2 SPEN TOPORS TRAF7 TRIM25 TRIM27 TRIM8 UBA6 UBA7 UBC UBE3A
Entrez ID		2322	9246
HPRD ID		00635	04867
Ensembl ID		ENSG00000122025	ENSG00000156587
Uniprot IDs		P36888	O14933
PDB IDs		1RJB 3QS7 3QS9	1WZV 1WZW 2KJH
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Signal Transduction Regulation Of Lymphocyte Activation Negative Regulation Of Signaling Regulation Of Cell Activation Immune Response Regulation Of Immune System Process Positive Regulation Of Immune System Process Regulation Of Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Immune System Process Positive Regulation Of Cell Activation Regulation Of Signaling Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Innate Immune Response Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of T Cell Activation Positive Regulation Of Immune Response Signaling Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation T Cell Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Lymphocyte Activation Defense Response Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of T Cell Proliferation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Regulation Of Lymphocyte Differentiation Negative Regulation Of Leukocyte Activation Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Dephosphorylation Regulation Of B Cell Differentiation	Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process Protein Metabolic Process Proteolysis Protein Polyubiquitination Catabolic Process Protein K48-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Metabolic Process Protein K63-linked Ubiquitination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Signaling Protein Monoubiquitination Regulation Of Type I Interferon Production Negative Regulation Of Cytokine Production Negative Regulation Of Type I Interferon Production Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Viral Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Signal Transduction Negative Regulation Of Viral Release From Host Cell Cellular Response To Stimulus Regulation Of Viral Release From Host Cell Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Organic Substance Apoptotic Process Response To Stimulus Programmed Cell Death Regulation Of Cytokine Production Regulation Of Protein Ubiquitination Regulation Of Cellular Protein Metabolic Process Cell Death Regulation Of Kinase Activity Death Cellular Response To Cytokine Stimulus
Tagcloud ?		action clonal clone contrasts differentiate divisions enforced evident flk2 interfered leukemic lif m1 macrophage morphologic overcame parental perturbed physiologic renewal renewing rescued responsiveness satisfies stimulating striking suppression unstimulated	btbr c57blks db dba diabesity dissection hlbomdife hllt hyperglycaemia ifi202b inbred introgression jngj lean lep lepr lisch nzo ob obesity outcross pctp positional sorcs1 tallyho tbc1d1 tomosyn zealand zfp69
Tagcloud (Difference) ?		action clonal clone contrasts differentiate divisions enforced evident flk2 interfered leukemic lif m1 macrophage morphologic overcame parental perturbed physiologic renewal renewing rescued responsiveness satisfies stimulating striking suppression unstimulated	btbr c57blks db dba diabesity dissection hlbomdife hllt hyperglycaemia ifi202b inbred introgression jngj lean lep lepr lisch nzo ob obesity outcross pctp positional sorcs1 tallyho tbc1d1 tomosyn zealand zfp69
Tagcloud (Intersection) ?