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FLT3 and FLT3LG
Number of citations of the paper that reports this interaction (PubMedID
7505204
)
0
Data Source:
HPRD
(in vivo)
FLT3
FLT3LG
Description
fms related receptor tyrosine kinase 3
fms related receptor tyrosine kinase 3 ligand
Image
GO Annotations
Cellular Component
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Plasma Membrane
Endosome Membrane
Membrane
Protein-containing Complex
Receptor Complex
Extracellular Region
Extracellular Space
Cytosol
Plasma Membrane
Cell Surface
Membrane
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Transmembrane Signaling Receptor Activity
Cytokine Receptor Activity
Vascular Endothelial Growth Factor Receptor Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Growth Factor Binding
Nuclear Glucocorticoid Receptor Binding
Protein-containing Complex Binding
Phosphatidylinositol 3-kinase Activator Activity
Signaling Receptor Binding
Cytokine Activity
Protein Binding
Receptor Tyrosine Kinase Binding
Biological Process
Leukocyte Homeostasis
Myeloid Progenitor Cell Differentiation
Pro-B Cell Differentiation
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Macromolecule Metabolic Process
Cell Migration
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Hemopoiesis
B Cell Differentiation
Common Myeloid Progenitor Cell Proliferation
Vascular Endothelial Growth Factor Signaling Pathway
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Regulation Of Apoptotic Process
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Lymphocyte Proliferation
Protein Autophosphorylation
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cellular Response To Cytokine Stimulus
Cellular Response To Glucocorticoid Stimulus
Dendritic Cell Differentiation
Liver Regeneration
Signal Transduction
Positive Regulation Of Cell Population Proliferation
B Cell Differentiation
Positive Regulation Of Natural Killer Cell Proliferation
Embryonic Hemopoiesis
Dendritic Cell Differentiation
Pathways
PI3K Cascade
PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
FLT3 Signaling
FLT3 Signaling
STAT5 Activation
FLT3 mutants bind TKIs
STAT5 activation downstream of FLT3 ITD mutants
KW2449-resistant FLT3 mutants
semaxanib-resistant FLT3 mutants
crenolanib-resistant FLT3 mutants
gilteritinib-resistant FLT3 mutants
lestaurtinib-resistant FLT3 mutants
midostaurin-resistant FLT3 mutants
pexidartinib-resistant FLT3 mutants
ponatinib-resistant FLT3 mutants
quizartinib-resistant FLT3 mutants
sorafenib-resistant FLT3 mutants
sunitinib-resistant FLT3 mutants
tandutinib-resistant FLT3 mutants
linifanib-resistant FLT3 mutants
tamatinib-resistant FLT3 mutants
Signaling by FLT3 ITD and TKD mutants
Signaling by FLT3 ITD and TKD mutants
Negative regulation of FLT3
FLT3 signaling through SRC family kinases
FLT3 signaling through SRC family kinases
FLT3 signaling by CBL mutants
PI3K Cascade
PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
FLT3 Signaling
FLT3 Signaling
STAT5 Activation
Negative regulation of FLT3
FLT3 signaling through SRC family kinases
FLT3 signaling through SRC family kinases
FLT3 signaling by CBL mutants
Drugs
Sorafenib
Sunitinib
XL999
Tandutinib
Linifanib
Lestaurtinib
Midostaurin
Ponatinib
Nintedanib
Pacritinib
Tivozanib
Fostamatinib
Gilteritinib
Brigatinib
Fedratinib
Amuvatinib
Quizartinib
Pexidartinib
Pralsetinib
Diseases
Acute myeloid leukemia (AML)
GWAS
Apolipoprotein A1 levels (
32203549
)
Autoimmune thyroid disease (
32581359
)
Basophil count (
32888494
)
Body mass index (
25673413
29273807
)
Body size at age 10 (
32376654
)
Granulocyte count (
27863252
)
Granulocyte percentage of myeloid white cells (
27863252
)
HDL cholesterol levels (
32203549
)
Lymphocyte count (
32888494
)
Lymphocyte percentage of white cells (
27863252
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Medication use (thyroid preparations) (
31015401
)
Monocyte count (
29403010
32888494
27863252
)
Monocyte percentage of white cells (
32888494
27863252
)
Myeloid white cell count (
27863252
)
Neutrophil count (
32888494
27863252
)
Neutrophil percentage of white cells (
32888494
)
Non-albumin protein levels (
29403010
)
Pancreatic cancer (
25086665
)
Plateletcrit (
32888494
)
Psoriasis (
25854761
)
Rapid automised naming of digits (
30741946
)
Serum total protein levels (
29403010
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
Tourette syndrome (
30818990
)
White blood cell count (
27863252
32888494
)
White blood cell count (monocyte) (
28158719
)
Monocyte percentage of white cells (
32888494
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
31624269
)
Interacting Genes
18 interacting genes:
CBL
CBLB
CTNNB1
ERBB2
FIZ1
FLT3LG
GRB2
IKBKG
INPP5D
NCK1
PTPN11
PTPN12
PTPN6
SH3BP2
SLA
SOCS1
SRC
UBE2L6
5 interacting genes:
FLT3
KITLG
KRTAP5-9
PFN2
S100A6
Entrez ID
2322
2323
HPRD ID
00635
02477
Ensembl ID
ENSG00000122025
ENSG00000090554
Uniprot IDs
P36888
B7ZLY4
P49771
PDB IDs
1RJB
3QS7
3QS9
4RT7
4XUF
5X02
6IL3
6JQR
7QDP
7ZV9
8XB1
1ETE
3QS7
3QS9
7NBI
7QDP
7ZV9
Enriched GO Terms of Interacting Partners
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Phosphotyrosine Residue Binding
Receptor Tyrosine Kinase Binding
Regulation Of Lymphocyte Activation
Ephrin Receptor Binding
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Cell Activation
ERBB Signaling Pathway
Negative Regulation Of Immune System Process
Regulation Of Mononuclear Cell Proliferation
Regulation Of T Cell Activation
Regulation Of Leukocyte Proliferation
Cellular Response To Growth Factor Stimulus
SH3 Domain Binding
Response To Growth Factor
Negative Regulation Of Leukocyte Activation
Regulation Of MAPK Cascade
Positive Regulation Of Lymphocyte Activation
Negative Regulation Of Cell Activation
Regulation Of Cell-cell Adhesion
Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Leukocyte Cell-cell Adhesion
Leukocyte Activation
Positive Regulation Of Cell Activation
Immune System Process
Antigen Receptor-mediated Signaling Pathway
Negative Regulation Of Neutrophil Activation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Negative Regulation Of Lymphocyte Activation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Negative Regulation Of Lymphocyte Proliferation
Negative Regulation Of Mononuclear Cell Proliferation
Cell Activation
Regulation Of T Cell Proliferation
Negative Regulation Of Leukocyte Proliferation
Positive Regulation Of Cell Adhesion
Positive Regulation Of Cell-cell Adhesion
Regulation Of Neutrophil Activation
T Cell Receptor Signaling Pathway
T Cell Costimulation
Non-membrane Spanning Protein Tyrosine Phosphatase Activity
Neutrophil Activation Involved In Immune Response
Immune Response-activating Signaling Pathway
Regulation Of Signal Transduction
Peptidyl-tyrosine Phosphorylation
Regulation Of T Cell Receptor Signaling Pathway
Regulation Of Immune System Process
Positive Regulation Of Immune System Process
Regulation Of Cell Adhesion
Positive Regulation Of Cell Population Proliferation
Lymphocyte Proliferation
Leukocyte Proliferation
Hematopoietic Progenitor Cell Differentiation
Vascular Endothelial Growth Factor Receptor Activity
Positive Regulation Of Phosphorylation
Common Myeloid Progenitor Cell Proliferation
Pro-B Cell Differentiation
Myeloid Progenitor Cell Differentiation
Mononuclear Cell Proliferation
Phosphatidylinositol 3-kinase Activator Activity
Hemopoiesis
Positive Regulation Of Protein Phosphorylation
Mast Cell Apoptotic Process
Regulation Of Melanocyte Differentiation
Positive Regulation Of Mast Cell Proliferation
Negative Regulation Of Mast Cell Apoptotic Process
Melanocyte Migration
Mast Cell Proliferation
Mast Cell Migration
Regulation Of Mast Cell Apoptotic Process
Positive Regulation Of Pigment Cell Differentiation
Positive Regulation Of Hematopoietic Progenitor Cell Differentiation
Stem Cell Factor Receptor Binding
Positive Regulation Of Melanocyte Differentiation
Presynaptic Actin Cytoskeleton Organization
Presynaptic Cytoskeleton Organization
Negative Regulation Of Ruffle Assembly
Positive Regulation Of Developmental Pigmentation
Regulation Of Mast Cell Proliferation
Positive Regulation Of Hematopoietic Stem Cell Proliferation
Lymphoid Progenitor Cell Differentiation
Positive Regulation Of Phosphate Metabolic Process
Modification Of Postsynaptic Actin Cytoskeleton
Monoatomic Ion Transmembrane Transporter Activity
Regulation Of Developmental Pigmentation
Tropomyosin Binding
Nuclear Glucocorticoid Receptor Binding
S100 Protein Binding
Leukocyte Differentiation
Positive Regulation Of Protein Modification Process
Myeloid Cell Apoptotic Process
Negative Regulation Of Epithelial Cell Migration
Regulation Of Protein Phosphorylation
Regulation Of Hematopoietic Stem Cell Proliferation
Ectopic Germ Cell Programmed Cell Death
Positive Regulation Of Ras Protein Signal Transduction
Vascular Endothelial Growth Factor Signaling Pathway
Regulation Of Phosphorylation
Modification Of Postsynaptic Structure
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Tagcloud (Intersection)
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