FLT3 and FLT3LG

Number of citations of the paper that reports this interaction (PMID 7505204)
59

Data Source:
HPRD (in vivo)

		FLT3	FLT3LG
Gene Name		fms-related tyrosine kinase 3	fms-related tyrosine kinase 3 ligand
Image
Gene Ontology Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Lumen Cytosol Integral Component Of Plasma Membrane External Side Of Plasma Membrane Protein Complex	Extracellular Space Membrane Integral Component Of Membrane Intrinsic Component Of External Side Of Plasma Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Cytokine Receptor Activity Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding ATP Binding Protein Complex Binding Glucocorticoid Receptor Binding Protein Homodimerization Activity Phosphatidylinositol 3-kinase Binding	Receptor Binding Cytokine Activity Receptor Tyrosine Kinase Binding Protein Homodimerization Activity
	Biological Process	Leukocyte Homeostasis Myeloid Progenitor Cell Differentiation Pro-B Cell Differentiation Pro-T Cell Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Organonitrogen Compound Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Hemopoiesis B Cell Differentiation Organ Regeneration Common Myeloid Progenitor Cell Proliferation Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of B Cell Differentiation Lymphocyte Proliferation Protein Autophosphorylation Cellular Response To Cytokine Stimulus Cellular Response To Glucocorticoid Stimulus Dendritic Cell Differentiation	Positive Regulation Of Protein Phosphorylation Signal Transduction Positive Regulation Of Cell Proliferation Lymphocyte Differentiation Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of Natural Killer Cell Differentiation Embryonic Hemopoiesis Positive Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Fusion
Pathways
Drugs		Sorafenib Sunitinib Ponatinib
Diseases
GWAS
Protein-Protein Interactions		14 interactors: CBL CBLB FIZ1 FLT3LG GRB2 IKBKG INPP5D NCK1 PTPN12 PTPN6 SH3BP2 SLA SOCS1 UBE2L6	3 interactors: FLT3 KITLG PFN2
Entrez ID		2322	2323
HPRD ID		00635	02477
Ensembl ID		ENSG00000122025	ENSG00000090554
Uniprot IDs		P36888	B7ZLY4 M0QYM9 P49771 Q05C96
PDB IDs		1RJB 3QS7 3QS9	1ETE 3QS7 3QS9
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Signal Transduction Regulation Of Lymphocyte Activation Negative Regulation Of Signaling Regulation Of Cell Activation Immune Response Regulation Of Immune System Process Positive Regulation Of Immune System Process Regulation Of Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Immune System Process Positive Regulation Of Cell Activation Regulation Of Signaling Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Innate Immune Response Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of T Cell Activation Positive Regulation Of Immune Response Signaling Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation T Cell Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Lymphocyte Activation Defense Response Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of T Cell Proliferation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Regulation Of Lymphocyte Differentiation Negative Regulation Of Leukocyte Activation Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Dephosphorylation Regulation Of B Cell Differentiation	Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of MAP Kinase Activity Pro-T Cell Differentiation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Common Myeloid Progenitor Cell Proliferation Negative Regulation Of Mast Cell Apoptotic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Mast Cell Apoptotic Process Pro-B Cell Differentiation Negative Regulation Of Ruffle Assembly Positive Regulation Of Mast Cell Proliferation Negative Regulation Of Immune System Process Regulation Of Protein Metabolic Process Negative Regulation Of B Cell Differentiation Positive Regulation Of MAPK Cascade Regulation Of Catalytic Activity Positive Regulation Of Melanocyte Differentiation Myeloid Progenitor Cell Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Melanocyte Differentiation Positive Regulation Of Pigment Cell Differentiation Lymphoid Progenitor Cell Differentiation Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Developmental Pigmentation Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of MAPK Cascade Hemopoiesis Negative Regulation Of Myeloid Cell Apoptotic Process Regulation Of Ruffle Assembly Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune System Development Regulation Of Developmental Pigmentation
Tagcloud ?		action clonal clone contrasts differentiate divisions enforced evident flk2 interfered leukemic lif m1 macrophage morphologic overcame parental perturbed physiologic renewal renewing rescued responsiveness satisfies stimulating striking suppression unstimulated
Tagcloud (Difference) ?		action clonal clone contrasts differentiate divisions enforced evident flk2 interfered leukemic lif m1 macrophage morphologic overcame parental perturbed physiologic renewal renewing rescued responsiveness satisfies stimulating striking suppression unstimulated
Tagcloud (Intersection) ?