FGR and WAS

Number of citations of the paper that reports this interaction (PMID 7565724)
56

Data Source:
HPRD (in vitro, in vivo)

		FGR	WAS
Gene Name		FGR proto-oncogene, Src family tyrosine kinase	Wiskott-Aldrich syndrome
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ruffle Membrane Extracellular Vesicular Exosome	Cytosol Cell-cell Junction Vesicle Membrane Actin Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Phosphotyrosine Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Immunoglobulin Receptor Binding Fc-gamma Receptor I Complex Binding	Actin Binding Small GTPase Regulator Activity Protein Binding SH3 Domain Binding Protein Kinase Binding Identical Protein Binding Phospholipase Binding
	Biological Process	Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Blood Coagulation Regulation Of Cell Shape Response To Virus Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Proliferation Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Regulation Of Innate Immune Response Regulation Of Protein Kinase Activity Protein Autophosphorylation Positive Regulation Of Cytokine Secretion Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Cellular Response To Peptide Hormone Stimulus	Protein Complex Assembly Defense Response Immune Response Blood Coagulation Actin Polymerization Or Depolymerization Epidermis Development Endosomal Transport Actin Filament Polymerization Actin Filament-based Movement Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis T Cell Activation Innate Immune Response Regulation Of Catalytic Activity T Cell Receptor Signaling Pathway Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		Platelet homeostasis Platelet sensitization by LDL Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation Innate Immune System	TCR signaling Generation of second messenger molecules Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		22 interactors: ARRB1 CBL CCR3 CSK DAB2 DOK1 ERBB2 FASLG HCLS1 IKBKG INPP5D KHDRBS1 NR1I2 PTK2 SLAMF1 SNCA SRC STAT3 SYK VDR WAS YWHAQ	53 interactors: ABI3 ACTC1 APBB1 APPBP2 ARHGAP1 ARHGEF7 ARPC1B ARPC2 ARPC3 BAIAP2L1 BTK C5AR1 CDC42 CIB1 CRKL CSNK2A1 CSNK2A2 DLG1 ENAH EVL FCHSD2 FGR FYB FYN GAS7 GRB2 HCK HCLS1 ITK ITSN2 LCK LCP2 NCK1 NCK2 NCKIPSD PIK3R1 PLCG1 PRPF40A PSTPIP1 PTPN12 RAC1 RGS14 RHOJ SORBS2 SRC TCERG1 TEC TNK2 TRIP10 VASP WBP4 WIPF1 WIPF2
Entrez ID		2268	7454
HPRD ID		01288	02314
Ensembl ID		ENSG00000000938	ENSG00000015285
Uniprot IDs		P09769 P78453	P42768
PDB IDs			1CEE 1EJ5 1T84 2A3Z 2K42 2OT0
Enriched GO Terms of Interacting Partners?		Signaling Cell Communication Positive Regulation Of Signal Transduction Signal Transduction Cellular Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Response To Stimulus Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Response To Organic Substance Regulation Of Endocytosis Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Cellular Response To Organic Substance Regulation Of Cell Proliferation Positive Regulation Of Phosphorylation Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Regulation Of Tissue Remodeling Positive Regulation Of Cellular Biosynthetic Process Regulation Of Intracellular Transport Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cellular Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Kinase Activity Immune Response-regulating Signaling Pathway Immune System Process Positive Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Transport Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transferase Activity Regulation Of Catalytic Activity Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Bone Resorption Positive Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process	Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Immune System Process Locomotion Axon Guidance Regulation Of Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Actin Filament Organization Innate Immune Response Chemotaxis Positive Regulation Of Actin Filament Polymerization Axonogenesis Neuron Projection Morphogenesis Immune Response Positive Regulation Of Protein Polymerization Enzyme Linked Receptor Protein Signaling Pathway Axon Development Actin Cytoskeleton Organization Cell Morphogenesis Involved In Neuron Differentiation Phagocytosis Positive Regulation Of Protein Complex Assembly Cell Morphogenesis Involved In Differentiation Cytoskeleton Organization Actin Filament-based Process Regulation Of Actin Filament Polymerization Cell Surface Receptor Signaling Pathway Endocytosis Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Protein Complex Assembly Regulation Of Actin Filament Length Neuron Projection Development Regulation Of Cellular Component Organization Antigen Receptor-mediated Signaling Pathway Cell Projection Morphogenesis Cell Part Morphogenesis Response To External Stimulus Signal Transduction T Cell Receptor Signaling Pathway Signaling
Tagcloud ?		colocalization confocal edge electrophoretic fyn hck incompletely isre jak jak1 jak3 lyn masses migrating mobility p59 plasminogen polarization ptk ptks src stat1 supershift tyk2 upa upar urokinase utilizes vsmc
Tagcloud (Difference) ?		colocalization confocal edge electrophoretic fyn hck incompletely isre jak jak1 jak3 lyn masses migrating mobility p59 plasminogen polarization ptk ptks src stat1 supershift tyk2 upa upar urokinase utilizes vsmc
Tagcloud (Intersection) ?