FGR and SLAMF1

Number of citations of the paper that reports this interaction (PMID 10229804)
10

Data Source:
HPRD (in vitro, in vivo)

		FGR	SLAMF1
Gene Name		FGR proto-oncogene, Src family tyrosine kinase	signaling lymphocytic activation molecule family member 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ruffle Membrane Extracellular Vesicular Exosome	External Side Of Plasma Membrane Integral Component Of Membrane Phagocytic Vesicle Extracellular Vesicular Exosome
	Molecular Function	Phosphotyrosine Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Immunoglobulin Receptor Binding Fc-gamma Receptor I Complex Binding	Antigen Binding Transmembrane Signaling Receptor Activity Protein Binding
	Biological Process	Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Blood Coagulation Regulation Of Cell Shape Response To Virus Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Proliferation Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Regulation Of Innate Immune Response Regulation Of Protein Kinase Activity Protein Autophosphorylation Positive Regulation Of Cytokine Secretion Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Cellular Response To Peptide Hormone Stimulus	Signal Transduction Positive Regulation Of Cell Proliferation Viral Process Regulation Of Vesicle Fusion Lymphocyte Activation Regulation Of Catalytic Activity
Pathways		Platelet homeostasis Platelet sensitization by LDL Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation Innate Immune System
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Schizophrenia (treatment refractory) ( 22479419)
Protein-Protein Interactions		22 interactors: ARRB1 CBL CCR3 CSK DAB2 DOK1 ERBB2 FASLG HCLS1 IKBKG INPP5D KHDRBS1 NR1I2 PTK2 SLAMF1 SNCA SRC STAT3 SYK VDR WAS YWHAQ	5 interactors: FGR FYN PTPN11 SH2D1A SH2D1B
Entrez ID		2268	6504
HPRD ID		01288	04603
Ensembl ID		ENSG00000000938	ENSG00000117090
Uniprot IDs		P09769 P78453	Q13291
PDB IDs			1D4T 1D4W 1KA6 1KA7 1M27 2DZF 2IE9 2IFL 2IG5
Enriched GO Terms of Interacting Partners?		Signaling Cell Communication Positive Regulation Of Signal Transduction Signal Transduction Cellular Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Response To Stimulus Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Response To Organic Substance Regulation Of Endocytosis Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Cellular Response To Organic Substance Regulation Of Cell Proliferation Positive Regulation Of Phosphorylation Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Regulation Of Tissue Remodeling Positive Regulation Of Cellular Biosynthetic Process Regulation Of Intracellular Transport Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cellular Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Kinase Activity Immune Response-regulating Signaling Pathway Immune System Process Positive Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Transport Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transferase Activity Regulation Of Catalytic Activity Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Bone Resorption Positive Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process	Regulation Of Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Immune Response Regulation Of Immune System Process Positive Regulation Of Immune Response Positive Regulation Of Natural Killer Cell Mediated Immunity Immune System Process Regulation Of Natural Killer Cell Mediated Immunity Fc Receptor Signaling Pathway Positive Regulation Of Cell Activation Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Peptidyl-tyrosine Autophosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Defense Response Blood Coagulation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Hemostasis Response To Peptide Hormone Cellular Response To Organonitrogen Compound Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Response To Peptide T Cell Costimulation Regulation Of Phosphatidylinositol 3-kinase Signaling Cellular Response To Hormone Stimulus Regulation Of Body Fluid Levels Wound Healing Ephrin Receptor Signaling Pathway Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Integrin-mediated Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Protein Localization Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Response To Organonitrogen Compound Regulation Of Cell Shape Cell Migration Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cell Motility
Tagcloud ?		colocalization confocal edge electrophoretic fyn hck incompletely isre jak jak1 jak3 lyn masses migrating mobility p59 plasminogen polarization ptk ptks src stat1 supershift tyk2 upa upar urokinase utilizes vsmc	allelic c57bl cd4 cd8 congenic contrary copy enhancement hcd2 immature inversely isoform minigene nkrp1b nkt nkt1 nod numbers paradoxically selection subcongenic tcr tg thymic thymocytes transgene transgenic transgenically
Tagcloud (Difference) ?		colocalization confocal edge electrophoretic fyn hck incompletely isre jak jak1 jak3 lyn masses migrating mobility p59 plasminogen polarization ptk ptks src stat1 supershift tyk2 upa upar urokinase utilizes vsmc	allelic c57bl cd4 cd8 congenic contrary copy enhancement hcd2 immature inversely isoform minigene nkrp1b nkt nkt1 nod numbers paradoxically selection subcongenic tcr tg thymic thymocytes transgene transgenic transgenically
Tagcloud (Intersection) ?