FCGR2B and INPPL1

Number of citations: 0 (PubMedID 10789675)
Data Source: HPRD (in vitro, in vivo)

		FCGR2B	INPPL1
Name		Fc gamma receptor IIb	inositol polyphosphate phosphatase like 1
Structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Dendritic Spine Cell Body	Spindle Pole Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Basal Plasma Membrane Membrane Nuclear Speck Lamellipodium Filopodium Cell Projection
	Molecular Function	Amyloid-beta Binding Protein Binding IgG Receptor Activity Low-affinity IgG Receptor Activity IgG Binding Protein-containing Complex Binding	Actin Binding Inositol-polyphosphate 5-phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity SH3 Domain Binding Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity SH2 Domain Binding
	Biological Process	Antibody-dependent Cellular Cytotoxicity Negative Regulation Of Type I Hypersensitivity Negative Regulation Of Antibody-dependent Cellular Cytotoxicity Negative Regulation Of Cytokine Production Immune Effector Process Follicular Dendritic Cell Activation Mature B Cell Differentiation Involved In Immune Response Follicular B Cell Differentiation Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Regulation Of B Cell Antigen Processing And Presentation Negative Regulation Of Immunoglobulin Production Regulation Of Immune System Process Regulation Of Adaptive Immune Response Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Receptor-mediated Endocytosis Phagocytosis Phagocytosis, Engulfment Defense Response Inflammatory Response Cell Surface Receptor Signaling Pathway Response To Bacterium Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cerebellum Development Negative Regulation Of B Cell Proliferation Negative Regulation Of Interleukin-10 Production Positive Regulation Of Tumor Necrosis Factor Production Fc-gamma Receptor Signaling Pathway Negative Regulation Of Macrophage Activation Negative Regulation Of Cytotoxic T Cell Degranulation Regulation Of Innate Immune Response Mast Cell Activation Positive Regulation Of JNK Cascade Negative Regulation Of Phagocytosis Positive Regulation Of Phagocytosis Negative Regulation Of Immune Response Negative Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of B Cell Activation Cellular Response To Molecule Of Bacterial Origin Regulation Of Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of Neutrophil Activation Regulation Of Dendritic Spine Maintenance Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Amyloid-beta Positive Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Dendritic Cell Differentiation	Establishment Of Mitotic Spindle Orientation Endochondral Ossification Immune System Process Glucose Metabolic Process Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Endocytosis Apoptotic Process Actin Filament Organization Cell Adhesion Negative Regulation Of Cell Population Proliferation Post-embryonic Development Gene Expression Negative Regulation Of Gene Expression Response To Insulin Regulation Of Protein Localization Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol Dephosphorylation Regulation Of Immune Response ERK1 And ERK2 Cascade Ruffle Assembly Regulation Of Actin Filament Organization
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Interleukin receptor SHC signaling Signaling by CSF1 (M-CSF) in myeloid cells
Drugs		Etanercept Human immunoglobulin G Abciximab Tositumomab Alemtuzumab Antithymocyte immunoglobulin (rabbit) Palivizumab Daclizumab Bevacizumab Sarilumab	None
Diseases		Systemic lupus erythematosus	None
GWAS		Alanine aminotransferase levels ( 34315874 ) Apolipoprotein A1 levels ( 32203549 ) Aspartate aminotransferase levels ( 34315874 33547301 ) Basophil count ( 32888494 ) Basophil percentage of white cells ( 32888494 ) Birth weight ( 27680694 31043758 ) Blood protein levels ( 30072576 ) Granulocyte count ( 27863252 ) HDL cholesterol levels ( 32203549 ) Hemoglobin ( 32888494 ) Hemoglobin concentration ( 27863252 ) IgG levels ( 28628107 ) Inflammatory bowel disease ( 28067908 23128233 ) Lipid metabolism phenotypes ( 22286219 ) Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 27863252 32888494 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 27863252 32888494 ) Offspring birth weight ( 31043758 ) Red blood cell count ( 32888494 ) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576 ) Rheumatoid arthritis ( 30423114 ) Serum total protein levels ( 29403010 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) Systemic lupus erythematosus ( 26502338 ) Ulcerative colitis ( 21297633 28067908 ) White blood cell count ( 32888494 27863252 )	Heart rate response to recovery post exercise (10 sec) ( 29497042 )
Novel Interactors		7 novel interactors: AP3B1 FCER1G FCGR2A HSPA6 MGST3 MRTFB ZBTB18	3 novel interactors: DRD2 HYOU1 KMT2A
Interacting Genes		15 interacting genes: APCS BLK CRP ERG28 GAB1 GRB2 INPP5D INPPL1 LY6E LYN MAPK1 MAPK3 PRKCA PTPN11 PTPN6	23 interacting genes: ABL1 AR ARAP3 BCAR1 CBL CD4 CSF1R EGFR ERBB2 ERBB3 ERBB4 FCGR2B FLNC GAB1 HID1 LNCAROD MET PLEK2 SHC1 SORBS1 SORBS3 SRC UBC
Entrez ID		2213	3636
HPRD ID		06849	02900
Ensembl ID		ENSG00000072694	ENSG00000165458
Uniprot IDs		P31994	O15357
PDB IDs		2FCB 3WJJ 5OCC	2K4P 2KSO 2MK2 3NR8 4A9C 5OKM 5OKN 5OKO 5OKP 6SQU 6SRR
GO Terms Enriched among Interactors		Regulation Of Immune System Process Regulation Of Immune Response Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Immune System Process B Cell Receptor Signaling Pathway Immune Response-activating Signaling Pathway Positive Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Effector Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Defense Response Antigen Receptor-mediated Signaling Pathway Activation Of Immune Response Regulation Of Leukocyte Proliferation ERBB Signaling Pathway Regulation Of Cell Activation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Regulation Of Multicellular Organismal Process Negative Regulation Of Immune System Process Bergmann Glial Cell Differentiation SH3 Domain Binding T Cell Costimulation Lymphocyte Mediated Immunity Response To Stress Neutrophil Activation Involved In Immune Response Peptidyl-tyrosine Phosphorylation Innate Immune Response Positive Regulation Of Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Leukocyte Mediated Immunity Cell Surface Receptor Signaling Pathway Glial Cell Development Response To External Biotic Stimulus Schwann Cell Development Positive Regulation Of Multicellular Organismal Process Regulation Of Cell-cell Adhesion Defense Response To Symbiont Negative Regulation Of Lymphocyte Activation Defense Response Leukocyte Mediated Cytotoxicity Regulation Of Lymphocyte Activation Defense Response To Other Organism Insulin Receptor Signaling Pathway Positive Regulation Of Lymphocyte Activation Protein Phosphorylation Intracellular Signal Transduction Regulation Of Lymphocyte Mediated Immunity	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of MAPK Cascade Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Protein Tyrosine Kinase Activity Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus ERBB2 Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Response To Growth Factor Negative Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Focal Adhesion Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Negative Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Apoptotic Process Signal Transduction Basal Plasma Membrane Ephrin Receptor Binding Plasma Membrane Animal Organ Development Regulation Of Cellular Component Organization Receptor Complex Positive Regulation Of Cell Population Proliferation Protein Kinase Activity Positive Regulation Of Macromolecule Biosynthetic Process Neuron Differentiation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Biosynthetic Process Positive Regulation Of Protein Phosphorylation Regulation Of Cell Population Proliferation Positive Regulation Of Phosphorylation Protein Tyrosine Kinase Activator Activity Shc-EGFR Complex ERBB3:ERBB2 Complex Kinase Activity Intracellular Signal Transduction