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FCGR2B and LY6E
Number of citations of the paper that reports this interaction (PubMedID
11576217
)
45
Data Source:
HPRD
(in vivo)
FCGR2B
LY6E
Description
Fc gamma receptor IIb
lymphocyte antigen 6 family member E
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
External Side Of Plasma Membrane
Membrane
Dendritic Spine
Cell Body
Extracellular Region
Plasma Membrane
Membrane
Synapse
Side Of Membrane
Molecular Function
Amyloid-beta Binding
Protein Binding
IgG Receptor Activity
Low-affinity IgG Receptor Activity
IgG Binding
Protein-containing Complex Binding
Protein Binding
Acetylcholine Receptor Inhibitor Activity
Acetylcholine Receptor Binding
Biological Process
Antibody-dependent Cellular Cytotoxicity
Negative Regulation Of Type I Hypersensitivity
Negative Regulation Of Antibody-dependent Cellular Cytotoxicity
Negative Regulation Of Cytokine Production
Immune Effector Process
Follicular Dendritic Cell Activation
Mature B Cell Differentiation Involved In Immune Response
Follicular B Cell Differentiation
Immune Complex Clearance By Monocytes And Macrophages
Negative Regulation Of Dendritic Cell Antigen Processing And Presentation
Regulation Of B Cell Antigen Processing And Presentation
Negative Regulation Of Immunoglobulin Production
Regulation Of Immune System Process
Regulation Of Adaptive Immune Response
Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus
Positive Regulation Of Humoral Immune Response
Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Receptor-mediated Endocytosis
Phagocytosis
Phagocytosis, Engulfment
Defense Response
Inflammatory Response
Cell Surface Receptor Signaling Pathway
Response To Bacterium
Immunoglobulin Mediated Immune Response
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Cerebellum Development
Negative Regulation Of B Cell Proliferation
Negative Regulation Of Interleukin-10 Production
Positive Regulation Of Tumor Necrosis Factor Production
Fc-gamma Receptor Signaling Pathway
Negative Regulation Of Macrophage Activation
Negative Regulation Of Cytotoxic T Cell Degranulation
Regulation Of Innate Immune Response
Mast Cell Activation
Positive Regulation Of JNK Cascade
Negative Regulation Of Phagocytosis
Positive Regulation Of Phagocytosis
Negative Regulation Of Immune Response
Negative Regulation Of B Cell Receptor Signaling Pathway
Negative Regulation Of B Cell Activation
Cellular Response To Molecule Of Bacterial Origin
Regulation Of Immune Complex Clearance By Monocytes And Macrophages
Negative Regulation Of Neutrophil Activation
Regulation Of Dendritic Spine Maintenance
Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Cellular Response To Amyloid-beta
Positive Regulation Of Response To Endoplasmic Reticulum Stress
Negative Regulation Of Dendritic Cell Differentiation
Cell Surface Receptor Signaling Pathway
Host-mediated Suppression Of Symbiont Invasion
Acetylcholine Receptor Signaling Pathway
Pathways
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Post-translational modification: synthesis of GPI-anchored proteins
Drugs
Etanercept
Human immunoglobulin G
Abciximab
Tositumomab
Alemtuzumab
Antithymocyte immunoglobulin (rabbit)
Palivizumab
Daclizumab
Bevacizumab
Sarilumab
Diseases
Systemic lupus erythematosus
GWAS
Alanine aminotransferase levels (
34315874
)
Apolipoprotein A1 levels (
32203549
)
Aspartate aminotransferase levels (
34315874
33547301
)
Basophil count (
32888494
)
Basophil percentage of white cells (
32888494
)
Birth weight (
27680694
31043758
)
Blood protein levels (
30072576
)
Granulocyte count (
27863252
)
HDL cholesterol levels (
32203549
)
Hemoglobin (
32888494
)
Hemoglobin concentration (
27863252
)
IgG levels (
28628107
)
Inflammatory bowel disease (
28067908
23128233
)
Lipid metabolism phenotypes (
22286219
)
Monocyte count (
32888494
)
Monocyte percentage of white cells (
27863252
32888494
)
Myeloid white cell count (
27863252
)
Neutrophil count (
27863252
32888494
)
Offspring birth weight (
31043758
)
Red blood cell count (
32888494
)
Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis (
26980576
)
Rheumatoid arthritis (
30423114
)
Serum total protein levels (
29403010
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
Systemic lupus erythematosus (
26502338
)
Ulcerative colitis (
21297633
28067908
)
White blood cell count (
32888494
27863252
)
Interacting Genes
15 interacting genes:
APCS
BLK
CRP
ERG28
GAB1
GRB2
INPP5D
INPPL1
LY6E
LYN
MAPK1
MAPK3
PRKCA
PTPN11
PTPN6
6 interacting genes:
CD247
FCGR2B
MFSD6
TMEM140
TMEM19
TRARG1
Entrez ID
2213
4061
HPRD ID
06849
03227
Ensembl ID
ENSG00000072694
ENSG00000160932
Uniprot IDs
P31994
Q16553
PDB IDs
2FCB
3WJJ
5OCC
Enriched GO Terms of Interacting Partners
?
Regulation Of Immune System Process
Regulation Of Immune Response
Immune Response-regulating Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Phosphotyrosine Residue Binding
Immune System Process
B Cell Receptor Signaling Pathway
Immune Response-activating Signaling Pathway
Positive Regulation Of Immune System Process
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Effector Process
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Defense Response
Antigen Receptor-mediated Signaling Pathway
Activation Of Immune Response
Regulation Of Leukocyte Proliferation
ERBB Signaling Pathway
Regulation Of Cell Activation
Negative Regulation Of Mononuclear Cell Proliferation
Negative Regulation Of Leukocyte Proliferation
Regulation Of Multicellular Organismal Process
Negative Regulation Of Immune System Process
Bergmann Glial Cell Differentiation
SH3 Domain Binding
T Cell Costimulation
Lymphocyte Mediated Immunity
Response To Stress
Neutrophil Activation Involved In Immune Response
Peptidyl-tyrosine Phosphorylation
Innate Immune Response
Positive Regulation Of Immune Response
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Leukocyte Mediated Immunity
Cell Surface Receptor Signaling Pathway
Glial Cell Development
Response To External Biotic Stimulus
Schwann Cell Development
Positive Regulation Of Multicellular Organismal Process
Regulation Of Cell-cell Adhesion
Defense Response To Symbiont
Negative Regulation Of Lymphocyte Activation
Defense Response
Leukocyte Mediated Cytotoxicity
Regulation Of Lymphocyte Activation
Defense Response To Other Organism
Insulin Receptor Signaling Pathway
Positive Regulation Of Lymphocyte Activation
Protein Phosphorylation
Intracellular Signal Transduction
Regulation Of Lymphocyte Mediated Immunity
IgG Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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