INHBC and ACVR2A

Number of citations: 0 (PubMedID 12651901)
Data Source: HPRD (in vivo)

		INHBC	ACVR2A
Name		inhibin subunit beta C	activin A receptor type 2A
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm Plasma Membrane Cell Surface Membrane Inhibin-betaglycan-ActRII Complex Receptor Complex Activin Receptor Complex
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Hormone Activity Growth Factor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Coreceptor Activity Kinase Activity Activin Receptor Activity, Type I Activin Receptor Activity, Type II Transferase Activity Activin Receptor Activity Growth Factor Binding PDZ Domain Binding Inhibin Binding Identical Protein Binding Metal Ion Binding Activin Binding BMP Receptor Activity
	Biological Process	Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway	Osteoblast Differentiation Gastrulation With Mouth Forming Second Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Spermatogenesis Determination Of Left/right Symmetry Pattern Specification Process Mesoderm Development Male Gonad Development Anterior/posterior Pattern Specification Regulation Of Signal Transduction Negative Regulation Of Ossification Positive Regulation Of Bone Mineralization BMP Signaling Pathway Developmental Process Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Sperm Ejaculation Penile Erection Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Development Sertoli Cell Proliferation Positive Regulation Of SMAD Protein Signal Transduction Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus
Pathways		Glycoprotein hormones	Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP TGFBR3 regulates activin signaling
Drugs		None	Sotatercept
GWAS		Apolipoprotein A1 levels ( 32203549 ) Aspartate aminotransferase levels ( 33547301 ) Asthma ( 31619474 ) Blood protein levels ( 30072576 ) Body mass index and HDL-C (pairwise) ( 33619380 ) Body mass index and triglycerides (pairwise) ( 33619380 ) Chronic kidney disease ( 29124443 ) Chronotype ( 30696823 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Fasting glucose ( 34059833 ) Glomerular filtration rate (creatinine) ( 26831199 ) Gout ( 33832965 ) HDL cholesterol levels ( 30698716 32203549 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Hemoglobin levels ( 32327693 ) Serum uric acid levels ( 30993211 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Urate levels ( 31985003 31578528 20884846 23263486 ) Urate levels in overweight individuals ( 25811787 )	Adult body size ( 32376654 ) Adventurousness ( 30643258 ) Arterial stiffness index ( 31235810 ) Asthma (adult onset) ( 31036433 ) Basophil count ( 32888494 ) Basophil percentage of granulocytes ( 27863252 ) Basophil percentage of white cells ( 27863252 ) Cerebrospinal T-tau levels ( 28247064 ) Diastolic blood pressure ( 30224653 ) Eosinophil count ( 32888494 ) Estimated glomerular filtration rate ( 31015462 ) Feeling hurt ( 29500382 ) Feeling miserable ( 29500382 ) Feeling nervous ( 29500382 ) Feeling tense ( 29500382 ) General risk tolerance (MTAG) ( 30643258 ) Glomerular filtration rate (creatinine) ( 26831199 ) Haemorrhoidal disease ( 33888516 ) HDL cholesterol levels ( 32203549 ) High myopia ( 31816047 ) Loneliness (MTAG) ( 29970889 ) Neutrophil percentage of granulocytes ( 27863252 ) Photic sneeze reflex ( 30899065 ) Refractive error ( 32231278 ) Response to statin therapy ( 20339536 ) Retinal detachment or retinal break ( 31816047 ) Urate levels ( 31985003 23263486 ) White blood cell count (basophil) ( 27863252 )
Novel Interactors		None recorded	1 novel interactors: BACE2
Interacting Genes		6 interacting genes: ACVR1 ACVR1B ACVR2A ACVR2B INHBA INHBB	23 interacting genes: ACVRL1 BMP10 BMP2 BMP4 BMP6 BMP7 CRIPTO DAXX DYNLT4 ENG ERBIN GDF2 GDF5 GDF9 IGSF1 INHBA INHBB INHBC MAGI2 NODAL PRSS50 SYNJ2BP TGFBR3
Entrez ID		3626	92
HPRD ID		03136	00025
Ensembl ID		ENSG00000175189	ENSG00000121989
Uniprot IDs		P55103	P27037
PDB IDs		Not available	3Q4T 3SOC 4ASX 5NH3 7U5P
GO Terms Enriched among Interactors		Activin Receptor Signaling Pathway Activin Receptor Complex Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Activin Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Activin Receptor Signaling Pathway Activin Receptor Activity Positive Regulation Of Activin Receptor Signaling Pathway Growth Factor Binding Activin Receptor Activity, Type I Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Gastrulation With Mouth Forming Second Regulation Of Ossification Positive Regulation Of Ovulation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Negative Regulation Of Ossification Activin Receptor Activity, Type II Negative Regulation Of Follicle-stimulating Hormone Secretion Gastrulation Positive Regulation Of Biomineral Tissue Development Regulation Of Erythrocyte Differentiation Positive Regulation Of Ossification Inhibin Binding Positive Regulation Of Signal Transduction Mesoderm Development Positive Regulation Of Multicellular Organismal Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Osteoblast Differentiation Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Response To Growth Factor Regulation Of Bone Mineralization Positive Regulation Of Reproductive Process Positive Regulation Of Cell Differentiation BMP Signaling Pathway Cell Surface Receptor Signaling Pathway BMP Receptor Activity Negative Regulation Of Gonadotropin Secretion Determination Of Bilateral Symmetry Determination Of Left/right Symmetry Odontogenesis Protein Serine/threonine Kinase Activity	Positive Regulation Of SMAD Protein Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of SMAD Protein Signal Transduction Growth Factor Activity Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Cytokine Activity Activin Receptor Signaling Pathway Positive Regulation Of Cartilage Development Cell Surface Receptor Signaling Pathway Cellular Response To BMP Stimulus Regulation Of Cartilage Development Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Heart Development Extracellular Space Cellular Response To Growth Factor Stimulus Signal Transduction Response To Growth Factor Positive Regulation Of Epithelial Cell Differentiation Regulation Of Intracellular Signal Transduction Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Animal Organ Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Development Negative Regulation Of Locomotion Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Epithelial Cell Proliferation Regulation Of Epithelial Cell Proliferation Regulation Of Signal Transduction Regulation Of Cell Migration Epithelial To Mesenchymal Transition Regulation Of Epithelial Cell Differentiation BMP Receptor Binding Positive Regulation Of BMP Signaling Pathway Tissue Morphogenesis Enzyme Activator Complex Regulation Of Cell Motility Positive Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Differentiation Regulation Of Locomotion Transforming Growth Factor Beta Receptor Signaling Pathway Cartilage Development Mesenchymal Cell Differentiation