INHBC and ACVR2B

Number of citations of the paper that reports this interaction (PubMedID 12651901)
0

Data Source:
HPRD (in vivo)

		INHBC	ACVR2B
Description		inhibin subunit beta C	activin A receptor type 2B
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm Plasma Membrane Membrane Protein-containing Complex Receptor Complex Activin Receptor Complex
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Hormone Activity Growth Factor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type II Transferase Activity Activin Receptor Activity Kinase Activator Activity Growth Factor Binding Metal Ion Binding Activin Binding
	Biological Process	Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Gastrulation With Mouth Forming Second Kidney Development Lymphangiogenesis Blood Vessel Remodeling Regulation Of DNA-templated Transcription Intracellular Iron Ion Homeostasis Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Determination Of Left/right Symmetry Pattern Specification Process Mesoderm Development Heart Development Response To Glucose Post-embryonic Development Anterior/posterior Pattern Specification Regulation Of Signal Transduction Insulin Secretion Negative Regulation Of Ossification Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Pancreas Development Developmental Process Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Organ Growth Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Osteoblast Differentiation Embryonic Foregut Morphogenesis Skeletal System Morphogenesis Roof Of Mouth Development Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye Trophoblast Cell Migration Cellular Response To Growth Factor Stimulus Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Adipose Tissue Development
Pathways		Glycoprotein hormones	Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP
Drugs
Diseases			Heterotaxy; Situs ambiguus
GWAS		Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Asthma ( 31619474) Blood protein levels ( 30072576) Body mass index and HDL-C (pairwise) ( 33619380) Body mass index and triglycerides (pairwise) ( 33619380) Chronic kidney disease ( 29124443) Chronotype ( 30696823) Estimated glomerular filtration rate in non-diabetics ( 31451708) Fasting glucose ( 34059833) Glomerular filtration rate (creatinine) ( 26831199) Gout ( 33832965) HDL cholesterol levels ( 30698716 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hemoglobin levels ( 32327693) Serum uric acid levels ( 30993211) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Urate levels ( 31985003 31578528 20884846 23263486) Urate levels in overweight individuals ( 25811787)	Bitter beverage consumption ( 31046077) Body size at age 10 ( 32376654) Estimated glomerular filtration rate ( 31015462 31152163) P wave duration ( 24850809)
Interacting Genes		6 interacting genes: ACVR1 ACVR1B ACVR2A ACVR2B INHBA INHBB	26 interacting genes: ACVR1B BMP10 BMP2 BMP7 CRIPTO DLG1 ERBIN FBXO7 GDF11 GDF2 GDF5 IGSF1 INHBA INHBB INHBC MSTN NHERF2 NODAL SCRIB SNTB1 SNX1 SNX2 SNX27 SNX6 SYNJ2BP TGFBRAP1
Entrez ID		3626	93
HPRD ID		03136	04106
Ensembl ID		ENSG00000175189	ENSG00000114739
Uniprot IDs		P55103	Q13705
PDB IDs			2H62 2QLU 4FAO 5NGV 5NHR 7MRZ 7OLY
Enriched GO Terms of Interacting Partners?		Activin Receptor Signaling Pathway Activin Receptor Complex Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Activin Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Activin Receptor Signaling Pathway Activin Receptor Activity Positive Regulation Of Activin Receptor Signaling Pathway Growth Factor Binding Activin Receptor Activity, Type I Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Gastrulation With Mouth Forming Second Regulation Of Ossification Positive Regulation Of Ovulation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Negative Regulation Of Ossification Activin Receptor Activity, Type II Negative Regulation Of Follicle-stimulating Hormone Secretion Gastrulation Positive Regulation Of Biomineral Tissue Development Regulation Of Erythrocyte Differentiation Positive Regulation Of Ossification Inhibin Binding Positive Regulation Of Signal Transduction Mesoderm Development Positive Regulation Of Multicellular Organismal Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Osteoblast Differentiation Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Response To Growth Factor Regulation Of Bone Mineralization Positive Regulation Of Reproductive Process Positive Regulation Of Cell Differentiation BMP Signaling Pathway Cell Surface Receptor Signaling Pathway BMP Receptor Activity Negative Regulation Of Gonadotropin Secretion Determination Of Bilateral Symmetry Determination Of Left/right Symmetry Odontogenesis Protein Serine/threonine Kinase Activity	Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Growth Factor Activity Activin Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cytokine Activity Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Cartilage Development Regulation Of Signaling Regulation Of Signal Transduction BMP Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Developmental Process Anatomical Structure Morphogenesis Retromer, Tubulation Complex Regulation Of Cell Communication Retromer Complex Regulation Of Cell Population Proliferation Negative Regulation Of Cell Differentiation Regulation Of Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Extracellular Space Regulation Of Cartilage Development Negative Regulation Of Signaling Negative Regulation Of Cell Communication Signal Transduction Signaling Receptor Binding Regulation Of Multicellular Organismal Process Tissue Morphogenesis Regulation Of Cell Differentiation Morphogenesis Of A Branching Structure Cellular Response To Growth Factor Stimulus Regulation Of Locomotion Tube Morphogenesis Regulation Of Reproductive Process Response To Growth Factor Animal Organ Development Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Cartilage Development Morphogenesis Of An Epithelium Extracellular Region Nodal Signaling Pathway Mesoderm Formation
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