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INHA and SIAH1
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid, two hybrid)
INHA
SIAH1
Description
inhibin subunit alpha
siah E3 ubiquitin protein ligase 1
Image
No pdb structure
GO Annotations
Cellular Component
Photoreceptor Outer Segment
Photoreceptor Inner Segment
Extracellular Region
Extracellular Space
Inhibin-betaglycan-ActRII Complex
Neuronal Cell Body
Inhibin A Complex
Inhibin B Complex
Nucleus
Cytoplasm
Early Endosome
Cytosol
Beta-catenin Destruction Complex
Molecular Function
Signaling Receptor Binding
Cytokine Activity
Hormone Activity
Protein Binding
Growth Factor Activity
Inhibin Binding
Protein-containing Complex Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Ubiquitin Conjugating Enzyme Binding
Identical Protein Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Skeletal System Development
Ovarian Follicle Development
Signal Transduction
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Cell-cell Signaling
Male Gonad Development
Cell Differentiation
Erythrocyte Differentiation
Negative Regulation Of Type II Interferon Production
Regulation Of Cell Population Proliferation
Negative Regulation Of Phosphorylation
Hemoglobin Biosynthetic Process
Negative Regulation Of B Cell Differentiation
Negative Regulation Of Macrophage Differentiation
Negative Regulation Of Cell Cycle
Regulation Of Follicle-stimulating Hormone Secretion
Positive Regulation Of Follicle-stimulating Hormone Secretion
Negative Regulation Of Follicle-stimulating Hormone Secretion
System Development
Negative Regulation Of Multicellular Organismal Process
Regulation Of Cell Cycle
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Spermatogenesis
Nervous System Development
Axon Guidance
Anatomical Structure Morphogenesis
Protein Ubiquitination
Cell Differentiation
Protein Catabolic Process
Protein Destabilization
Positive Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Neuron Apoptotic Process
Canonical Wnt Signaling Pathway
Amyloid Fibril Formation
Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Signaling by Activin
Signaling by Activin
Signaling by BMP
Glycoprotein hormones
TGFBR3 regulates activin signaling
Netrin-1 signaling
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
Premature ovarian failure
GWAS
Femur bone mineral density x serum urate levels interaction (
34046847
)
Height (
28552196
)
Mean corpuscular hemoglobin (
32888494
)
Waist circumference (
28552196
)
Interacting Genes
5 interacting genes:
FST
INHBA
INHBB
SIAH1
TGFBR3
157 interacting genes:
AASDHPPT
AFF1
AFF4
APC
AQP1
ARMC9
ATN1
ATXN7
AXIN1
AXIN2
BAG1
BAG3
BAG4
BCL6
CACYBP
CAPG
CCDC198
CDC23
CDC34
CDK5R1
COPS5
DAB1
DAZAP2
DCC
DDX41
DNAJC15
DNALI1
EEF1D
EIF3J
ELL2
EXOC3-AS1
FAM90A1
FLI1
FZD9
GAPDH
GDPD5
GRM5
H4C16
HCFC1
HIF1AN
HIPK2
HIPK3
INHA
IQCN
ITSN1
KATNAL1
KCNJ10
KHDRBS3
KIAA0319L
KIAA1217
KIF1B
KIF22
KIFC3
KLF10
LACTB2
LANCL2
LMNA
M1AP
MAB21L1
MAP3K5
MAPK12
MAPKBP1
MAPRE3
MOB3C
MTIF3
MX1
NANOS2
NANOS3
NECTIN2
NELFA
NHERF2
NOL6
NTAQ1
NUMB
NUMBL
OPRM1
OTUB2
PARD6B
PCDH17
PEG10
PEG3
PFKM
PHC1
PHC2
PIAS2
PIAS3
PIMREG
PINK1
PKD1
POU2AF1
PRPF31
PRR20B
PRR20C
PRR20D
PRR20E
PTPMT1
PUF60
PYGB
QRICH1
RAB33A
RAB33B
RAD51AP1
RAD54L2
RAPH1
RBBP8
RPL27A
RPS19BP1
RXRB
SDCBP
SFMBT2
SH3RF1
SLAIN1
SNCAIP
SPATA4
SPATC1L
SYP
SYT7
TBC1D22B
TERF2
TFDP1
TMEM43
TNK2
TOLLIP
TP53BP2
TRIM23
TRIM27
TRIM7
TRIM8
TUBA1A
TUBA1B
TUBA3C
TUBA4A
TUBA8
TXN
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E3
UBE2I
UBE2K
UBE2L6
UBE2N
UBE2V2
UPP2
USP19
UXT
VAV1
ZBP1
ZCCHC10
ZCCHC13
ZFYVE21
ZMAT3
ZNF148
ZNF512B
ZNF671
ZYX
Entrez ID
3623
6477
HPRD ID
00933
03736
Ensembl ID
ENSG00000123999
ENSG00000196470
Uniprot IDs
P05111
Q8IUQ4
PDB IDs
2A25
4C9Z
4CA1
4I7B
4I7C
4I7D
4X3G
5WZZ
8HEO
9G0L
Enriched GO Terms of Interacting Partners
?
Cardiac Fibroblast Cell Development
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Response To Gonadotropin
Positive Regulation Of Ovulation
Negative Regulation Of Follicle-stimulating Hormone Secretion
Regulation Of Follicle-stimulating Hormone Secretion
Positive Regulation Of Follicle-stimulating Hormone Secretion
Negative Regulation Of Gonadotropin Secretion
Activin Binding
Gonad Development
Positive Regulation Of Apoptotic Signaling Pathway
Response To Follicle-stimulating Hormone
Cellular Response To Cholesterol
Enzyme-linked Receptor Protein Signaling Pathway
Cellular Response To Sterol
Reproductive Structure Development
Response To Cholesterol
Cell Surface Receptor Signaling Pathway
Response To Ketone
Female Gonad Development
Activin Receptor Signaling Pathway
Developmental Process Involved In Reproduction
Response To Alcohol
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Cell Differentiation
Response To Peptide Hormone
Positive Regulation Of SMAD Protein Signal Transduction
Cardiac Cell Development
Ovarian Follicle Development
Regulation Of Apoptotic Signaling Pathway
Cellular Developmental Process
Negative Regulation Of Hormone Secretion
Regulation Of SMAD Protein Signal Transduction
Regulation Of Signal Transduction
Reproductive Process
Erythrocyte Differentiation
Positive Regulation Of Reproductive Process
Roof Of Mouth Development
Hair Cycle Process
Animal Organ Development
BMP Signaling Pathway
Positive Regulation Of Apoptotic Process
Extracellular Space
Activin A Complex
Anatomical Structure Morphogenesis
Androst-4-ene-3,17-dione Biosynthetic Process
Negative Regulation Of Signaling
Animal Organ Morphogenesis
Negative Regulation Of Cell Communication
Nucleus
Ubiquitin Conjugating Enzyme Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Nucleoplasm
Cytoplasm
Protein Modification By Small Protein Conjugation
Protein Polyubiquitination
Perinuclear Region Of Cytoplasm
Microtubule Cytoskeleton
Post-translational Protein Modification
Identical Protein Binding
Beta-catenin Destruction Complex
Ubiquitin-protein Transferase Activity
Protein K48-linked Ubiquitination
Nuclear Body
Regulation Of JNK Cascade
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleotide Binding
Protein Ubiquitination
Cell Death
Microtubule-based Process
Apoptotic Process
SUMO Transferase Activity
Negative Regulation Of RNA Metabolic Process
Regulation Of RNA Metabolic Process
Programmed Cell Death
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Protein K63-linked Ubiquitination
Regulation Of Primary Metabolic Process
Microtubule Cytoskeleton Organization
Microtubule
Regulation Of Macromolecule Metabolic Process
Microtubule Binding
Organelle Organization
Regulation Of Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Lateral Ventricle Development
Astrocyte Projection
Positive Regulation Of Post-translational Protein Modification
Establishment Of Mitochondrion Localization
UBC13-MMS2 Complex
Neuroblast Division In Subventricular Zone
Modification-dependent Protein Catabolic Process
Regulation Of DNA-templated Transcription
Adenyl-nucleotide Exchange Factor Activity
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
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