INHA and FST

Number of citations of the paper that reports this interaction (PubMedID 2036994)
0

Data Source:
HPRD (in vivo)

		INHA	FST
Description		inhibin subunit alpha	follistatin
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Extracellular Region Extracellular Space Inhibin-betaglycan-ActRII Complex Neuronal Cell Body Inhibin A Complex Inhibin B Complex	Extracellular Region Extracellular Space Nucleus Nucleolus Cytoplasm
	Molecular Function	Signaling Receptor Binding Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Inhibin Binding Protein-containing Complex Binding	Protein Binding Activin Receptor Antagonist Activity Heparan Sulfate Proteoglycan Binding Activin Binding
	Biological Process	Skeletal System Development Ovarian Follicle Development Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Cell-cell Signaling Male Gonad Development Cell Differentiation Erythrocyte Differentiation Negative Regulation Of Type II Interferon Production Regulation Of Cell Population Proliferation Negative Regulation Of Phosphorylation Hemoglobin Biosynthetic Process Negative Regulation Of B Cell Differentiation Negative Regulation Of Macrophage Differentiation Negative Regulation Of Cell Cycle Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Follicle-stimulating Hormone Secretion System Development Negative Regulation Of Multicellular Organismal Process Regulation Of Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Hematopoietic Progenitor Cell Differentiation Gamete Generation Pattern Specification Process Female Gonad Development Cell Differentiation BMP Signaling Pathway Regulation Of BMP Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Hair Follicle Morphogenesis Negative Regulation Of Activin Receptor Signaling Pathway Ameloblast Differentiation Odontogenesis Of Dentin-containing Tooth Keratinocyte Proliferation Positive Regulation Of Hair Follicle Development Cellular Response To Growth Factor Stimulus
Pathways		Signaling by Activin Signaling by Activin Signaling by BMP Glycoprotein hormones TGFBR3 regulates activin signaling	Antagonism of Activin by Follistatin
Drugs			D-Myo-Inositol-Hexasulphate
Diseases		Premature ovarian failure
GWAS			Acne (severe) ( 24927181 30542056) Alzheimer's disease (late onset) ( 30820047) Central corneal thickness ( 32528159) Estimated glomerular filtration rate ( 31152163) HDL cholesterol levels ( 32203549) Height ( 31562340) High-grade serous ovarian cancer ( 31469419) Intraocular pressure ( 29235454 29617998) Keratoconus ( 33649486) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Midgestational circulating levels of PCBs ( 28235828) Optic disc size ( 31809533) Refractive error ( 32231278) Vaginal microbiome composition (community state type) ( 32723796)
Interacting Genes		5 interacting genes: FST INHBA INHBB SIAH1 TGFBR3	14 interacting genes: BEX2 BMP5 C8orf33 CATSPER1 CREB5 FN1 HOXA1 INHA INHBA INHBE MEST TK1 TXN ZNF587
Entrez ID		3623	10468
HPRD ID		00933	00641
Ensembl ID		ENSG00000123999	ENSG00000134363
Uniprot IDs		P05111	P19883
PDB IDs			2B0U 2P6A 3HH2 5JHW
Enriched GO Terms of Interacting Partners?		Cardiac Fibroblast Cell Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Gonadotropin Positive Regulation Of Ovulation Negative Regulation Of Follicle-stimulating Hormone Secretion Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Gonadotropin Secretion Activin Binding Gonad Development Positive Regulation Of Apoptotic Signaling Pathway Response To Follicle-stimulating Hormone Cellular Response To Cholesterol Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Sterol Reproductive Structure Development Response To Cholesterol Cell Surface Receptor Signaling Pathway Response To Ketone Female Gonad Development Activin Receptor Signaling Pathway Developmental Process Involved In Reproduction Response To Alcohol Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Differentiation Response To Peptide Hormone Positive Regulation Of SMAD Protein Signal Transduction Cardiac Cell Development Ovarian Follicle Development Regulation Of Apoptotic Signaling Pathway Cellular Developmental Process Negative Regulation Of Hormone Secretion Regulation Of SMAD Protein Signal Transduction Regulation Of Signal Transduction Reproductive Process Erythrocyte Differentiation Positive Regulation Of Reproductive Process Roof Of Mouth Development Hair Cycle Process Animal Organ Development BMP Signaling Pathway Positive Regulation Of Apoptotic Process Extracellular Space Activin A Complex Anatomical Structure Morphogenesis Androst-4-ene-3,17-dione Biosynthetic Process Negative Regulation Of Signaling Animal Organ Morphogenesis Negative Regulation Of Cell Communication	Inhibin A Complex Negative Regulation Of Follicle-stimulating Hormone Secretion Growth Factor Activity Regulation Of Follicle-stimulating Hormone Secretion Hemoglobin Biosynthetic Process Positive Regulation Of Follicle-stimulating Hormone Secretion Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of B Cell Differentiation Negative Regulation Of Gonadotropin Secretion Negative Regulation Of Macrophage Differentiation Cytokine Activity Hemoglobin Metabolic Process Hormone Activity Regulation Of Macrophage Differentiation Signaling Receptor Binding Activin Receptor Signaling Pathway Negative Regulation Of B Cell Activation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Endodermal Cell Differentiation Regulation Of B Cell Differentiation Reproductive Structure Development Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Leukocyte Activation Negative Regulation Of Type II Interferon Production Negative Regulation Of Immune System Process Negative Regulation Of Cell Activation Semicircular Canal Formation Inhibin B Complex Ovarian Follicle Development Negative Regulation Of Myeloid Leukocyte Differentiation Activin A Complex Androst-4-ene-3,17-dione Biosynthetic Process Negative Regulation Of Lymphocyte Differentiation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of SMAD Protein Signal Transduction Abducens Nerve Formation Optokinetic Behavior Negative Regulation Of Hormone Secretion Erythrocyte Differentiation Cardiac Fibroblast Cell Development Type II Activin Receptor Binding Positive Regulation Of Ovulation Progesterone Secretion Thymidine Kinase Activity Cellular Detoxification Of Hydrogen Peroxide Negative Regulation Of Multicellular Organismal Process Neural Fold Elevation Formation Negative Regulation Of Monocyte Activation Negative Regulation Of Cytokine Production Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate
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