INHA and INHBA

Number of citations of the paper that reports this interaction (PubMedID 11134153)
0

Data Source:
HPRD (in vitro)

		INHA	INHBA
Description		inhibin subunit alpha	inhibin subunit beta A
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Extracellular Region Extracellular Space Inhibin-betaglycan-ActRII Complex Neuronal Cell Body Inhibin A Complex Inhibin B Complex	Extracellular Region Extracellular Space Activin A Complex Inhibin A Complex Perinuclear Region Of Cytoplasm Enzyme Activator Complex
	Molecular Function	Signaling Receptor Binding Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Inhibin Binding Protein-containing Complex Binding	Signaling Receptor Binding Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Peptide Hormone Binding Identical Protein Binding Protein-containing Complex Binding Type II Activin Receptor Binding
	Biological Process	Skeletal System Development Ovarian Follicle Development Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Cell-cell Signaling Male Gonad Development Cell Differentiation Erythrocyte Differentiation Negative Regulation Of Type II Interferon Production Regulation Of Cell Population Proliferation Negative Regulation Of Phosphorylation Hemoglobin Biosynthetic Process Negative Regulation Of B Cell Differentiation Negative Regulation Of Macrophage Differentiation Negative Regulation Of Cell Cycle Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Follicle-stimulating Hormone Secretion System Development Negative Regulation Of Multicellular Organismal Process Regulation Of Cell Cycle	Ovarian Follicle Development Mesoderm Formation Hair Follicle Development Hematopoietic Progenitor Cell Differentiation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Lipid Metabolic Process Steroid Biosynthetic Process Autophagy Defense Response Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Cell-cell Signaling Nervous System Development Steroid Metabolic Process Androgen Metabolic Process Negative Regulation Of Cell Population Proliferation Male Gonad Development Response To Wounding Gene Expression Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Striatal Medium Spiny Neuron Differentiation Cell Differentiation Erythrocyte Differentiation Negative Regulation Of Cell Growth Negative Regulation Of Type II Interferon Production Activin Receptor Signaling Pathway Positive Regulation Of Collagen Biosynthetic Process Endodermal Cell Differentiation Negative Regulation Of Phosphorylation Odontogenesis Hemoglobin Biosynthetic Process Progesterone Secretion Negative Regulation Of B Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Macrophage Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Follicle-stimulating Hormone Secretion Mesodermal Cell Differentiation Cell Development Animal Organ Development System Development Positive Regulation Of Protein Metabolic Process Sertoli Cell Differentiation Roof Of Mouth Development Positive Regulation Of Ovulation Positive Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Cardiac Fibroblast Cell Development Eyelid Development In Camera-type Eye Testosterone Biosynthetic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Cholesterol Cellular Response To Hypoxia Cellular Response To Oxygen-glucose Deprivation GABAergic Neuron Differentiation Extrinsic Apoptotic Signaling Pathway Androst-4-ene-3,17-dione Biosynthetic Process Response To Aldosterone Cellular Response To Angiotensin Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Signaling by Activin Signaling by Activin Signaling by BMP Glycoprotein hormones TGFBR3 regulates activin signaling	Signaling by Activin Signaling by Activin Signaling by BMP Glycoprotein hormones Antagonism of Activin by Follistatin TGFBR3 regulates activin signaling
Drugs			Garetosmab
Diseases		Premature ovarian failure
GWAS			Asthma ( 29273806) Cortisol levels (saliva) ( 28843169) Menarche (age at onset) ( 21102462 25231870 27182965) Parent of origin effect on language impairment (paternal) ( 24571439) Pit-and-Fissure caries ( 23470693)
Interacting Genes		5 interacting genes: FST INHBA INHBB SIAH1 TGFBR3	15 interacting genes: ACVR1 ACVR1B ACVR2A ACVR2B BMPR2 CFTR CHRDL2 ENG FST FSTL3 IGFBP7 INHA INHBB INHBC TGFBR3
Entrez ID		3623	3624
HPRD ID		00933	00929
Ensembl ID		ENSG00000123999	ENSG00000122641
Uniprot IDs		P05111	A4D1W7 P08476
PDB IDs			1NYS 1NYU 1S4Y 2ARP 2ARV 2B0U 2P6A 3B4V 4MID 5HLY 5HLZ 6Y6N 6Y6O 7OLY 7U5P 9I5W
Enriched GO Terms of Interacting Partners?		Cardiac Fibroblast Cell Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Gonadotropin Positive Regulation Of Ovulation Negative Regulation Of Follicle-stimulating Hormone Secretion Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Gonadotropin Secretion Activin Binding Gonad Development Positive Regulation Of Apoptotic Signaling Pathway Response To Follicle-stimulating Hormone Cellular Response To Cholesterol Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Sterol Reproductive Structure Development Response To Cholesterol Cell Surface Receptor Signaling Pathway Response To Ketone Female Gonad Development Activin Receptor Signaling Pathway Developmental Process Involved In Reproduction Response To Alcohol Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Differentiation Response To Peptide Hormone Positive Regulation Of SMAD Protein Signal Transduction Cardiac Cell Development Ovarian Follicle Development Regulation Of Apoptotic Signaling Pathway Cellular Developmental Process Negative Regulation Of Hormone Secretion Regulation Of SMAD Protein Signal Transduction Regulation Of Signal Transduction Reproductive Process Erythrocyte Differentiation Positive Regulation Of Reproductive Process Roof Of Mouth Development Hair Cycle Process Animal Organ Development BMP Signaling Pathway Positive Regulation Of Apoptotic Process Extracellular Space Activin A Complex Anatomical Structure Morphogenesis Androst-4-ene-3,17-dione Biosynthetic Process Negative Regulation Of Signaling Animal Organ Morphogenesis Negative Regulation Of Cell Communication	Activin Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Activin Receptor Signaling Pathway Activin Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity BMP Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Growth Factor Binding Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Complex Regulation Of Cell Communication Regulation Of Signaling Regulation Of Multicellular Organismal Development Positive Regulation Of SMAD Protein Signal Transduction Inhibin-betaglycan-ActRII Complex Activin Receptor Activity, Type II Positive Regulation Of Biomineral Tissue Development Inhibin Binding Activin Receptor Activity BMP Binding Positive Regulation Of Developmental Process Cellular Response To Growth Factor Stimulus Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Signal Transduction Response To Growth Factor Regulation Of Developmental Process Positive Regulation Of Activin Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Receptor Complex Activin Receptor Activity, Type I BMP Receptor Activity Positive Regulation Of Multicellular Organismal Process Cell Surface Positive Regulation Of Bone Mineralization Regulation Of Ossification Regulation Of Multicellular Organismal Process Animal Organ Development Positive Regulation Of Ossification Extracellular Space Coreceptor Activity Regulation Of Cell Differentiation Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Odontogenesis Of Dentin-containing Tooth
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?