IMPDH1 and GMNN

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		IMPDH1	GMNN
Gene Name		IMP (inosine 5-monophosphate) dehydrogenase 1	geminin, DNA replication inhibitor
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cell Junction	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding RNA Binding IMP Dehydrogenase Activity Metal Ion Binding	Transcription Corepressor Activity Protein Binding Histone Deacetylase Binding Repressing Transcription Factor Binding
	Biological Process	Purine Nucleobase Metabolic Process GMP Biosynthetic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Small Molecule Metabolic Process Lymphocyte Proliferation Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process	Mitotic Cell Cycle Protein Complex Assembly Negative Regulation Of DNA Replication Organ Morphogenesis Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated
Pathways		Purine ribonucleoside monophosphate biosynthesis Purine metabolism Metabolism of nucleotides	DNA Replication Pre-Initiation M/G1 Transition Regulation of DNA replication Removal of licensing factors from origins CDT1 association with the CDC6:ORC:origin complex Association of licensing factors with the pre-replicative complex Cell Cycle, Mitotic Assembly of the pre-replicative complex
Drugs		NADH Mycophenolate mofetil Ribavirin Mycophenolic acid 6-Chloropurine Riboside, 5\'-Monophosphate
Diseases
GWAS
Protein-Protein Interactions		2 interactors: GMNN HTRA1	26 interactors: ARNT AURKA CASP3 CCDC146 CDKN1A CDKN2A CDT1 CSNK2A1 HDAC1 HOXA10 HOXA11 HOXA7 HOXB7 HOXC8 HOXC9 HOXD10 IMPDH1 KAT7 MCM6 NCF1 PHC1 REPIN1 SCMH1 SIX3 SMARCA4 ZNF439
Entrez ID		3614	51053
HPRD ID		08853	06783
Ensembl ID		ENSG00000106348	ENSG00000112312
Uniprot IDs		B3KRZ3 E7EQS0 P20839	O75496
PDB IDs		1JCN	1T6F 1UII 2LP0 2WVR 4BRY
Enriched GO Terms of Interacting Partners?		Dentinogenesis Organ Morphogenesis Negative Regulation Of Defense Response To Virus Negative Regulation Of BMP Signaling Pathway Negative Regulation Of DNA Replication Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Defense Response To Virus Regulation Of BMP Signaling Pathway Negative Regulation Of DNA Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Odontogenesis Of Dentin-containing Tooth Regulation Of DNA Replication Anatomical Structure Morphogenesis Odontogenesis	Anterior/posterior Pattern Specification Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Macromolecule Biosynthetic Process Pattern Specification Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Embryonic Morphogenesis Anatomical Structure Morphogenesis Gene Expression Embryonic Organ Development Embryonic Organ Morphogenesis Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Embryo Development Proximal/distal Pattern Formation Embryonic Skeletal System Morphogenesis Regulation Of Cell Cycle Multicellular Organismal Development Negative Regulation Of Cell Cycle Developmental Process Skeletal System Morphogenesis Organ Morphogenesis Regulation Of Cell Cycle Process Embryonic Limb Morphogenesis Embryonic Skeletal System Development Regulation Of Metabolic Process Limb Morphogenesis Skeletal System Development Metabolic Process Chromatin Modification Limb Development Organ Development System Development Anatomical Structure Development Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Phase Transition Positive Regulation Of Transcription, DNA-templated
Tagcloud ?		abcc4 abcc5 all97 atp6ap2 caucasian childhood cytotoxicity frmd4b genotyped gng2 itpa kcnma1 lymphoblastic lymphoblastoid mercaptopurine nme1 outside shifts slc28a3 snp snps tagsnps thioguanine thiopurine thiopurines top uk validation xdh
Tagcloud (Difference) ?		abcc4 abcc5 all97 atp6ap2 caucasian childhood cytotoxicity frmd4b genotyped gng2 itpa kcnma1 lymphoblastic lymphoblastoid mercaptopurine nme1 outside shifts slc28a3 snp snps tagsnps thioguanine thiopurine thiopurines top uk validation xdh
Tagcloud (Intersection) ?