IMPDH1 and RAD54L2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IMPDH1	RAD54L2
Description		inosine monophosphate dehydrogenase 1	RAD54 like 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Secretory Granule Lumen Azurophil Granule Lumen Ficolin-1-rich Granule Lumen	Nucleus Nuclear Body
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding RNA Binding Catalytic Activity IMP Dehydrogenase Activity Protein Binding Oxidoreductase Activity Identical Protein Binding Metal Ion Binding	Nucleotide Binding DNA Binding Transcription Coregulator Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity ATP-dependent Chromatin Remodeler Activity
	Biological Process	Purine Nucleotide Biosynthetic Process GMP Biosynthetic Process GTP Biosynthetic Process Lymphocyte Proliferation 'de Novo' XMP Biosynthetic Process	Chromatin Organization Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Neutrophil degranulation Purine ribonucleoside monophosphate biosynthesis Potential therapeutics for SARS Azathioprine ADME
Drugs		NADH Mycophenolate mofetil Ribavirin Mycophenolic acid Mercaptopurine 6-Chloropurine Riboside, 5'-Monophosphate VX-148 Taribavirin
Diseases		Leber congenital amaurosis (LCR) Retinitis pigmentosa (RP)
GWAS		Pelvic organ prolapse ( 32184442)	Estimated glomerular filtration rate ( 31152163)
Interacting Genes		8 interacting genes: DDIT4L GMNN HTRA1 OGT PIAS2 RAD54L2 RNF4 UBE2I	44 interacting genes: AR ATN1 ATXN1 ATXN1L BANP BHLHE40 CBX3 CRK FAM118B FXR2 HMG20A HNRNPCL1 HOMER1 IMPDH1 KIFC3 KRTAP6-3 LCE1D LCE1F NR3C1 NR5A1 NR5A2 PAICS PIAS1 POU1F1 PPARG PSMA3 RAD51 RBPMS RUNX1T1 RXRA SIAH1 SQSTM1 SUMO1 SUMO2 SUMO3 TAX1BP1 TFAP2D THAP1 TRAF2 TRAF4 UBE2I VCX ZBTB26 ZC2HC1A
Entrez ID		3614	23132
HPRD ID		08853	10018
Ensembl ID		ENSG00000106348	ENSG00000164080
Uniprot IDs		P20839	B3KV54 Q9Y4B4
PDB IDs		1JCN 7RER 7RES 7RFE 7RFF 7RFG 7RFH 7RFI 7RGD 7RGI 7RGL 7RGM 7RGQ 8U7M 8U7Q 8U7V 8U8O 8U8Y
Enriched GO Terms of Interacting Partners?		PML Body SUMO Transferase Activity Chorionic Trophoblast Cell Differentiation Negative Regulation Of Signal Transduction Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Proteolysis Regulation Of Kinetochore Assembly Regulation Of Centromere Complex Assembly Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Nuclear Body Regulation Of RNA Metabolic Process SUMO Polymer Binding Regulation Of RNA Biosynthetic Process Negative Regulation Of Protein Localization To Chromatin Microtubule End Regulation Of Transcription By RNA Polymerase II RING-like Zinc Finger Domain Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription SUMO Ligase Complex Protein Sumoylation Small Protein Activating Enzyme Binding HLH Domain Binding Negative Regulation Of RNA Biosynthetic Process SUMO Conjugating Enzyme Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein N-acetylglucosaminyltransferase Complex Non-canonical Inflammasome Complex Assembly Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Transcription Coregulator Activity DNA Replication Preinitiation Complex Assembly Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Modification By Small Protein Conjugation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Carbon Catabolite Regulation Of Transcription Positive Regulation Of Chromatin Binding Transcription Corepressor Activity Protein Modification Process Regulation Of Protein Localization To Chromatin Regulation Of Transcription By Glucose Mitotic Nuclear Membrane Reassembly Protein Metabolic Process Transferase Activity	Identical Protein Binding Enzyme Binding PML Body Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Transcription Coregulator Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor Activity Nucleus Postsynaptic Cytosol Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Protein Sumoylation Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Transcription By RNA Polymerase II 'de Novo' XMP Biosynthetic Process Presynaptic Cytosol Ubiquitin Protein Ligase Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Intracellular Receptor Signaling Pathway Signaling Adaptor Activity Hormone-mediated Signaling Pathway Chromatin Regulation Of Primary Metabolic Process Chromatin Binding GMP Biosynthetic Process IMP Dehydrogenase Activity DNA-binding Transcription Factor Activity Negative Regulation Of Metabolic Process Protein Tag Activity Purine Ribonucleoside Monophosphate Biosynthetic Process Zinc Ion Binding Regulation Of Gene Expression SUMO Transferase Activity Sequence-specific DNA Binding Double-stranded DNA Binding RNA Polymerase II Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process
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