IMPDH1

Description		inosine monophosphate dehydrogenase 1
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GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Secretory Granule Lumen Azurophil Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding RNA Binding Catalytic Activity IMP Dehydrogenase Activity Protein Binding Oxidoreductase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Purine Nucleotide Biosynthetic Process GMP Biosynthetic Process GTP Biosynthetic Process Lymphocyte Proliferation 'de Novo' XMP Biosynthetic Process
Pathways		Neutrophil degranulation Purine ribonucleoside monophosphate biosynthesis Potential therapeutics for SARS Azathioprine ADME
Drugs		NADH Mycophenolate mofetil Ribavirin Mycophenolic acid Mercaptopurine 6-Chloropurine Riboside, 5'-Monophosphate VX-148 Taribavirin
Diseases		Leber congenital amaurosis (LCR) Retinitis pigmentosa (RP)
GWAS		Pelvic organ prolapse ( 32184442)
Interacting Genes		8 interacting genes: DDIT4L GMNN HTRA1 OGT PIAS2 RAD54L2 RNF4 UBE2I
Entrez ID		3614
HPRD ID		08853
Ensembl ID		ENSG00000106348
Uniprot IDs		P20839
PDB IDs		1JCN 7RER 7RES 7RFE 7RFF 7RFG 7RFH 7RFI 7RGD 7RGI 7RGL 7RGM 7RGQ 8U7M 8U7Q 8U7V 8U8O 8U8Y
Enriched GO Terms of Interacting Partners?		PML Body SUMO Transferase Activity Chorionic Trophoblast Cell Differentiation Negative Regulation Of Signal Transduction Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Proteolysis Regulation Of Kinetochore Assembly Regulation Of Centromere Complex Assembly Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Nuclear Body Regulation Of RNA Metabolic Process SUMO Polymer Binding Regulation Of RNA Biosynthetic Process Negative Regulation Of Protein Localization To Chromatin Microtubule End Regulation Of Transcription By RNA Polymerase II RING-like Zinc Finger Domain Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription SUMO Ligase Complex Protein Sumoylation Small Protein Activating Enzyme Binding HLH Domain Binding Negative Regulation Of RNA Biosynthetic Process SUMO Conjugating Enzyme Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein N-acetylglucosaminyltransferase Complex Non-canonical Inflammasome Complex Assembly Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Transcription Coregulator Activity DNA Replication Preinitiation Complex Assembly Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Modification By Small Protein Conjugation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Carbon Catabolite Regulation Of Transcription Positive Regulation Of Chromatin Binding Transcription Corepressor Activity Protein Modification Process Regulation Of Protein Localization To Chromatin Regulation Of Transcription By Glucose Mitotic Nuclear Membrane Reassembly Protein Metabolic Process Transferase Activity
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