IMPA2 and TNFRSF14

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		IMPA2	TNFRSF14
Gene Name		inositol(myo)-1(or 4)-monophosphatase 2	tumor necrosis factor receptor superfamily, member 14
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Inositol Monophosphate 1-phosphatase Activity Protein Homodimerization Activity Metal Ion Binding Inositol Monophosphate 3-phosphatase Activity Inositol Monophosphate 4-phosphatase Activity	Virus Receptor Activity Tumor Necrosis Factor-activated Receptor Activity Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Inositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Signal Transduction Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation Inositol Phosphate Dephosphorylation	Positive Regulation Of Cytokine Secretion Involved In Immune Response Immune Response Cell Surface Receptor Signaling Pathway Response To Virus Viral Process T Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of T Cell Migration
Pathways		Synthesis of IP2, IP, and Ins in the cytosol Inositol phosphate metabolism	Costimulation by the CD28 family Adaptive Immune System
Drugs		Lithium
Diseases
GWAS		Stroke ( 17434096)	Celiac disease ( 20190752) Rheumatoid arthritis ( 18794853 20453842) Ulcerative colitis ( 23128233 21297633)
Protein-Protein Interactions		4 interactors: HERPUD1 IMPA1 TNFRSF14 UBA3	30 interactors: A2M APP BTLA CD160 CHD3 DGKD DRAP1 DYNLL1 ESR1 HDAC3 HDAC4 IMPA2 ITFG1 KIAA1377 LTA MBTPS1 NDUFS2 NRIP1 RAD21 SERPINA4 TNFSF13 TNFSF14 TRAF1 TRAF2 TRAF3 TRAF5 UBQLN4 VIM WDR73 ZBTB48
Entrez ID		3613	8764
HPRD ID		09329	04122
Ensembl ID		ENSG00000141401	ENSG00000157873
Uniprot IDs		O14732	Q92956
PDB IDs		2CZH 2CZI 2CZK 2DDK 2FVZ	1JMA 2AW2 4FHQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Endomitotic Cell Cycle Positive Regulation Of Cytokine Secretion Involved In Immune Response	Signal Transduction Apoptotic Process Programmed Cell Death Signaling Cell Communication Cell Death Death Cellular Response To Stimulus Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cellular Process Response To Stimulus Regulation Of Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Proteolysis Regulation Of Nitrogen Compound Metabolic Process Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Immune Response Regulation Of Endopeptidase Activity Regulation Of Immune System Process Regulation Of Peptidase Activity Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Protein Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription Factor Import Into Nucleus Response To Stress Negative Regulation Of Endopeptidase Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Peptidase Activity Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cell Activation Histone H4 Deacetylation Positive Regulation Of NF-kappaB Transcription Factor Activity Spindle Organization Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Immune System Process Immune System Process Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Protein Binding Negative Regulation Of Proteolysis Positive Regulation Of Adaptive Immune Response Positive Regulation Of Immunoglobulin Mediated Immune Response Histone H3 Deacetylation Negative Regulation Of Protein Processing Regulation Of Transcription From RNA Polymerase II Promoter Histone H3-K9 Modification Regulation Of Establishment Of Protein Localization
Tagcloud ?		accomplices counterbalance dao daoa dictate dpysl2 dtnbp1 famine grin1 grin2b grm3 grm4 hypomyelination il1b il1rn metabotropic ncam1 nd4 ndufv2 nos1 nos1ap nurture oligodendrocyte pdlim5 pik3c3 pip5k2a reconcile rgs4 ywhah	aberrations additional advances approaches biological closely contribute crebbp ep300 epha7 expected ezh2 fl follicular genetic hallmark hand individuals lymphoma mef2b microenvironment mll2 pathogenesis recognized recurrent technology translocation understanding unique
Tagcloud (Difference) ?		accomplices counterbalance dao daoa dictate dpysl2 dtnbp1 famine grin1 grin2b grm3 grm4 hypomyelination il1b il1rn metabotropic ncam1 nd4 ndufv2 nos1 nos1ap nurture oligodendrocyte pdlim5 pik3c3 pip5k2a reconcile rgs4 ywhah	aberrations additional advances approaches biological closely contribute crebbp ep300 epha7 expected ezh2 fl follicular genetic hallmark hand individuals lymphoma mef2b microenvironment mll2 pathogenesis recognized recurrent technology translocation understanding unique
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