IMPA2 and HERPUD1

Number of citations: 0 (PubMedID 16169070)
Data Source: HPRD (two hybrid)

		IMPA2	HERPUD1
Name		inositol monophosphatase 2	homocysteine inducible ER protein with ubiquitin like domain 1
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Hrd1p Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Quality Control Compartment Lewy Body Core
	Molecular Function	Protein Binding Glucose-1-phosphatase Activity Inositol Monophosphate 1-phosphatase Activity Hydrolase Activity Protein Homodimerization Activity Metal Ion Binding Glycerol-2-phosphatase Activity Inositol Monophosphate 3-phosphatase Activity Inositol Monophosphate 4-phosphatase Activity Inositol Monophosphate Phosphatase Activity	Protein Binding Transmembrane Transporter Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Inositol Metabolic Process Inositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Signal Transduction Response To Lithium Ion Phosphatidylinositol Phosphate Biosynthetic Process	Ubiquitin-dependent Protein Catabolic Process Intracellular Calcium Ion Homeostasis Response To Unfolded Protein Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Regulation Of Protein Ubiquitination Endoplasmic Reticulum Calcium Ion Homeostasis Response To Endoplasmic Reticulum Stress ERAD Pathway Protein Targeting To ER Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of ERAD Pathway Positive Regulation Of ERAD Pathway Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Synthesis of IP2, IP, and Ins in the cytosol	ATF4 activates genes in response to endoplasmic reticulum stress
Drugs		Lithium cation Lithium citrate Lithium succinate Lithium carbonate	None
GWAS		Diabetic peripheral neuropathy in type 2 diabetes ( 31127053 ) Hemoglobin ( 32888494 ) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744 ) Stroke ( 17434096 )	Aspartate aminotransferase levels ( 33547301 ) Cardiovascular risk factors ( 20838585 ) Coronary artery disease ( 29212778 ) Diisocyanate-induced asthma ( 25918132 ) HDL cholesterol ( 20031564 23505323 24886709 ) HDL Cholesterol in HIV-infection ( 25884002 ) HDL cholesterol levels ( 26763881 30698716 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels in HIV infection ( 33109212 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) High density lipoprotein cholesterol levels ( 29403010 33339817 ) Hip circumference adjusted for BMI ( 34021172 ) Hypo-HDL-cholesterolemia ( 31087446 ) LDL cholesterol levels ( 30698716 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Low density lipoprotein cholesterol levels ( 33339817 ) Low HDL-cholesterol levels ( 31910446 ) Metabolic syndrome ( 20694148 ) Metabolite levels ( 23823483 ) Serum metabolite levels ( 33031748 ) Total cholesterol levels ( 29403010 33339817 ) Triglyceride levels ( 29403010 33339817 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 )
Interacting Genes		5 interacting genes: CCT6A HERPUD1 SLC44A3 TNFRSF14 UBA3	19 interacting genes: AMFR APP ARHGDIA C5AR2 CCR2 CD3D CD58 CHRM2 EWSR1 F2RL1 IMPA2 PSEN1 RPA2 SH3RF1 STARD9 TOLLIP UBQLN2 USP7 XRCC6
Entrez ID		3613	9709
HPRD ID		09329	07456
Ensembl ID		ENSG00000141401	ENSG00000051108
Uniprot IDs		O14732	A4UAE9 Q15011 Q53FP9
PDB IDs		2CZH 2CZI 2CZK 2DDK 2FVZ	1WGD
GO Terms Enriched among Interactors		Positive Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Adaptive Immune Memory Response Endomitotic Cell Cycle NEDD8 Activating Enzyme Activity Lewy Body Core	Regulation Of Vesicle-mediated Transport Signal Transduction Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Astrocyte Activation Involved In Immune Response Regulation Of Immune Response Regulation Of Tumor Necrosis Factor Production Regulation Of Proteolysis Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Immune System Process Regulation Of Chemotaxis Positive Regulation Of Protein Catabolic Process Positive Regulation Of Type II Interferon Production Immune System Process Positive Regulation Of Immune Response Regulation Of Proteasomal Protein Catabolic Process Neuron Projection Maintenance Regulation Of Leukocyte Migration Dendrite Protein-containing Complex Regulation Of Synaptic Vesicle Cycle Regulation Of Interleukin-8 Production Response To Stress Regulation Of Immune System Process Positive Regulation Of Leukocyte Chemotaxis Autophagosome Assembly Immune Response Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cytokine Production Regulation Of Amyloid Fibril Formation Positive Regulation Of JNK Cascade Astrocyte Activation Regulation Of Cytokine Production Autophagosome Organization Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Superoxide Anion Generation Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Catabolic Process Regulation Of Type II Interferon Production Positive Regulation Of Monocyte Chemotaxis Leukocyte Activation Positive Regulation Of Glycolytic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Intracellular Signal Transduction Myeloid Leukocyte Activation Early Endosome