TNFRSF14 and UNC93A

		TNFRSF14	UNC93A
Description		TNF receptor superfamily member 14	unc-93 homolog A
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Plasma Membrane Membrane
	Molecular Function	Virus Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding Cytokine Binding Ubiquitin Protein Ligase Binding Receptor Ligand Activity	Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process Positive Regulation Of Cytokine Production Involved In Immune Response Immune Response Cell Surface Receptor Signaling Pathway T Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of T Cell Proliferation Innate Immune Response Negative Regulation Of Alpha-beta T Cell Proliferation Symbiont Entry Into Host Cell Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Negative Regulation Of Adaptive Immune Memory Response Positive Regulation Of T Cell Migration
Pathways		TNFs bind their physiological receptors Co-inhibition by BTLA Co-inhibition by BTLA
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Autoimmune thyroid disease ( 32581359) Body mass index ( 26426971) Celiac disease ( 20190752) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 28067908) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 28445677) Primary sclerosing cholangitis ( 23603763) Rheumatoid arthritis ( 24390342 24449572 18794853 30423114) Ulcerative colitis ( 26398853 28067908 23128233 21297633)	Initial alcohol sensitivity ( 30276832) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		30 interacting genes: A2M APP BTLA CD160 CEP126 CHD3 DGKD DRAP1 DYNLL1 ESR1 HDAC3 HDAC4 IMPA2 ITFG1 LTA MBTPS1 NDUFS2 NRIP1 RAD21 SERPINA4 TNFSF13 TNFSF14 TRAF1 TRAF2 TRAF3 TRAF5 UBQLN4 VIM WDR73 ZBTB48	22 interacting genes: ABHD16A AQP6 ATP13A1 CCL4 CD300C CDIPT FCER1G FXYD6-FXYD2 GJA8 GPR101 GPR151 LNPEP PSCA RHAG SLC35E4 SLC39A7 SLC48A1 SYNGR1 TIMMDC1 TMEM14B TMEM237 TMX2
Entrez ID		8764	54346
HPRD ID		04122	12148
Ensembl ID		ENSG00000157873	ENSG00000112494
Uniprot IDs		B9A034 Q92956	Q86WB7
PDB IDs		1JMA 2AW2 4FHQ 4RSU 5T2Q 5T2R 6NG3 7MSG
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding Thioesterase Binding Identical Protein Binding CD40 Receptor Complex Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Signaling Receptor Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Biosynthetic Process Signaling Adaptor Activity Regulation Of Immune Response Regulation Of Apoptotic Process Regulation Of DNA-binding Transcription Factor Activity Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Tumor Necrosis Factor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Histone Deacetylase Complex Apoptotic Process Nitric-oxide Synthase Regulator Activity Programmed Cell Death Cell Death Transcription Corepressor Binding Positive Regulation Of Lymphocyte Mediated Immunity Negative Regulation Of Glial Cell Apoptotic Process CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Deacetylase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Apoptotic Signaling Pathway Enzyme Binding Positive Regulation Of Gene Expression Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Protein Deacetylation Protein Lysine Deacetylase Activity Regulation Of Nitric Oxide Metabolic Process Regulation Of Immune System Process Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Type II Interferon Production Immune System Process Regulation Of ATP Metabolic Process Chromatin Binding Positive Regulation Of Metabolic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity	Membrane Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Ammonium Transmembrane Transport Ammonium Channel Activity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Carbon Dioxide Transport Transmembrane Transport One-carbon Compound Transport Nitrate Transmembrane Transporter Activity Inorganic Cation Transmembrane Transport Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I IgE Receptor Activity Antigen Processing And Presentation Of Exogenous Peptide Antigen Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Methylammonium Transmembrane Transporter Activity CDP-diacylglycerol-inositol 3-phosphatidyltransferase Activity Heme Export From Vacuole To Cytoplasm Heme Metabolic Process Extraction Of Mislocalized Protein From ER Membrane ABC-type Manganese Transporter Activity Membrane Protein Dislocase Activity Positive Regulation Of Lymphocyte Migration Porphyrin-containing Compound Metabolic Process PH-gated Chloride Channel Activity Inorganic Ion Transmembrane Transport Nitrate Transmembrane Transport Antigen Processing And Presentation Of Exogenous Antigen Positive Regulation Of Type I Hypersensitivity Plasma Membrane Fc-epsilon Receptor I Complex Methylammonium Transport Methylammonium Transmembrane Transport Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Negative Regulation Of Adaptive Immune Memory Response Alcohol Binding Mitochondrial Membrane Pigment Metabolic Process Tetrapyrrole Metabolic Process Heme Export
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