TNFRSF14 and TNFSF13

Number of citations: 0 (PubMedID 10706119)
Data Source: BioGRID (pull down), HPRD (in vitro)

		TNFRSF14	TNFSF13
Name		TNF receptor superfamily member 14	TNF superfamily member 13
Structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Cytosol Membrane Extracellular Exosome
	Molecular Function	Virus Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding Cytokine Binding Ubiquitin Protein Ligase Binding Receptor Ligand Activity	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process Positive Regulation Of Cytokine Production Involved In Immune Response Immune Response Cell Surface Receptor Signaling Pathway T Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of T Cell Proliferation Innate Immune Response Negative Regulation Of Alpha-beta T Cell Proliferation Symbiont Entry Into Host Cell Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Negative Regulation Of Adaptive Immune Memory Response Positive Regulation Of T Cell Migration	Lymphocyte Homeostasis Immune System Process Immune Response Cell Communication Signal Transduction Positive Regulation Of Cell Population Proliferation Signaling Positive Regulation Of B Cell Proliferation Positive Regulation Of Isotype Switching To IgA Isotypes
Pathways		TNFs bind their physiological receptors Co-inhibition by BTLA Co-inhibition by BTLA	HuR (ELAVL1) binds and stabilizes mRNA TNFs bind their physiological receptors
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Autoimmune thyroid disease ( 32581359 ) Body mass index ( 26426971 ) Celiac disease ( 20190752 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Inflammatory bowel disease ( 28067908 ) Medication use (thyroid preparations) ( 31015401 ) Multiple sclerosis ( 28445677 ) Primary sclerosing cholangitis ( 23603763 ) Rheumatoid arthritis ( 24390342 24449572 18794853 30423114 ) Ulcerative colitis ( 26398853 28067908 23128233 21297633 )	Albumin-globulin ratio ( 29403010 ) Bitter alcoholic beverage consumption ( 31046077 ) Brain morphology (MOSTest) ( 32665545 ) Chin dimples ( 27182965 ) Composite immunoglobulin trait (IgA x IgG x IgM) ( 28628107 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) IgA levels ( 28628107 22864923 ) IgA nephropathy ( 22197929 26028593 25305756 ) IgM levels ( 23118916 ) Myopia ( 27182965 ) Non-albumin protein levels ( 29403010 22558069 ) Serum total protein levels ( 29403010 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 )
Interacting Genes		30 interacting genes: A2M APP BTLA CD160 CEP126 CHD3 DGKD DRAP1 DYNLL1 ESR1 HDAC3 HDAC4 IMPA2 ITFG1 LTA MBTPS1 NDUFS2 NRIP1 RAD21 SERPINA4 TNFSF13 TNFSF14 TRAF1 TRAF2 TRAF3 TRAF5 UBQLN4 VIM WDR73 ZBTB48	13 interacting genes: CAMK1D FAS FURIN KRAS PIK3CA SDC2 SGTB TNFRSF11B TNFRSF13B TNFRSF14 TNFRSF17 TNFRSF1A TNFSF13B
Entrez ID		8764	8741
HPRD ID		04122	05128
Ensembl ID		ENSG00000157873	ENSG00000161955
Uniprot IDs		B9A034 Q92956	O75888 Q2QBA2
PDB IDs		1JMA 2AW2 4FHQ 4RSU 5T2Q 5T2R 6NG3 7MSG	4ZCH
GO Terms Enriched among Interactors		Tumor Necrosis Factor Receptor Binding Thioesterase Binding Identical Protein Binding CD40 Receptor Complex Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Signaling Receptor Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Biosynthetic Process Signaling Adaptor Activity Regulation Of Immune Response Regulation Of Apoptotic Process Regulation Of DNA-binding Transcription Factor Activity Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Tumor Necrosis Factor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Histone Deacetylase Complex Apoptotic Process Nitric-oxide Synthase Regulator Activity Programmed Cell Death Cell Death Transcription Corepressor Binding Positive Regulation Of Lymphocyte Mediated Immunity Negative Regulation Of Glial Cell Apoptotic Process CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Deacetylase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Apoptotic Signaling Pathway Enzyme Binding Positive Regulation Of Gene Expression Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Protein Deacetylation Protein Lysine Deacetylase Activity Regulation Of Nitric Oxide Metabolic Process Regulation Of Immune System Process Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Type II Interferon Production Immune System Process Regulation Of ATP Metabolic Process Chromatin Binding Positive Regulation Of Metabolic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity	Tumor Necrosis Factor-mediated Signaling Pathway Tumor Necrosis Factor Receptor Activity Cytokine-mediated Signaling Pathway Signaling Receptor Activity Cell Surface Receptor Signaling Pathway Signal Transduction Homeostasis Of Number Of Cells Lymphocyte Homeostasis Heparan Sulfate Binding Plasma Membrane Multicellular Organismal-level Homeostasis Leukocyte Homeostasis Adaptive Immune Response Regulation Of Immune System Process B Cell Homeostasis Response To Mechanical Stimulus Cell Death Membrane Raft Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apoptotic Process Programmed Cell Death Regulation Of Multicellular Organismal Process Negative Regulation Of Immune System Process T Cell Costimulation Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Regulation Of Mononuclear Cell Proliferation Regulation Of Developmental Process Immune Response Cellular Response To Mechanical Stimulus Immune System Process Cell Surface Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Multicellular Organismal Process Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Negative Regulation Of Adaptive Immune Memory Response Regulation Of Leukocyte Proliferation Positive Regulation Of Germinal Center Formation Regulation Of B Cell Proliferation Transitional One Stage B Cell Differentiation TRC Complex Homeostatic Process Fas Signaling Pathway GMP Binding