IMPA2 and CCT6A

Number of citations: 48 (PubMedID 23414517)
Data Source: BioGRID (two hybrid)

		IMPA2	CCT6A
Name		inositol monophosphatase 2	chaperonin containing TCP1 subunit 6A
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Cytosol Chaperonin-containing T-complex Microtubule Extracellular Exosome
	Molecular Function	Protein Binding Glucose-1-phosphatase Activity Inositol Monophosphate 1-phosphatase Activity Hydrolase Activity Protein Homodimerization Activity Metal Ion Binding Glycerol-2-phosphatase Activity Inositol Monophosphate 3-phosphatase Activity Inositol Monophosphate 4-phosphatase Activity Inositol Monophosphate Phosphatase Activity	Nucleotide Binding RNA Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein Folding Chaperone Unfolded Protein Binding WD40-repeat Domain Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Inositol Metabolic Process Inositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Signal Transduction Response To Lithium Ion Phosphatidylinositol Phosphate Biosynthetic Process	Protein Folding Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		Synthesis of IP2, IP, and Ins in the cytosol	Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding RHOBTB2 GTPase cycle
Drugs		Lithium cation Lithium citrate Lithium succinate Lithium carbonate	None
GWAS		Diabetic peripheral neuropathy in type 2 diabetes ( 31127053 ) Hemoglobin ( 32888494 ) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744 ) Stroke ( 17434096 )	Coronary artery disease ( 33020668 ) Estimated glomerular filtration rate ( 31015462 ) Hip circumference adjusted for BMI ( 34021172 ) Macular telangiectasia type 2 ( 33654266 ) Plasma free amino acid levels ( 30659259 ) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259 ) Systolic blood pressure ( 30224653 )
Interacting Genes		5 interacting genes: CCT6A HERPUD1 SLC44A3 TNFRSF14 UBA3	17 interacting genes: CEBPA DUX4 ERCC6 IMPA2 KDM5A LINC01554 MLX MYBPC2 OGT PARP4 PTEN SGCG SUMO2 SUMO4 SUPT16H TRIM31 TTN
Entrez ID		3613	908
HPRD ID		09329	00089
Ensembl ID		ENSG00000141401	ENSG00000146731
Uniprot IDs		O14732	P40227
PDB IDs		2CZH 2CZI 2CZK 2DDK 2FVZ	6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8 7LUM 7LUP 7NVL 7NVM 7NVN 7NVO 7TRG 7TTN 7TTT 7TUB 7WU7 7WZ3 7X0A 7X0S 7X0V 7X3J 7X3U 7X6Q 7X7Y 8HKI 8I1U 8I9U 8IB8 8SFE 8SFF 8SG8 8SG9 8SGC 8SGL 8SGQ 8SH9 8SHA 8SHD 8SHE 8SHF 8SHG 8SHL 8SHN 8SHO 8SHP 8SHQ 8SHT
GO Terms Enriched among Interactors		Positive Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Adaptive Immune Memory Response Endomitotic Cell Cycle NEDD8 Activating Enzyme Activity Lewy Body Core	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Proteolysis Positive Regulation Of Metabolic Process Chromatin DNA Binding Regulation Of RNA Metabolic Process Protein Tag Activity Positive Regulation Of Transcription By RNA Polymerase II Response To Lithium Ion Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Elongation Factor Complex Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Gene Expression M Band Circadian Rhythm Ubiquitin-like Protein Ligase Binding Negative Regulation Of Cell Cycle Regulation Of Peptidyl-serine Phosphorylation Regulation Of Proteolysis Protein Modification Process Sarcomere Organization Structural Constituent Of Muscle Positive Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Synaptic Vesicle Clustering Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Macromolecule Metabolic Process Protein Sumoylation Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Elongation Nucleoplasm Inflammatory Response Response To Vitamin B2 C/EBP Complex Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Glycerol-2-phosphatase Activity